The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population
Open accessAbstract
Nanoparticles are considered a primary vehicle for targeted therapies because they can pass biological barriers and enter and distribute within cells by energy-dependent pathways. So far, most studies have shown that nanoparticle properties, such as size and surface, can influence how cells internalize nanoparticles. Here, we show that uptake of nanoparticles by cells is also influenced by their cell cycle phase. Although cells in different phases of the cell cycle were found to internalize nanoparticles at similar rates, after 24 h the concentration of nanoparticles in the cells could be ranked according to the different phases: G2/M > S > G0/G1. Nanoparticles that are internalized by cells are not exported from cells but are split between daughter cells when the parent cell divides. Our results suggest that future studies on nanoparticle uptake should consider the cell cycle, because, in a cell population, the dose of internalized nanoparticles in each cell varies as the cell advances through the cell cycle.
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Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Cited by
Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912
Self-citationBarua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,257
Lesniak, A., Fenaroli, F., Monopoli, M. P., Åberg, C., Dawson, K. A., & Salvati, A. (2012) · ACS Nano · doi:10.1021/nn300223w · Cited by 1,020
Self-citationMinimum information reporting in bio–nano experimental literature
Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0246-4 · Cited by 710
Neural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655
Metadata
- Authors
- Kim, J. A., Åberg, C., Salvati, A., & Dawson, K. A.
- Venue
- Nature Nanotechnology
- Published
- 2011-11-06
- Volume
- 7
- Issue
- 1
- Pages
- 62-68
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2153028101
- Cited by
- 655
- References
- 1
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, J. A., Åberg, C., Salvati, A., & Dawson, K. A. (2012). Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population. Nature Nanotechnology. https://doi.org/10.1038/nnano.2011.191
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