Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gsα Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase

The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description

Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works

The cerebellar cognitive affective syndrome

Schmahmann, J. (1998) · Brain · doi:10.1093/brain/121.4.561 · Cited by 3,230 · see citing works

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

Brown, D. A., & London, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000005200 · Cited by 2,344 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works

Disorders of the Cerebellum: Ataxia, Dysmetria of Thought, and the Cerebellar Cognitive Affective Syndrome

Schmahmann, J. D. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.3.367 · Cited by 1,442 · see citing works

The role of corticotropin-releasing factor in depression and anxiety disorders

Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works

An Emerging Concept

Schmahmann, J. D. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530230086029 · Cited by 1,030 · see citing works

Lipid raft microdomains and neurotransmitter signalling

Allen, J., Halverson-Tamboli, R. A., & Rasenick, M. M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2059 · Cited by 850 · see citing works

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

Li, S. C., Okamoto, T., Chun, M., Sargiacomo, M., Casanova, J. E., Hansen, S. H., Nishimoto, I., & Lisanti, M. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15693 · Cited by 608 · see citing works

Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae

Rybin, V. O., Xu, X., Lisanti, M. P., & Steinberg, S. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006951200 · Cited by 518 · see citing works

cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment

Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 507 · see citing works

Lipid-dependent Targeting of G Proteins into Rafts

Moffett, S., Brown, D. A., & Linder, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.2191 · Cited by 428 · see citing works

The evolving role of lipid rafts and caveolae in G protein‐coupled receptor signaling: implications for molecular pharmacology

Ostrom, R. S., & Insel, P. A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705930 · Cited by 398 · see citing works

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

Oh, P., & Schnitzer, J. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.685 · Cited by 376 · see citing works

The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins

Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12102-a · Cited by 342 · see citing works

Regional cerebral glucose utilization in patients with a range of severities of unipolar depression

Kimbrell, T. A., Ketter, T. A., George, M. S., Little, J. T., Benson, B. E., Willis, M. W., Herscovitch, P., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01216-1 · Cited by 300 · see citing works

Positron emission tomography imaging in depression: a neural systems perspective

Mayberg, H. S. (2003) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(03)00104-7 · Cited by 255 · see citing works

Platelet serotonin-2 receptor binding sites in depression and suicide

Pandey, G. N., Pandey, S. C., Janicak, P. G., Marks, R., & Davis, J. M. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90576-n · Cited by 212 · see citing works

The Role of Corticotropin‐Releasing Factor in the Pathophysiology of Affective and Anxiety Disorders: Laboratory and Clinical Studies

Owens, M. J., & Nemeroff, C. B. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch15 · Cited by 181 · see citing works

Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiesterase 4A and 4B Isoforms

Takahashi, M., Terwilliger, R. Z., Lane, C. L., Mézeš, P., Conti, M., & Duman, R. S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00610.1999 · Cited by 177 · see citing works

Caveolin-1 Interacts with 5-HT2A Serotonin Receptors and Profoundly Modulates the Signaling of Selected Gαq-coupled Protein Receptors

Bhatnagar, A., Sheffler, D. J., Kroeze, W. K., Compton-Toth, B. A., & Roth, B. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404673200 · Cited by 171 · see citing works

Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment

Menkes, D. B., Rasenick, M. M., Wheeler, M. A., & Bitensky, M. W. (1983) · Science · doi:10.1126/science.6849117 · Cited by 144 · see citing works

New vistas in neuropeptide research in neuropsychiatry: focus on corticotropin-releasing factor.

Nemeroff, C. B. (1992) · PubMed · Cited by 136 · see citing works

Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims.

Cowburn, R., Marcusson, J., Eriksson, A., Wiehager, B., & O'Neill, C. (1994) · Brain Research · doi:10.1016/0006-8993(94)91552-0 · Cited by 129 · see citing works

Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor

Eisensamer, B., Rammes, G., Gimpl, G., Shapa, M., Ferrari, U., Hapfelmeier, G., Bondy, B., Parsons, C. G., Gilling, K. E., Zieglgänsberger, W., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001314 · Cited by 121 · see citing works

Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain

Pacheco, M. A., Stockmeier, C. A., Meltzer, H. Y., Overholser, J. C., Dilley, G. E., & Jope, R. S. (1996) · Brain Research · doi:10.1016/0006-8993(96)00207-7 · Cited by 118 · see citing works

