The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Members of the LBD Family of Transcription Factors Repress Anthocyanin Synthesis and Affect Additional Nitrogen Responses in Arabidopsis
Open accessAbstract
Nitrogen (N) and nitrate (NO3 −) per se regulate many aspects of plant metabolism, growth, and development. N/NO3 − also suppresses parts of secondary metabolism, including anthocyanin synthesis. Molecular components for this repression are unknown. We report that three N/NO3 −-induced members of the LATERAL ORGAN BOUNDARY DOMAIN (LBD) gene family of transcription factors (LBD37, LBD38, and LBD39) act as negative regulators of anthocyanin biosynthesis in Arabidopsis thaliana. Overexpression of each of the three genes in the absence of N/NO3 − strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production. Conversely, lbd37, lbd38, or lbd39 mutants accumulate anthocyanins when grown in N/NO3 −-sufficient conditions and show constitutive expression of anthocyanin biosynthetic genes. The LBD genes also repress many other known N-responsive genes, including key genes required for NO3 − uptake and assimilation, resulting in altered NO3 − content, nitrate reductase activity/activation, protein, amino acid, and starch levels, and N-related growth phenotypes. The results identify LBD37 and its two close homologs as novel repressors of anthocyanin biosynthesis and N availability signals in general. They also show that, besides being developmental regulators, LBD genes fulfill roles in metabolic regulation.
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Cites
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Strigolactone inhibition of shoot branching
Gomez-Roldan, V., Fermas, S., Brewer, P. B., Puech-Pagès, V., Dun, E. A., Pillot, J.-P., Letisse, F., Matusova, R., Danoun, S., Portais, J.-C., et al. (2008) · Nature · doi:10.1038/nature07271 · Cited by 2,281
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Umehara, M., Hanada, A., Yoshida, S., Akiyama, K., Arite, T., Takeda-Kamiya, N., Magome, H., Kamiya, Y., Shirasu, K., Yoneyama, K., et al. (2008) · Nature · doi:10.1038/nature07272 · Cited by 2,105
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Arabidopsis JAGGED LATERAL ORGANS Is Expressed in Boundaries and Coordinates KNOX and PIN Activity
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“…are required for auxin-dependent lateral root formation (Okushima et al., 2007), LBD18 and LBD30 were shown to regulate tracheary element differentiation in Arabidopsis (Soyano et al., 2008), and LBD30/JAGGED LATERAL ORGANS is essential for Arabidopsis embryo development (Borghi et al., 2007).”
Background
Cited by
Plant Nitrogen Assimilation and Use Efficiency
Xu, G., Fan, X., & Miller, A. J. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105532 · Cited by 2,114
Arabidopsis NIN-like transcription factors have a central role in nitrate signalling
Konishi, M., & Yanagisawa, S. (2013) · Nature Communications · doi:10.1038/ncomms2621 · Cited by 470
Genomic basis of geographical adaptation to soil nitrogen in rice
Liu, Y., Wang, H., Jiang, Z., Wang, W., Xu, R., Wang, Q., Zhang, Z., Li, A., Liang, Y., Ou, S., et al. (2021) · Nature · doi:10.1038/s41586-020-03091-w · Cited by 468
Nitrogen Journey in Plants: From Uptake to Metabolism, Stress Response, and Microbe Interaction
Zayed, O., Hewedy, O. A., Abdelmoteleb, A., Ali, M., Youssef, M. S., Roumia, A. F., Seymour, D., & Yuan, Z.-C. (2023) · Biomolecules · doi:10.3390/biom13101443 · Cited by 412
Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1
Bouguyon, E., Brun, F., Meynard, D., Kubeš, M., Pervent, M., Leran, S., Lacombe, B., Krouk, G., Guiderdoni, E., Zažímalová, E., et al. (2015) · Nature Plants · doi:10.1038/nplants.2015.15 · Cited by 353
Metadata
- Authors
- Rubin, G., Tohge, T., Matsuda, F., Saito, K., & Scheible, W.-R.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-01
- Volume
- 21
- Issue
- 11
- Pages
- 3567-3584
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2119099372
- Cited by
- 647
- References
- 7
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rubin, G., Tohge, T., Matsuda, F., Saito, K., & Scheible, W.-R. (2009). Members of the LBD Family of Transcription Factors Repress Anthocyanin Synthesis and Affect Additional Nitrogen Responses in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.109.067041
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