The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A STING-activating nanovaccine for cancer immunotherapy
Open accessAbstract
Generation of tumor-specific T cells is critically important for cancer immunotherapy1,2. A major challenge in achieving a robust T cell response is the spatio-temporal orchestration of antigen cross-presentation in antigen presenting cells (APCs) with innate stimulation. Here we report a minimalist nanovaccine by a simple physical mixture of an antigen with a synthetic polymeric nanoparticle, PC7A NP, which generated a strong cytotoxic T cell response with low systemic cytokine expression. Mechanistically, PC7A NP achieved efficient cytosolic delivery of tumor antigens to APCs in draining lymph nodes leading to increased surface presentation while simultaneously activating type I interferon-stimulated genes. This effect was dependent on STING but not Toll-like receptor or MAVS pathway. Nanovaccine produced potent tumor growth inhibition in melanoma, colon cancer, and human papilloma virus-E6/E7 tumor models. Combination of PC7A nanovaccine with an anti-PD-1 antibody showed great synergy with 100% survival over 60 days in a TC-1 tumor model. Rechallenging of these tumor-free animals with TC-1 cells led to complete inhibition of tumor growth, suggesting generation of long-term antitumor memory. The STING-activating nanovaccine offers a simple, safe and robust strategy in boosting anti-tumor immunity for cancer immunotherapy.
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Cited by
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
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Recent progress in drug delivery
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Metadata
- Authors
- Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y.-X., Chen, Z. J., & Gao, J.
- Venue
- Nature Nanotechnology
- Published
- 2017-04-24
- Volume
- 12
- Issue
- 7
- Pages
- 648-654
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2606608340
- Cited by
- 900
- References
- 10
- FWCI
- 26.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., Porembka, M. R., Lea, J., Frankel, A. E., Fu, Y.-X., Chen, Z. J., & Gao, J. (2017). A STING-activating nanovaccine for cancer immunotherapy. Nature Nanotechnology. https://doi.org/10.1038/nnano.2017.52
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
