The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
Open accessAbstract
The spread of cancer throughout the body is driven by circulating tumour cells (CTCs)1. These cells detach from the primary tumour and move from the blood stream to a new site of subsequent tumour growth. They also carry information about the primary tumour and have the potential to be valuable biomarkers for disease diagnosis and progression, and for the molecular characterization of certain biological properties of the tumour. However, the limited sensitivity and specificity of current methods to measure and study these cells in patient blood samples prevent the realization of their full clinical potential. The use of microfluidic devices is a promising method for isolating CTCs2, 3; however, the devices are reliant on three-dimensional structures, which limit further characterization and expansion of cells on the chip. Here we demonstrate an effective approach to isolate CTCs from blood samples of pancreatic, breast and lung cancer patients, by using functionalised graphene oxide nanosheets on a patterned gold surface. CTCs were captured with high sensitivity at low concentration of target cells (73% ± 32.4 at 3–5 cells/mL blood).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The chemistry of graphene oxide
Dreyer, D. R., Park, S., Bielawski, C. W., & Ruoff, R. S. (2010) · Chem. Soc. Rev. · doi:10.1039/b917103g · Cited by 11,653
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617
Self-citationKrebs, M. G., Hou, J.-M., Sloane, R., Lancashire, L., Priest, L., Nonaka, D., Ward, T. H., Backen, A., Clack, G., Hughes, A., et al. (2012) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31823c5c16 · Cited by 463
Cited by
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Current detection technologies for circulating tumor cells
Shen, Z., Wu, A., & Chen, X. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00803h · Cited by 433
Technologies for circulating tumor cell separation from whole blood
Bankó, P., Lee, S. Y., Nagygyörgy, V., Zrínyi, M., Chae, C. H., Cho, D. H., & Telekes, A. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0735-4 · Cited by 358
Engineering and physical sciences in oncology: challenges and opportunities
Mitchell, M. J., Jain, R. K., & Langer, R. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.83 · Cited by 273
Park, M.-H., Reátegui, E., Li, W., Tessier, S. N., Wong, K. H. K., Jensen, A. E., Thapar, V., Ting, D., Toner, M., Stott, S. L., et al. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b12236 · Cited by 267
Metadata
- Authors
- Yoon, H. J., Kim, T. H., Zhang, Z., Azizi, E., Pham, T. M., Paoletti, C., Lin, J., Ramnath, N., Wicha, M. S., Hayes, D. F., Simeone, D. M., & Nagrath, S.
- Venue
- Nature Nanotechnology
- Published
- 2013-09-29
- Volume
- 8
- Issue
- 10
- Pages
- 735-741
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W1986688132
- Cited by
- 534
- References
- 4
- FWCI
- 26.57
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. https://app.cochat.ai/papers/10.1038/nnano.2013.194
- The paper
- Yoon, H. J., Kim, T. H., Zhang, Z., Azizi, E., Pham, T. M., Paoletti, C., Lin, J., Ramnath, N., Wicha, M. S., Hayes, D. F., Simeone, D. M., & Nagrath, S. (2013). Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nature Nanotechnology. https://doi.org/10.1038/nnano.2013.194
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
