Temporal Lobe Atrophy and White Matter Lesions are Related to Major Depression over 5 years in the Elderly
Open accessAbstract
The influence of organic brain changes on the development of depression in the elderly is uncertain. Cross-sectional studies, most often from clinical samples, report associations with brain atrophy and cerebrovascular disease, while longitudinal population studies have given mixed results. Our aim was to investigate whether cortical atrophy and white matter lesions (WMLs) on computed tomography (CT) predict occurrence of depression in the elderly. This is a prospective population-based study with 5-year follow-up. The baseline sample included 525 elderly subjects, aged 70-86 years, without dementia or major depression, with a score on the Mini-Mental State Examination above 25, and without dementia at follow-up. Cortical atrophy and WMLs were evaluated at baseline using CT. The main outcome measure was development of major or minor depression at follow-up according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition, as evaluated using neuropsychiatric examinations and hospital discharge registers. Logistic regression was used to estimate risk. Over the period of 5 years, 20 individuals developed major and 63 minor depression. Presence of temporal lobe atrophy (odds ratio (OR)=2.81, 95% confidence interval (CI) 1.04-7.62) and moderate-to-severe WMLs (OR=3.21, 95% CI 1.00-10.26) independently predicted major, but not minor, depression after controlling for various confounders. Other brain changes did not predict occurrence of depression. Our findings suggest that temporal lobe atrophy and WMLs represent relatively independent and complementary pathways to major depression in the elderly. This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors.
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Presence of temporal lobe atrophy and moderate-to-severe white matter lesions can predict occurrence of major depression during a 5-year followup in a population-based sample of elderly.
“Presence of temporal lobe atrophy and moderate-to-severe white matter lesions can predict occurrence of major depression during a 5-year followup in a population-based sample of elderly [62].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [62]
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Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
- Authors
- Olesen, P. J., Gustafson, D. R., Simoni, M., Pantoni, L., Östling, S., Guo, X., & Skoog, I.
- Affiliations
- University of Gothenburg (SE)
- University of Florence (IT)
- Corresponding author
- Olesen, Pernille J
- Venue
- Neuropsychopharmacology
- Published
- 2010-09-29
- Volume
- 35
- Issue
- 13
- Pages
- 2638-2645
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055580
- OpenAlex
- W2052149529
- Cited by
- 42
- References
- 50
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Florence Research (University of Florence) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Alzheimer's Association (2008-1229, ZEN‐01‐3151, IIRG‐00‐2159)
- European Commission (211696)
- Forskningsrådet för Arbetsliv och Socialvetenskap (2006‐1506, 2006-0596, ZEN-01-3151, 2006-0020, 2008-1229, 2004-0150, IIRG-00-2159, 2001-2835, 2008-1111)
- Fredrik och Ingrid Thurings Stiftelse
- Vetenskapsrådet (2007–7,462, 11267, 825–2007–7462)
- Riksbankens Jubileumsfond
- Göteborgs Universitet
- Swedish Brain Power (11267)
- National Institutes of Health (5r03ag026098-02)
- National Institute on Aging (5R03AG026098)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- temporal lobe atrophy, white matter lesions, major depressive disorder, older adults, cortical atrophy, cerebrovascular disease, neurodegeneration, depression risk prediction, neuroimaging, depression prevention
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Nerve Fibers, Myelinated, Prospective Studies, Temporal Lobe, Time Factors, Tomography, X-Ray Computed
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