Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

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The Tumor Microenvironment Innately Modulates Cancer Progression

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Role of hypoxia in cancer therapy by regulating the tumor microenvironment

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Tumor microenvironment and therapeutic response

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Cancer immunoediting and resistance to T cell-based immunotherapy

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Modeling Tissue Morphogenesis and Cancer in 3D

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Multicellular tumor spheroids: An underestimated tool is catching up again

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Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

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Can Animal Models of Disease Reliably Inform Human Studies?

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Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

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3D Cell Culture Systems: Advantages and Applications

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Targeting Tumor Microenvironment for Cancer Therapy

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Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

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3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

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Spherical Cancer Models in Tumor Biology

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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

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Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

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Three-Dimensional Cell Culture: A Breakthrough in Vivo

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3D tumor spheroids: an overview on the tools and techniques used for their analysis

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Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines

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Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

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Three-Dimensional Cell Cultures in Drug Discovery and Development

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Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

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Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

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A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

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Extracellular matrix (ECM) stiffness and degradation as cancer drivers

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Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke

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Tumor-Associated Macrophages: Recent Insights and Therapies

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Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke

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Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems

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Advances in the formation, use and understanding of multi-cellular spheroids

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Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

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Possible Future Issues in the Treatment of Glioblastomas: Special Emphasis on Cell Migration and the Resistance of Migrating Glioblastoma Cells to Apoptosis

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Spheroid Culture System Methods and Applications for Mesenchymal Stem Cells

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High drug attrition rates—where are we going wrong?

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Targeting the microenvironment in solid tumors

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Tuning payload delivery in tumour cylindroids using gold nanoparticles

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Fluorescent Nanorods and Nanospheres for Real‐Time In Vivo Probing of Nanoparticle Shape‐Dependent Tumor Penetration

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Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

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The production of 3D tumor spheroids for cancer drug discovery

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Tumor microenvironment: recent advances in various cancer treatments.

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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

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Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

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Spatial Heterogeneity in the Tumor Microenvironment

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Metabolism shapes the tumor microenvironment

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Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

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Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors

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Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

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Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model

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Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer

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Three-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation

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Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

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Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles

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