Impact of Lipid Raft Integrity on 5-HT3 Receptor Function and its Modulation by Antidepressants
Open accessAbstract
Because of the biochemical colocalization of the 5-HT(3) receptor and antidepressants within raft-like domains and their antagonistic effects at this ligand-gated ion channel, we investigated the impact of lipid raft integrity for 5-HT(3) receptor function and its modulation by antidepressants. Treatment with methyl-beta-cyclodextrine (MbetaCD) markedly reduced membrane cholesterol levels and caused a more diffuse membrane distribution of the lipid raft marker protein flotillin-1 indicating lipid raft impairment. Both amplitude and charge of serotonin evoked cation currents were diminished following cholesterol depletion by either MbetaCD or simvastatin (Sim), whereas the functional antagonistic properties of the antidepressants desipramine (DMI) and fluoxetine (Fluox) at the 5-HT(3) receptor were retained. Although both the 5-HT(3) receptor and flotillin-1 were predominantly found in raft-like domains in western blots following sucrose density gradient centrifugation, immunocytochemistry revealed only a coincidental degree of colocalization of these two proteins. These findings and the persistence of the antagonistic effects of DMI and Fluox against 5-HT(3) receptors after lipid raft impairment indicate that their modulatory effects are likely mediated through non-raft 5-HT(3) receptors, which are not sufficiently detected by means of sucrose density gradient centrifugation. In conclusion, lipid raft integrity appears to be important for 5-HT(3) receptor function in general, whereas it is not a prerequisite for the antagonistic properties of antidepressants such as DMI and Fluox at this ligand-gated ion channel.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One potential mechanism by which sertraline may cause PKA activation is by liberating G-protein alpha(s) subunits from membrane-associated lipid rafts.
“One potential mechanism by which sertraline may cause this PKA activation is by liberating G-protein alpha(s) subunits from membrane-associated lipid rafts.70, 71, 72, 73”
From Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor (2011) · cites this paper as [72]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989 · see citing works
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921 · see citing works
Song, K. S., Li, S. C., Okamoto, T., Quilliam, L. A., Sargiacomo, M., & Lisanti, M. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9690 · Cited by 1,000 · see citing works
Cellular Cholesterol Efflux Mediated by Cyclodextrins
Kilsdonk, E. P. C., Yancey, P. G., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., & Rothblat, G. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17250 · Cited by 890 · see citing works
Lipid raft microdomains and neurotransmitter signalling
Allen, J., Halverson-Tamboli, R. A., & Rasenick, M. M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2059 · Cited by 850 · see citing works
Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors
Foster, L. J., de Hoog, C. L., & Mann, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0631608100 · Cited by 834 · see citing works
Molecular biology of 5-HT receptors
Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815 · see citing works
Use of cyclodextrins for manipulating cellular cholesterol content
Christian, A. E., Haynes, M. P., Phillips, M. C., & Rothblat, G. H. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34940-3 · Cited by 755 · see citing works
A detergent-free method for purifying caveolae membrane from tissue culture cells.
Smart, E. J., Ying, Y. S., Mineo, C., & Anderson, R. G. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10104 · Cited by 728 · see citing works
Lipid rafts: heterogeneity on the high seas
PIKE, L. J. (2004) · Biochemical Journal · doi:10.1042/bj20031672 · Cited by 705 · see citing works
Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability
Hering, H., Lin, C.-C., & Sheng, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03262.2003 · Cited by 602 · see citing works
Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking
Mayor, S., Rothberg, K. G., & Maxfield, F. R. (1994) · Science · doi:10.1126/science.7516582 · Cited by 513 · see citing works
PIKE, L. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800040-jlr200 · Cited by 498 · see citing works
Cellular Cholesterol Efflux Mediated by Cyclodextrins
Yancey, P. G., Rodrigueza, W. V., Kilsdonk, E. P. C., Stoudt, G. W., Johnson, W. J., Phillips, M. C., & Rothblat, G. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16026 · Cited by 458 · see citing works
Lipid rafts in neuronal signaling and function.
