Importance of the Debye Screening Length on Nanowire Field Effect Transistor Sensors
Open accessAbstract
Nanowire field effect transistors (NW-FETs) can serve as ultrasensitive detectors for label-free reagents. The NW-FET sensing mechanism assumes a controlled modification in the local channel electric field created by the binding of charged molecules to the nanowire surface. Careful control of the solution Debye length is critical for unambiguous selective detection of macromolecules. Here we show the appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors.
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The potential distribution of the channel surface determines the electron concentration of the transistor and is closely correlated to the amount of drain current inside the biosensor.
“The potential distribution of the channel surface determines the electron concentration of the transistor and is closely correlated to the amount of drain current inside the biosensor [37].”
From A Vertically Stacked Nanosheet Gate-All-Around FET for Biosensing Application (2021) · cites this paper as [37]
The immune-sensor has an inherent impediment in determining bio-molecules that is induced by the Debye screening length.
“Among them, the immune-sensor has an inherent impediment in determining bio-molecules that is induced by the Debye screening length910, despite the current need of femtomolar detection for early-stage diagnosis of diseases.”
From Performance Enhancement of Capacitive-Coupling Dual-gate Ion-Sensitive Field-Effect Transistor in Ultra-Thin-Body (2014) · cites this paper as [9]
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- Authors
- Stern, E., Wagner, R., Sigworth, F. J., Breaker, R., Fahmy, T. M., & Reed, M. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fahmy, Tarek M.
- Reed, Mark A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-10-03
- Volume
- 7
- Issue
- 11
- Pages
- 3405-3409
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- PMC
- PMC2713684
- OpenAlex
- W1968221386
- Cited by
- 806
- References
- 0
- Citations by year
- 2026: 40 · 2025: 40 · 2024: 38 · 2023: 45 · 2022: 39 · 2021: 48 · 2020: 58 · 2019: 54 · 2018: 54 · 2017: 48 · 2016: 55 · 2015: 50 · 2014: 45 · 2013: 46 · 2012: 41
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB008260)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Biomedical Engineering › Nanowire Synthesis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- nanowire field-effect transistors, Debye length, label-free detection, macromolecule binding, selective detection, channel electric field
- MeSH terms
- Biotechnology, DNA, DNA, Single-Stranded, Light, Microscopy, Electron, Scanning, Microscopy, Fluorescence, Molecular Conformation, Temperature, Transistors, Electronic, Models, Statistical, Biosensing Techniques, Streptavidin, Nanotechnology, Macromolecular Substances, Nanowires
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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