The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Effects of Acute Stimulant Medication on Cerebral Metabolism in Adults with Hyperactivity
Abstract
Recent work in our laboratory has demonstrated both global and regional reductions in cerebral glucose metabolism in adult subjects with attention-deficit hyperactivity disorder (ADHD). The purpose of the present study was to examine the effects of an acute dose of stimulant medication on cerebral metabolism in adults with ADHD using positron emission tomography with fluorodeoxyglucose-18 as the tracer. Each subject underwent scanning twice, once off-drug and again after receiving a single oral dose of either dextroamphetamine (0.25 mg/kg) or methylphenidate (0.35 mg/kg). Subjects completed behavioral self-report measures before and after the scan and performed an auditory continuous performance task during the tracer uptake period. Neither drug changed global metabolism. Both drugs increased systolic blood pressure, and dextroamphetamine improved performance on the auditory attention task. Each stimulant produced a differential pattern of increases and decreases in regional metabolism throughout the regions of interest that were sampled. Rather than increasing glucose utilization in specific brain regions with lowered metabolic rates in adults with ADHD, stimulants may act by altering glucose use throughout the brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“treatment with methylphenidate normalizes the hypoperfusion of prefrontal areas and is associated with corresponding improvement in ADHD symptoms [60][61][62][63][64][65].”
From Adult ADHD and comorbid disorders: clinical implications of a dimensional approach (2017) · cites this paper as [62]
Citations
Cites
(1970) · Cited by 24,983
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603
Essentials of Behavioral Research: Methods and Data Analysis
Rosenthal, R., & Rosnow, R. L. (1984) · Cited by 3,925
Phelps, M. E., Huang, S. C., Hoffman, E. J., Selin, C. E., Sokoloff, L., & Kuhl, D. E. (1979) · Annals of Neurology · doi:10.1002/ana.410060502 · Cited by 2,417
Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
Zametkin, A. J., NORDAHL, T. E., Gross, M., King, A. C., Semple, W. E., Rumsey, J. M., Hamburger, S., & Cohen, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232001 · Cited by 975
Self-citationNoninvasive determination of local cerebral metabolic rate of glucose in man
Huang, S. C., Phelps, M. E., Hoffman, E. J., Sideris, K., Selin, C. J., & Kuhl, D. E. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.1.e69 · Cited by 926
WEISS, G., HECHTMAN, L., MILROY, T., & PERLMAN, T. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60450-7 · Cited by 753
Striatal Dysfunction in Attention Deficit and Hyperkinetic Disorder
LOU, H. C., Henriksen, L., Bruhn, P. J., Borner, H., & Nielsen, J. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520370050018 · Cited by 546
A REVIEW OF STIMULANT DRUG RESEARCH WITH HYPERACTIVE CHILDREN
Barkley, R. A. (1977) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1977.tb00425.x · Cited by 542
An Atlas of the Human Brain for Computerized Tomography.
Cooper, P. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-5-733_1 · Cited by 466
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–106 of 106
Tucker, D. M., Holahan, C. J., Carlson, C. L., Diehl, R. L., Maedgen, J. W., Churchill, W., Mosko, S. S., & Mosko, M. S. (2007)
Neurodevelopmental and Neuropsychiatric Disorders
Glanzman, M. M., & Elia, J. (2006) · Springer eBooks · doi:10.1007/0-387-34641-4_19
SECTION C. The Assessment Process: Differential Diagnosis
Fisher, B. C. (2006) · CRC Press eBooks · doi:10.3109/9781420004724-41
Schuckit, M. A. (2000) · Springer eBooks · doi:10.1007/978-1-4757-3232-0_5
Schuckit, M. A. (1995) · Springer eBooks · doi:10.1007/978-1-4757-2407-3_5
Marazziti, D., & Mucci, F. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726867804.793557955
Metadata
- Authors
- Matochik, J. A., Nordahl, T. E., Gross, M., Semple, W. E., King, A. C., Cohen, R. M., & Zametkin, A. J.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Nordahl, Thomas E.
- Venue
- Neuropsychopharmacology
- Published
- 1993-06
- Volume
- 8
- Issue
- 4
- Pages
- 377-386
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2076168139
- Cited by
- 105
- References
- 26
- Citations by year
- 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, adult ADHD, stimulant medication, d-amphetamine, methylphenidate, brain glucose metabolism, regional brain metabolism, auditory attention, blood pressure
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Behavior, Brain, Dextroamphetamine, Female, Humans, Male, Methylphenidate, Middle Aged, Task Performance and Analysis, Tomography, Emission-Computed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