Tsui-Pierchala, B. A., Encinas, M., Milbrandt, J., & Johnson, E. M. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02215-4 · Cited by 420 · see citing works
London, E. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.09.002 · Cited by 258 · see citing works
Pucadyil, T. J., & Chattopadhyay, A. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.03.010 · Cited by 249 · see citing works
Toward understanding the dynamics of membrane-raft-based molecular interactions
Kusumi, A., & Suzuki, K. G. N. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.10.001 · Cited by 228 · see citing works
Human brain fluoxetine concentrations
Karson, C. N., Newton, J. E. O., Livingston, R. H., Jolly, J., Cooper, T. B., Sprigg, J., & Komoroski, R. A. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.3.322 · Cited by 201 · see citing works
Sooksawate, T., & Simmonds, M. A. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00159-3 · Cited by 153 · see citing works
Simvastatin Reduces the Association of NMDA Receptors to Lipid Rafts
Ponce, J., de la Ossa, N. P., Hurtado, O., Millán, M., Arenillas, J. F., Dávalos, A., & Gasull, T. (2008) · Stroke · doi:10.1161/strokeaha.107.498923 · Cited by 143 · see citing works
Liu, M., Huang, W., Wu, D., & Priestley, J. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04889.x · Cited by 132 · see citing works
Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor
Eisensamer, B., Rammes, G., Gimpl, G., Shapa, M., Ferrari, U., Hapfelmeier, G., Bondy, B., Parsons, C. G., Gilling, K. E., Zieglgänsberger, W., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001314 · Cited by 121 · see citing works
Self-citationHussy, N., Lukas, W., & JONES, K. A. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020441 · Cited by 101 · see citing works
Cholesterol effects on nicotinic acetylcholine receptor
Barrantes, F. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04719.x · Cited by 99 · see citing works
5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story?
van Hooft, J. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01662-3 · Cited by 93 · see citing works
Visualization of Detergent Solubilization of Membranes: Implications for the Isolation of Rafts
Garner, A. E., Smith, D. A., & Hooper, N. M. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.114108 · Cited by 92 · see citing works
Lankiewicz, S., Lobitz, N., Wetzel, C. H., Rupprecht, R., Gisselmann, G., & Hatt, H. H. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.2.202 · Cited by 90 · see citing works
Self-citationAntidepressants and Antipsychotic Drugs Colocalize with 5-HT3Receptors in Raft-Like Domains
Eisensamer, B., Uhr, M., Meyr, S., Gimpl, G., Deiml, T., Rammes, G., Lambert, J. J., Zieglgänsberger, W., Holsboer, F., & Rupprecht, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2460-05.2005 · Cited by 86 · see citing works
Self-citationDonati, R. J., Dwivedi, Y., Roberts, R. C., Conley, R. R., Pandey, G. N., & Rasenick, M. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5713-07.2008 · Cited by 84 · see citing works
Sooksawate, T., & Simmonds, M. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704360 · Cited by 67 · see citing works
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT7(a) receptors
Sjögren, B., Hamblin, M. W., & Svenningsson, P. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.069 · Cited by 66 · see citing works
Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner
Rammes, G., Eisensamer, B., Ferrari, U., Shapa, M., Gimpl, G., Gilling, K. E., Parsons, C. G., Riering, K., Hapfelmeier, G., Bondy, B., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001490 · Cited by 65 · see citing works
Self-citationDesperately seeking subunits: are native 5-HT3 receptors really homomeric complexes?
Fletcher, S., & Barnes, N. M. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01210-3 · Cited by 65 · see citing works
Donati, R. J., & Rasenick, M. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300697 · Cited by 64 · see citing works
Breitinger, H., Geetha, N., & Hess, G. P. (2001) · Biochemistry · doi:10.1021/bi0106890 · Cited by 58 · see citing works
Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells
Bari, M., Oddi, S., Simone, C. D., Spagnolo, P., Gasperi, V., Battista, N., Centonze, D., & Maccarrone, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.030 · Cited by 54 · see citing works
Kim, K., Kim, S., Choo, H. J., Kim, J., & Ko, Y. (2004) · PROTEOMICS · doi:10.1002/pmic.200401001 · Cited by 37 · see citing works
Fan, P. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90185-6 · Cited by 35 · see citing works
Detection of human and rodent 5-HT3Breceptor subunits by anti-peptide polyclonal antibodies
Reeves, D. C., & Lummis, S. C. R. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-27 · Cited by 30 · see citing works
Molina, H., Azócar, L., Ananthanarayanan, M., Arrese, M. A., & Miquel, J. F. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.01.020 · Cited by 30 · see citing works
The ins and outs of lipid domain proteomics
Sprenger, R. R., & Horrevoets, A. J. G. (2007) · PROTEOMICS · doi:10.1002/pmic.200700189 · Cited by 20 · see citing works
Baumann, P., Gaillard, J. M., Perey, M., Justafr�, J. C., & Le, P. (1983) · Journal of Neural Transmission · doi:10.1007/bf01243270 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435 · see citing works
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
Liu, J. J., Green, P., Mann, J. J., Rapoport, S. I., & Sublette, M. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.059 · Cited by 234 · see citing works
5-HT3 receptors: Role in disease and target of drugs
Walstab, J., Rappold, G., & Niesler, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.001 · Cited by 203 · see citing works
Statins and the Brain: More than Lipid Lowering Agents?
