The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tuning payload delivery in tumour cylindroids using gold nanoparticles
Open accessAbstract
Nanoparticles have great potential as controllable drug delivery vehicles because of their size and modular functionality. Timing and location are important parameters when optimizing nanoparticles for delivery of chemotherapeutics. Here we show that positively- and negatively-charged gold nanoparticles carrying either fluorescein or doxorubicin molecules move and localize differently in an in vitro three dimensional model of tumour tissue. Fluorescence microcopy and mathematical modelling showed that uptake, and not diffusion, is the dominant mechanism in particle delivery. Our results suggest that positive particles may be more effective for drug delivery because they are more significantly taken up by proliferating cells. Negative particles, which diffused faster, may perform better when delivering drugs deep into the tissues. An understanding of how surface charge can control tissue penetration and drug release may overcome some of the current limitations in drug delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Drug penetration in solid tumours
Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805
Drug Resistance and the Solid Tumor Microenvironment
Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · cited 1×
“These populations are often unresponsive to standard therapy because of their distance from blood vessels and resistance to molecular uptak”
BackgroundCell and environment interactions in tumor microregions: the multicell spheroid model.
Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803
Cited by
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation
Deng, Z. J., Liang, M., Monteiro, M., Toth, I., & Minchin, R. F. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.250 · Cited by 893
Wang, F., Wang, Y.-C., Dou, S., Xiong, M.-H., Sun, T.-M., & Wang, J. (2011) · ACS Nano · doi:10.1021/nn200007z · Cited by 813
Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-Based Nanoparticles
Yue, Z.-G., Wei, W., Lv, P.-P., Yue, H., Wang, L.-Y., Su, Z.-G., & Ma, G.-H. (2011) · Biomacromolecules · doi:10.1021/bm101482r · Cited by 567
Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
Pinto, B., Henriques, A. C., Silva, P. M. A., & Bousbaa, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121186 · Cited by 440
Metadata
- Authors
- Kim, B., Han, G., Toley, B. J., Kim, C.-K., Rotello, V. M., & Forbes, N. S.
- Venue
- Nature Nanotechnology
- Published
- 2010-04-11
- Volume
- 5
- Issue
- 6
- Pages
- 465-472
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2034618316
- Cited by
- 479
- References
- 3
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tuning payload delivery in tumour cylindroids using gold nanoparticles. https://app.cochat.ai/papers/10.1038/nnano.2010.58
- The paper
- Kim, B., Han, G., Toley, B. J., Kim, C.-K., Rotello, V. M., & Forbes, N. S. (2010). Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nature Nanotechnology. https://doi.org/10.1038/nnano.2010.58
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
