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Cited by 366Plasmonic and Surface Plasmon ResearchGold and Silver Nanoparticles Synthesis and ApplicationsAdvanced Fluorescence Microscopy Techniques

Single-Molecule Plasmon Sensing: Current Status and Future Prospects

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Taylor, Adam B., Zijlstra, Peter·2017·ACS Sensors
DOI 10.1021/acssensors.7b00382PMC PMC5573902
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Abstract

Single-molecule detection has long relied on fluorescent labeling with high quantum-yield fluorophores. Plasmon-enhanced detection circumvents the need for labeling by allowing direct optical detection of weakly emitting and completely nonfluorescent species. This review focuses on recent advances in single molecule detection using plasmonic metal nanostructures as a sensing platform, particularly using a single particle?single molecule approach. In the past decade two mechanisms for plasmon-enhanced single-molecule detection have been demonstrated: (1) by plasmonically enhancing the emission of weakly fluorescent biomolecules, or (2) by monitoring shifts of the plasmon resonance induced by single-molecule interactions. We begin with a motivation regarding the importance of single molecule detection, and advantages plasmonic detection offers. We describe both detection mechanisms and discuss challenges and potential solutions. We finalize by highlighting the exciting possibilities in analytical chemistry and medical diagnostics.

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  • The dependence of plasmon resonance on the refractive index of the medium can be exploited for optical sensing applications, even at single molecule level, as long as molecules cause a variation of the refractive index.

    “The above mentioned dependence of the plasmon resonance on the refractive index of the medium can be exploited for optical sensing applications [163], even at a single molecule level [164,165], as it allows the detection of molecules dissolved in the colloidal phase or adsorbed on the surface, as long as they cause a variation of the refractive index of the medium [166,167].”

    From Nanoparticles Engineering by Pulsed Laser Ablation in Liquids: Concepts and Applications (2020) · cites this paper as [166]

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Cited by

Sorted by citations

Authors
Taylor, A. B., & Zijlstra, P.
Affiliations
Eindhoven University of Technology (NL)
Corresponding author
Zijlstra, Peter
ORCID
Venue
ACS Sensors
Publisher
American Chemical Society (ACS)
Published
2017-08-01
Volume
2
Issue
8
Pages
1103-1122
ISSN
2379-3694 (ISSN-L)
DOI
10.1021/acssensors.7b00382
PMC
PMC5573902
OpenAlex
W2739705061
Cited by
366
References
2
Citations by year
2026: 17 · 2025: 38 · 2024: 39 · 2023: 43 · 2022: 46 · 2021: 53 · 2020: 45 · 2019: 45 · 2018: 35 · 2017: 4 · 2016: 1
FWCI
15.89
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Sensors (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • TU/e Research Portal (submittedVersion, other-oa)
  • TU/e Research Portal (submittedVersion)
Funders
  • Stichting voor Fundamenteel Onderzoek der Materie (14PR3160)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (VIDI 680-47-530)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Keywords
single-molecule detection, plasmon resonance shift, label-free detection, plasmon-enhanced fluorescence, medical diagnostics, analytical chemistry

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