Fracassi, A., Marangoni, M., Rosso, P., Pallottini, V., Fioramonti, M., Siteni, S., & Segatto, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170703101816 · Cited by 116 · see citing works
Zschocke, J., Zimmermann, N., Berning, B., Ganal, V., Holsboer, F., & Rein, T. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.57 · Cited by 102 · see citing works
Self-citationNon-pharmacological factors that determine drug use and addiction
Ahmed, S. H., Badiani, A., Miczek, K. A., & Müller, C. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.015 · Cited by 82 · see citing works
Role of 5-HT3 Receptors in the Antidepressant Response
Betry, C., Etiévant, A., Oosterhof, C. A., Ebert, B., Sánchez, C., & Haddjeri, N. (2011) · Pharmaceuticals · doi:10.3390/ph4040603 · Cited by 76 · see citing works
Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers
Zhang, Y., Dijkman, P. M., Zou, R., Zandl‐Lang, M., Sánchez, R. M., Eckhardt-Strelau, L., Köfeler, H. C., Vogel, H., Yuan, S., & Kudryashev, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21016-7 · Cited by 69 · see citing works
Sphingolipid control of cognitive functions in health and disease
Kalinichenko, L. S., Gulbins, E., Kornhuber, J., & Müller, C. P. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101162 · Cited by 64 · see citing works
Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges
Sarkar, P., Mozumder, S., Bej, A., Mukherjee, S., Sengupta, J., & Chattopadhyay, A. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00772-8 · Cited by 67 · see citing works
A sphingolipid mechanism for behavioral extinction
Huston, J. P., Kornhuber, J., Mühle, C., Japtok, L., Komorowski, M., Mattern, C., Reichel, M., Gulbins, E., Kleuser, B., Topic, B., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13537 · Cited by 59 · see citing works
Tuccori, M., Montagnani, S., Mantarro, S., Capogrosso-Sansone, A., Ruggiero, E., Saporiti, A., Antonioli, L., Fornai, M., & Blandizzi, C. (2014) · CNS Drugs · doi:10.1007/s40263-013-0135-1 · Cited by 58 · see citing works
How lipids may affect risk for suicidal behavior
Daray, F. M., Mann, J. J., & Sublette, M. E. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.06.007 · Cited by 54 · see citing works
Scala, C. D., Fantini, J., Yahi, N., Barrantes, F. J., & Chahinian, H. (2018) · Biomolecules · doi:10.3390/biom8020031 · Cited by 52 · see citing works
Roy, A., & Patra, S. K. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10448-3 · Cited by 50 · see citing works
Liu, J. J., Hezghia, A., Shaikh, S. R., Ceñido, J. F., Stark, R. E., Mann, J. J., & Sublette, M. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0133-6 · Cited by 50 · see citing works
Allosteric modulation of the 5-HT3 receptor
Davies, P. A. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.01.010 · Cited by 47 · see citing works
Kalinichenko, L. S., Mühle, C., Jia, T., Anderheiden, F., Datz, M., Eberle, A.-L., Eulenburg, V., Granzow, J., Hofer, M., Hohenschild, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01304-w · Cited by 43 · see citing works
Müller, C. P. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112672 · Cited by 43 · see citing works
Nothdurfter, C., Tanasic, S., Benedetto, B. D., Uhr, M., Wagner, E.-M., Gilling, K. E., Parsons, C. G., Rein, T., Holsboer, F., Rupprecht, R., et al. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571200140x · Cited by 39 · see citing works
Self-citationSerotonin Signaling through Lipid Membranes
Kalinichenko, L. S., Kornhuber, J., Sinning, S., Haase, J. K., & Müller, C. P. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00823 · Cited by 37 · see citing works
Papke, D. J., & Grosman, C. F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5105-13.2014 · Cited by 34 · see citing works
Structural basis for the modulation of pentameric ligand-gated ion channel function by lipids
Thompson, M. J., & Baenziger, J. E. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183304 · Cited by 32 · see citing works
de Juan‐Sanz, J., Núñez, E., Zafra, F., Berrocal, M., Corbacho‐Cuello, I., Ibáñez, I., Arribas-González, E., Marcos, D., López‐Corcuera, B., Mata, A. M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586966 · Cited by 30 · see citing works
Cannabinoids—Multifunctional Compounds, Applications and Challenges—Mini Review
