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Cited by 106Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Effects of Acute Stimulant Medication on Cerebral Metabolism in Adults with Hyperactivity

Matochik, John A., Nordahl, Thomas E., Gross, Michael, Semple, William E., King, A. Catherine, Cohen, Robert M., Zametkin, Alan J.·1993·Neuropsychopharmacology
DOI 10.1038/npp.1993.38
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Abstract

Recent work in our laboratory has demonstrated both global and regional reductions in cerebral glucose metabolism in adult subjects with attention-deficit hyperactivity disorder (ADHD). The purpose of the present study was to examine the effects of an acute dose of stimulant medication on cerebral metabolism in adults with ADHD using positron emission tomography with fluorodeoxyglucose-18 as the tracer. Each subject underwent scanning twice, once off-drug and again after receiving a single oral dose of either dextroamphetamine (0.25 mg/kg) or methylphenidate (0.35 mg/kg). Subjects completed behavioral self-report measures before and after the scan and performed an auditory continuous performance task during the tracer uptake period. Neither drug changed global metabolism. Both drugs increased systolic blood pressure, and dextroamphetamine improved performance on the auditory attention task. Each stimulant produced a differential pattern of increases and decreases in regional metabolism throughout the regions of interest that were sampled. Rather than increasing glucose utilization in specific brain regions with lowered metabolic rates in adults with ADHD, stimulants may act by altering glucose use throughout the brain.

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Crossref · 10.1038/npp.1993.38

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Metadata

Authors
Matochik, J. A., Nordahl, T. E., Gross, M., Semple, W. E., King, A. C., Cohen, R. M., & Zametkin, A. J.
Affiliations
National Institutes of Health (US)
ORCID
Nordahl, Thomas E.
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1993-06
Volume
8
Issue
4
Pages
377-386
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/npp.1993.38
OpenAlex
W2076168139
Cited by
105
References
26
Citations by year
2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
4.12
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
attention deficit hyperactivity disorder, adult ADHD, stimulant medication, d-amphetamine, methylphenidate, brain glucose metabolism, regional brain metabolism, auditory attention, blood pressure
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Behavior, Brain, Dextroamphetamine, Female, Humans, Male, Methylphenidate, Middle Aged, Task Performance and Analysis, Tomography, Emission-Computed

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