Chronic Electroconvulsive Treatment Augments Coupling of the GTP‐Binding Protein Gs to the Catalytic Moiety of Adenylyl Cyclase in a Manner Similar to That Seen with Chronic Antidepressant Drugs

Ozawa, H., & Rasenick, M. M. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02599.x · Cited by 111 · see citing works

β-Adrenergic Receptor Stimulation Promotes Gαs Internalization through Lipid Rafts: A Study in Living Cells

Allen, J., Yu, J. Z., Donati, R. J., & Rasenick, M. M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008342 · Cited by 110 · see citing works

G Protein‐Coupled Cyclic AMP Signaling in Postmortem Brain of Subjects with Mood Disorders

Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., Reiach, J. S., & Young, L. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731121.x · Cited by 104 · see citing works

cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment

Pérez, J., Tinelli, D., Brunello, N., & Racagni, G. (1989) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(89)90060-6 · Cited by 103 · see citing works

The Danish PET/depression project: PET findings in patients with major depression

Videbech, P., Ravnkilde, B., PEDERSEN, A. R., Egander, A., LANDBO, B., Rasmussen, N. A., Andersen, F. L., Stødkilde‐Jørgensen, H., GJEDDE, A. H., & ROSENBERG, R. (2001) · Psychological Medicine · doi:10.1017/s0033291701004469 · Cited by 100 · see citing works

G protein signaling and the molecular basis of antidepressant action

Donati, R. J., & Rasenick, M. M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00249-2 · Cited by 97 · see citing works

Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase is enhanced subsequent to chronic antidepressant treatment.

Ozawa, H., & Rasenick, M. M. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09657-9 · Cited by 87 · see citing works

Protein kinase a in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits

Dwivedi, Y., Rizavi, H. S., Shukla, P. K., Lyons, J., Faludi, G., Palkovits, M., Sárosi, A., Conley, R. R., Roberts, R. C., Tamminga, C. A., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.003 · Cited by 86 · see citing works

Antidepressants and Antipsychotic Drugs Colocalize with 5-HT3Receptors in Raft-Like Domains

Eisensamer, B., Uhr, M., Meyr, S., Gimpl, G., Deiml, T., Rammes, G., Lambert, J. J., Zieglgänsberger, W., Holsboer, F., & Rupprecht, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2460-05.2005 · Cited by 86 · see citing works

α2-Adrenoceptor—Mediated Inhibition of Platelet Adenylate Cyclase and Induction of Aggregation in Major Depression

Garcı́a-Sevilla, J. A. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140025005 · Cited by 74 · see citing works

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein (GS) and Adenylyl Cyclase

Jiang, C., & Rasenick, M. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020724.x · Cited by 71 · see citing works

cAMP binding proteins in the rat cerebral cortex after administration of selective 5-HT and NE reuptake blockers with antidepressant activity.

Pérez, J., Tinelli, D., Bianchi, E., Brunello, N., & Racagni, G. (1991) · PubMed · Cited by 69 · see citing works

Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression

Davies, J., Lloyd, K. R., Jones, I. K., Barnes, A., & Pilowsky, L. S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.374 · Cited by 65 · see citing works

Platelet Adenylyl Cyclase Activity: A Biological Marker for Major Depression and Recent Drug Use

Hines, L. M., & Tabakoff, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.040 · Cited by 64 · see citing works

Chronic Antidepressant Treatment Prevents Accumulation of Gsα in Cholesterol-Rich, Cytoskeletal-Associated, Plasma Membrane Domains (Lipid Rafts)

Donati, R. J., & Rasenick, M. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300697 · Cited by 64 · see citing works

Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium

Stewart, R. J., Chen, B., Dowlatshahi, D. D., MacQUEEN, G. M., & Young, L. T. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00524-x · Cited by 63 · see citing works

mRNA and Protein Expression of Selective Alpha Subunits of G Proteins are Abnormal in Prefrontal Cortex of Suicide Victims

Dwivedi, Y. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00335-4 · Cited by 55 · see citing works

Treatment of C6 Glioma Cells and Rats with Antidepressant Drugs Increases the Detergent Extraction of Gsα from Plasma Membrane

Toki, S., Donati, R. J., & Rasenick, M. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731114.x · Cited by 54 · see citing works

Corticotropin-releasing factor type-1 receptor antagonists: The next class of antidepressants?

