The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Piggyback-the-Winner in host-associated microbial communities
Open accessAbstract
Phages can exploit their bacterial hosts by lytic infection, when many viral particles are released at cell lysis, or by lysogeny, when phages integrate into the host’s genome. We recently proposed a new dynamic model of bacteria–phage interactions in which lysogeny predominates at high microbial abundance and growth rates. This model, named Piggyback-the-Winner (PtW), contrasts to current accepted models on the frequency of lysis and lysogeny and predicts that phages integrate into their hosts’ genomes as prophages when microbial abundances and growth rates are high. According to PtW, switching to the temperate life cycle reduces phage predation control on bacterial abundance and confers superinfection exclusion, preventing that a closely-related phage infects the same bacterial cell. Here we examine how PtW is important for metazoans. Specifically, we postulate that PtW and the recently described bacteriophage adherence to mucus (BAM) model are strongly interrelated and have an important role in the development of the microbiome. In BAM, phage produced by the microbiome attach to mucins and protect underlying epithelial cells from invading bacteria. Spatial structuring of the mucus creates a gradient of phage replication strategies consistent with PtW. We predict that lysogeny is favored at the top mucosal layer and lytic predation predominates in the bacteria-sparse intermediary layers. The lysogeny confers competitive advantage to commensals against niche invasion and the lytic infection eliminates potential pathogens from deeper mucus layers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Diversity and distribution of coral-associated bacteria
Rohwer, F., Seguritan, V, Azam, F., & Knowlton, N. (2002) · Marine Ecology Progress Series · doi:10.3354/meps243001 · Cited by 1,337
Self-citationSingle-cell genome sequencing: current state of the science
Gawad, C., Koh, W., & Quake, S. R. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2015.16 · Cited by 1,334
The bioenergetic costs of a gene
Lynch, M., & Marinov, G. K. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514974112 · Cited by 600
Quantitative imaging of gut microbiota spatial organization
Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., & Sonnenburg, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.002 · Cited by 433
Role of Multicellular Aggregates in Biofilm Formation
Kragh, K. N., Hutchison, J. B., Melaugh, G., Rodesney, C., Roberts, A. E. L., Irie, Y., Jensen, P. Ø., Diggle, S. P., Allen, R. J., Gordon, V., et al. (2016) · mBio · doi:10.1128/mbio.00237-16 · Cited by 350
Spatial distribution of microbial communities in the cystic fibrosis lung
Willner, D., Haynes, M. R., Furlan, M., Schmieder, R., Lim, Y. W., Rainey, P. B., Rohwer, F., & Conrad, D. (2012) · The ISME Journal · doi:10.1038/ismej.2011.104 · Cited by 177
Self-citationQuinn, R. A., Lim, Y. W., Maughan, H., Conrad, D., Rohwer, F., & Whiteson, K. L. (2014) · mBio · doi:10.1128/mbio.00956-13 · Cited by 115
Self-citation
Cited by
The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific
Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F. J., Daly, K. M., Nolan, J. A., McDonnell, S. A., Khokhlova, E. V., Draper, L. A., Forde, A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.09.009 · Cited by 737
Voolstra, C. R., & Ziegler, M. (2020) · BioEssays · doi:10.1002/bies.202000004 · Cited by 303
Functional Strain Redundancy and Persistent Phage Infection in Swiss Hard Cheese Starter Cultures
Somerville, V., Berthoud, H., Schmidt, R. S., Bachmann, H.-P., Meng, Y. H., Fuchsmann, P., von Ah, U., & Engel, P. (2022) · The ISME Journal · doi:10.1038/s41396-021-01071-0 · Cited by 55
Effects of bacteriophages on gut microbiome functionality
Kurilovich, E., & Geva-Zatorsky, N. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2481178 · Cited by 51
Tomofuji, Y., Kishikawa, T., Maeda, Y., Ogawa, K., Otake-Kasamoto, Y., Kawabata, S., Nii, T., Okuno, T., Oguro-Igashira, E., Kinoshita, M., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100219 · Cited by 35
Metadata
- Authors
- Silveira, C. B., & Rohwer, F. L.
- Venue
- npj Biofilms and Microbiomes
- Published
- 2016-07-06
- Volume
- 2
- Issue
- 1
- Pages
- 16010-16010
- ISSN
- 2055-5008 (ISSN-L)
- OpenAlex
- W2468409351
- Cited by
- 341
- References
- 8
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Piggyback-the-Winner in host-associated microbial communities. https://app.cochat.ai/papers/10.1038/npjbiofilms.2016.10
- The paper
- Silveira, C. B., & Rohwer, F. L. (2016). Piggyback-the-Winner in host-associated microbial communities. npj Biofilms and Microbiomes. https://doi.org/10.1038/npjbiofilms.2016.10
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