Duczmal, D., Bazan‐Wozniak, A., Niedzielska, K., & Pietrzak, R. (2024) · Molecules · doi:10.3390/molecules29204923 · Cited by 33 · see citing works
Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
Irving, H. R., Turek, I., Kettle, C., & Yaakob, N. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111910 · Cited by 30 · see citing works
He, J., Liu, R., Peng, Y.-M., Guo, Q., Zhu, L.-B., Lian, Y.-Z., Hu, B., Fan, H.-H., Zhang, X., & Zhu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02097-z · Cited by 28 · see citing works
The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Giorgi, R. D., Pesci, N. R., Rosso, G., Maina, G., Cowen, P. J., & Harmer, C. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02533-z · Cited by 29 · see citing works
Pristerà, A., & Okuse, K. (2011) · The Neuroscientist · doi:10.1177/1073858410393977 · Cited by 26 · see citing works
Fernández‐Pastor, B., Ortega, J. E., & Meana, J. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3112-y · Cited by 17 · see citing works
Bharambe, N. G., Li, Z., Seiferth, D., Balakrishna, A. M., Biggin, P. C., & Basak, S. (2024) · Nature Communications · doi:10.1038/s41467-024-47370-w · Cited by 16 · see citing works
Mechanisms of General Anesthesia
Hansen, S. B. (2025) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030222-121430 · Cited by 15 · see citing works
Cholesterol in myasthenia gravis
Paz, M. L., & Barrantes, F. J. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108788 · Cited by 11 · see citing works
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
Giorgi, R. D., Cowen, P. J., & Harmer, C. J. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2113369 · Cited by 9 · see citing works
Wray, N. H., & Rasenick, M. M. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.001 · Cited by 8 · see citing works
Morin, E. E., Salbato, S., Walker, B. R., & Naik, J. S. (2022) · Microcirculation · doi:10.1111/micc.12774 · Cited by 7 · see citing works
Sphingolipids in Emotional Well‐Being
Kalinichenko, L. S., Zoicas, I., Muehle, C., Kornhuber, J., & Müller, C. P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70379 · Cited by 3 · see citing works
Ye, Z., Wu, C.-Y., Zhang, H., Zhang, H.-W., & Vogel, H. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01763-3 · Cited by 3 · see citing works
Serotonin – lipid interactions and their role in behavior
Kalinichenko, L. S., Gulbins, E., Kornhuber, J., & Müller, C. P. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00016-5 · Cited by 3 · see citing works
He, J.-H., Liu, R.-P., Peng, Y.-M., Guo, Q., 朱兰兵, Lian, Y.-Z., Hu, B.-L., Fan, H.-H., Zhang, X., & Zhu, J.-H. (2021) · Figshare · doi:10.6084/m9.figshare.14060144
He, J.-H., Liu, R.-P., Peng, Y.-M., Guo, Q., 朱兰兵, Lian, Y.-Z., Hu, B.-L., Fan, H.-H., Zhang, X., & Zhu, J.-H. (2021) · Figshare · doi:10.6084/m9.figshare.14059665
Influence of Lipid Composition on Nonspecific Interactions of Serotonin with Model Membranes
Gudyka, J., Vega, J. C., Said, J., Silverberg, S., Rabadi, A., Ceja, J., Perla, W., Poust, C., Andersen, E., Mitchell, J., et al. (2026) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00767
- Authors
- Nothdurfter, C., Tanasic, S., Di Benedetto, B., Rammes, G., Wagner, E.-M., Kirmeier, T., Ganal, V., Kessler, J. S., Rein, T., Holsboer, F., & Rupprecht, R.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Rupprecht, Rainer
- Venue
- Neuropsychopharmacology
- Published
- 2010-03-03
- Volume
- 35
- Issue
- 7
- Pages
- 1510-1519
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055465
- OpenAlex
- W1993312736
- Cited by
- 43
- References
- 45
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 5-HT3 receptor, lipid rafts, membrane cholesterol, antidepressants, desipramine, fluoxetine, flotillin-1, simvastatin, ligand-gated ion channels, receptor antagonism, protein colocalization
- MeSH terms
- Animals, Anticholesteremic Agents, Antidepressive Agents, Biophysics, Cholesterol, Desipramine, Dose-Response Relationship, Drug, Drug Interactions, Electric Stimulation, Fluoxetine, Humans, Imidazoles, Membrane Potentials, Neuroblastoma, Serotonin, Sulfhydryl Compounds, Time Factors, Transfection, Patch-Clamp Techniques, Simvastatin, Membrane Microdomains, Receptors, Serotonin, 5-HT3, beta-Cyclodextrins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
