The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways
Open accessAbstract
Nanoscale drug delivery vehicles can facilitate multimodal therapies of cancer by promoting tumour-selective drug release. However, few are effective because cancer cells develop ways to resist and evade treatment. Here, we introduce a photoactivatable multi-inhibitor nanoliposome (PMIL) that imparts light-induced cytotoxicity in synchrony with photo-initiated and sustained release of inhibitors that suppress tumour regrowth and treatment escape signalling pathways. The PMIL consists of a nanoliposome doped with a photoactivatable chromophore (benzoporphyrin derivative, BPD) in the lipid bilayer, and a nanoparticle containing cabozantinib (XL184)—a multikinase inhibitor—encapsulated inside. Near infrared tumour irradiation, following intravenous PMIL administration, triggers photodynamic damage of tumour cells and microvessels, and simultaneously initiates release of XL184 inside the tumour. A single PMIL treatment achieves prolonged tumour reduction in two mouse models and suppresses metastatic escape in an orthotopic pancreatic tumour model. The PMIL offers new prospects for cancer therapy by enabling spatiotemporal control of drug release whilst reducing systemic drug exposure and associated toxicities.
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Cites
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Cancer drug resistance: an evolving paradigm
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Inhibition of c-Met Reduces Lymphatic Metastasis in RIP-Tag2 Transgenic Mice
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Cited by
Stimuli‐responsive liposomes for drug delivery
Lee, Y., & Thompson, D. H. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1450 · Cited by 579
Titanium-Based Nanoscale Metal–Organic Framework for Type I Photodynamic Therapy
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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
Kolarikova, M., Hosikova, B., Dilenko, H., Barton‐Tomankova, K., Valkova, L., Bajgar, R., Malina, L., & Kolarova, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21935 · Cited by 282
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Metadata
- Authors
- Spring, B. Q., Bryan Sears, R., Zheng, L. Z., Mai, Z., Watanabe, R., Sherwood, M. E., Schoenfeld, D. A., Pogue, B. W., Pereira, S. P., Villa, E., & Hasan, T.
- Venue
- Nature Nanotechnology
- Published
- 2016-01-18
- Volume
- 11
- Issue
- 4
- Pages
- 378-387
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2256387072
- Cited by
- 243
- References
- 6
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Spring, B. Q., Bryan Sears, R., Zheng, L. Z., Mai, Z., Watanabe, R., Sherwood, M. E., Schoenfeld, D. A., Pogue, B. W., Pereira, S. P., Villa, E., & Hasan, T. (2016). A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways. Nature Nanotechnology. https://doi.org/10.1038/nnano.2015.311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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