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A biomimetic nanosponge that absorbs pore-forming toxins
Open accessAbstract
Detoxification treatments such as toxin-targeted anti-virulence therapy1, 2 offer ways to cleanse the body of virulence factors that are caused by bacterial infections, venomous injuries, and biological weaponry. Because existing detoxification platforms such as antisera3, monoclonal antibodies4, small-molecule inhibitors5, 6, and molecularly imprinted polymers7 act by targeting the molecular structures of the toxins, customized treatments are required for different diseases. Here we show a biomimetic toxin nanosponge that functions as a toxin decoy in vivo. The nanosponge, which consists of a polymeric nanoparticle core surrounded by red blood cell membranes, absorbs membrane-damaging toxins and diverts them away from their cellular targets. In a mouse model, the nanosponges markedly reduce the toxicity of staphylococcal alpha-hemolysin (α-toxin) and thus improve the survival rate of toxin-challenged mice. This biologically inspired toxin nanosponge presents a detoxification treatment that can potentially treat a variety of injuries and diseases caused by pore-forming toxins.
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Cited by
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Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Self-citationChen, Z., Zhao, P., Luo, Z., Zheng, M., Tian, H., Gong, P., Gao, G., Pan, H., Liu, L., Ma, A., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b04695 · Cited by 895
Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483
Cell or Cell Membrane-Based Drug Delivery Systems
Tan, S., Wu, T., Zhang, D., & Zhang, Z. (2015) · Theranostics · doi:10.7150/thno.11852 · Cited by 466
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
Metadata
- Authors
- Hu, C.-M. J., Fang, R. H., Copp, J., Luk, B. T., & Zhang, L.
- Venue
- Nature Nanotechnology
- Published
- 2013-04-14
- Volume
- 8
- Issue
- 5
- Pages
- 336-340
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2042634738
- Cited by
- 751
- References
- 0
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Hu, C.-M. J., Fang, R. H., Copp, J., Luk, B. T., & Zhang, L. (2013). A biomimetic nanosponge that absorbs pore-forming toxins. Nature Nanotechnology. https://doi.org/10.1038/nnano.2013.54
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