The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1
Open accessAbstract
In Arabidopsis the plasma membrane nitrate transceptor (transporter/receptor) NRT1.1 governs many physiological and developmental responses to nitrate. Alongside facilitating nitrate uptake, NRT1.1 regulates the expression levels of many nitrate assimilation pathway genes, modulates root system architecture, relieves seed dormancy and protects plants from ammonium toxicity. Here, we assess the functional and phenotypic consequences of point mutations in two key residues of NRT1.1 (P492 and T101). We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. We also show that these mutations have differential effects on genome-wide gene expression. Our findings indicate that NRT1.1 activates four separate signalling mechanisms, which have independent structural bases in the protein. In particular, we present evidence to suggest that the phosphorylated and non-phosphorylated forms of NRT1.1 at T101 have distinct signalling functions, and that the nitrate-dependent regulation of root development depends on the phosphorylated form. Our findings add to the evidence that NRT1.1 is able to trigger independent signalling pathways in Arabidopsis in response to different environmental conditions.
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Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,633
CHL1 Functions as a Nitrate Sensor in Plants
Ho, C.-H., Lin, S.-H., Hu, H.-C., & Tsay, Y.-F. (2009) · Cell · doi:10.1016/j.cell.2009.07.004 · Cited by 1,329
Nitrate-Regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants
Krouk, G., Lacombe, B., Bielach, A., Perrine-Walker, F., Malinska, K., Mounier, E., Hoyerova, K., Tillard, P., Leon, S., Ljung, K., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.008 · Cited by 1,054
Self-citationNemhauser, J. L., Hong, F., & Chory, J. (2006) · Cell · doi:10.1016/j.cell.2006.05.050 · Cited by 947
The herbicide sensitivity gene CHL1 of arabidopsis encodes a nitrate-inducible nitrate transporter
Tsay, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90399-b · Cited by 817
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Wang, Y.-Y., Hsu, P.-K., & Tsay, Y.-F. (2012) · Trends in Plant Science · doi:10.1016/j.tplants.2012.04.006 · Cited by 703
A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family members in plants
Léran, S., Varala, K., Boyer, J.-C., Chiurazzi, M., Crawford, N., Daniel-Vedele, F., David, L., Dickstein, R., Fernandez, E., Forde, B., et al. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2013.08.008 · Cited by 676
Self-citationRubin, G., Tohge, T., Matsuda, F., Saito, K., & Scheible, W.-R. (2009) · The Plant Cell · doi:10.1105/tpc.109.067041 · Cited by 647
Remans, T., Nacry, P., Pervent, M., Filleur, S., Diatloff, E., Mounier, E., Tillard, P., Forde, B. G., & Gojon, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605275103 · Cited by 554
Self-citationGravity-regulated differential auxin transport from columella to lateral root cap cells
Ottenschläger, I., Wolff, P., Wolverton, C., Bhalerao, R. P., Sandberg, G., Ishikawa, H., Evans, M., & Palme, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437936100 · Cited by 549
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Zayed, O., Hewedy, O. A., Abdelmoteleb, A., Ali, M., Youssef, M. S., Roumia, A. F., Seymour, D., & Yuan, Z.-C. (2023) · Biomolecules · doi:10.3390/biom13101443 · Cited by 412
Plant nitrate transporters: from gene function to application
Fan, X., Naz, M., Fan, X., Xuan, W., Miller, A. J., & Xu, G. (2017) · Journal of Experimental Botany · doi:10.1093/jxb/erx011 · Cited by 365
The Cytoskeleton and Its Regulation by Calcium and Protons
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Beneficial soil-borne bacteria and fungi: a promising way to improve plant nitrogen acquisition
Dellagi, A., Quillere, I., & Hirel, B. (2020) · Journal of Experimental Botany · doi:10.1093/jxb/eraa112 · Cited by 116
Chen, Y., Li, Y., Fu, Y., Jia, L., Li, L., Xu, Z., Zhang, N., Liu, Y., Fan, X., Xuan, W., et al. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae125 · Cited by 31
Metadata
- Authors
- Bouguyon, E., Brun, F., Meynard, D., Kubeš, M., Pervent, M., Leran, S., Lacombe, B., Krouk, G., Guiderdoni, E., Zažímalová, E., Hoyerová, K., Nacry, P., & Gojon, A.
- Venue
- Nature Plants
- Published
- 2015-03-02
- Volume
- 1
- Issue
- 3
- Pages
- 15015-15015
- ISSN
- 2055-026X (ISSN-L)
- 2055-0278
- OpenAlex
- W2064061294
- Cited by
- 353
- References
- 28
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Bouguyon, E., Brun, F., Meynard, D., Kubeš, M., Pervent, M., Leran, S., Lacombe, B., Krouk, G., Guiderdoni, E., Zažímalová, E., Hoyerová, K., Nacry, P., & Gojon, A. (2015). Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1. Nature Plants. https://doi.org/10.1038/nplants.2015.15
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