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Shear-stress sensitive lenticular vesicles for targeted drug delivery
Open accessAbstract
Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress.
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Clerc, S., & Barenholz, Y. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00214-6 · Cited by 145
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Sun, X., Wang, G., Zhang, H., Hu, S., Liu, X., Tang, J., & Shen, Y. (2018) · ACS Nano · doi:10.1021/acsnano.8b02830 · Cited by 253
Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release
Wang, J., Kaplan, J. A., Colson, Y. L., & Grinstaff, M. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.001 · Cited by 126
Metadata
- Authors
- Holme, M. N., Fedotenko, I. A., Abegg, D., Althaus, J., Babel, L., Favarger, F., Reiter, R., Tanasescu, R., Zaffalon, P.-L., Ziegler, A., Müller, B., Saxer, T., & Zumbuehl, A.
- Venue
- Nature Nanotechnology
- Published
- 2012-06-10
- Volume
- 7
- Issue
- 8
- Pages
- 536-543
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2084621221
- Cited by
- 289
- References
- 2
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Holme, M. N., Fedotenko, I. A., Abegg, D., Althaus, J., Babel, L., Favarger, F., Reiter, R., Tanasescu, R., Zaffalon, P.-L., Ziegler, A., Müller, B., Saxer, T., & Zumbuehl, A. (2012). Shear-stress sensitive lenticular vesicles for targeted drug delivery. Nature Nanotechnology. https://doi.org/10.1038/nnano.2012.84
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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