The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Label-free biomarker detection from whole blood
Open accessAbstract
Label-free nanosensors can detect disease markers to provide point-of-care diagnosis that is low-cost, rapid, specific and sensitive. However, detecting these biomarkers in physiological fluid samples is difficult because of ionic screening. Here, we overcome this limitation by using distinct components within the sensor to perform purification and detection.1 A microfluidic purification chip captures multiple biomarkers simultaneously from blood samples and releases them, after washing, into purified buffer for sensing by a silicon nanoribbon detector. This two-stage approach isolates the detector from the complex environment of whole blood, and reduces its minimum required sensitivity by effectively pre-concentrating the biomarkers. We show specific and quantitative detection of two model cancer antigens from a 10 uL sample of whole blood in less than 20 minutes.
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Citations
Cites
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Self-citationWeighing of biomolecules, single cells and single nanoparticles in fluid
Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature · doi:10.1038/nature05741 · Cited by 1,213
Importance of the Debye Screening Length on Nanowire Field Effect Transistor Sensors
Stern, E., Wagner, R., Sigworth, F. J., Breaker, R., Fahmy, T. M., & Reed, M. A. (2007) · Nano Letters · doi:10.1021/nl071792z · Cited by 806
Self-citation
Cited by
MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors
Sarkar, D., Liu, W., Xie, X., Anselmo, A. C., Mitragotri, S., & Banerjee, K. (2014) · ACS Nano · doi:10.1021/nn5009148 · Cited by 1,047
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873
Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials
Meng, Z., Stolz, R. M., Mendecki, L., & Mirica, K. A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00311 · Cited by 773
Biosensors based on nanomechanical systems
Tamayo, J., Kosaka, P. M., Ruz, J. J., San Paulo, Á., & Calleja, M. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35293a · Cited by 391
Micro Total Analysis Systems for Cell Biology and Biochemical Assays
Kovarik, M. L., Gach, P. C., Ornoff, D. M., Wang, Y., Balowski, J., Farrag, L., & Allbritton, N. L. (2012) · Analytical Chemistry · doi:10.1021/ac202611x · Cited by 270
Metadata
- Authors
- Stern, E., Vacic, A., Rajan, N. K., Criscione, J. M., Park, J., Ilic, B. R., Mooney, D. J., Reed, M. A., & Fahmy, T. M.
- Venue
- Nature Nanotechnology
- Published
- 2009-12-13
- Volume
- 5
- Issue
- 2
- Pages
- 138-142
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2023834245
- Cited by
- 543
- References
- 3
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Stern, E., Vacic, A., Rajan, N. K., Criscione, J. M., Park, J., Ilic, B. R., Mooney, D. J., Reed, M. A., & Fahmy, T. M. (2010). Label-free biomarker detection from whole blood. Nature Nanotechnology. https://doi.org/10.1038/nnano.2009.353
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