Nielsen, D. M. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.06.003 · Cited by 49 · see citing works

Brain Region Specific Alterations in the Protein and mRNA Levels of Protein Kinase A Subunits in the Post-Mortem Brain of Teenage Suicide Victims

Pandey, G. N., Dwivedi, Y., Ren, X., Rizavi, H. S., Mondal, A. C., Shukla, P. K., & Conley, R. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300765 · Cited by 45 · see citing works

Alterations in Detergent Solubility of Heterotrimeric G Proteins after Chronic Activation of Gi/o-Coupled Receptors: Changes in Detergent Solubility Are in Correlation with Onset of Adenylyl Cyclase Superactivation

Bayewitch, M. L., Nevo, I., Avidor‐Reiss, T., Levy, R., Simonds, W. F., & Vogel, Z. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.4.820 · Cited by 45 · see citing works

Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression

Menninger, J. A., & Tabakoff, B. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00245-4 · Cited by 44 · see citing works

Antidepressant interactions with corticotropin-releasing factor in the noradrenergic nucleus locus coeruleus.

Valentino, R. J., & Curtis, A. L. (1991) · PubMed · Cited by 38 · see citing works

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gsα

Donati, R. J., Thukral, C., & Rasenick, M. M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.6.1426 · Cited by 37 · see citing works

Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase

Mooney, J. J., Schatzberg, A. F., Cole, J. O., Kizuka, P. P., Salomon, M. S., Lerbinger, J. E., Pappalardo, K. M., Gerson, B., & Schildkraut, J. J. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90002-9 · Cited by 36 · see citing works

Corticotropin-releasing factor antagonists in affective disorders

Owens, M. J., & Nemeroff, C. B. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.11.1849 · Cited by 34 · see citing works

Platelet Adenylyl Cyclase Activity as a Trait Marker of Alcohol Dependence

Menninger, J. A., Barón, A. E., Conigrave, K. M., Whitfield, J. B., Saunders, J. B., Helander, A., Eriksson, C. J. P., Grant, B. F., Hoffman, P. L., & Tabakoff, B. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02060.x · Cited by 34 · see citing works

Immunohistochemical visualization of corticotropin‐releasing factor type 1 (CRF1) receptors in monkey brain

Kostich, W. A., Grzanna, R., Lu, N. Z., & Largent, B. L. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20271 · Cited by 32 · see citing works

Effect of antidepressants on neuroendocrine axis in humans.

Hy, M., Fang, V. S., Tricou, B. J., & Robertson, A. (1982) · PubMed · Cited by 31 · see citing works

Selective adenylate cyclase increase in the limbic area of long-term imipramine-treated rats

Montis, M. G. D., Devoto, P., Gessa, G. L., Porcella, A., Serra, G., & Tagliamonte, A. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90605-6 · Cited by 27 · see citing works

PERIPHERAL ADRENERGIC RECEPTORS IN AFFECTIVE ILLNESS AND SCHIZOPHRENIA

Pandey, G. N., Pandey, S. C., & Davis, J. M. (1990) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1990.tb02071.x · Cited by 22 · see citing works

Platelet Adenylyl Cyclase Activity as a State or Trait Marker in Alcohol Dependence: Results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence

Hoffman, P. L., Glanz, J. M., & Tabakoff, B. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02642.x · Cited by 20 · see citing works

Signal Transduction by Platelet Adenylate Cyclase: Alterations in Depressed Patients May Reflect Impairment in the Coordinated Integration of Cellular Signals (Coincidence Detection) 11This work was presented in part at the Annual Meeting of the American Psychiatric Association, New York, NY, May 7, 1996.

Mooney, J. J., SAMSON, J. A., McHale, N. L., Colodzin, R., Alpert, J. E., Koutsos, M., & Schildkraut, J. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00327-2 · Cited by 17 · see citing works

Alterations of Tubulin Function Caused by Chronic Antidepressant Treatment in Rat Brain

Kamada, H., Saito, T., Hatta, S., Toki, S., Ozawa, H., Watanabe, M., & Takahata, N. (1999) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006972709733 · Cited by 14 · see citing works

The GABAergic deficit hypothesis of major depressive disorder

Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435 · see citing works

Brain membrane lipids in major depression and anxiety disorders

Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works

Lipids in Psychiatric Disorders and Preventive Medicine

Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works

Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments

Kadriu, B., Musazzi, L., Henter, I. D., Graves, M., Popoli, M., & Zarate, C. A. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy094 · Cited by 165 · see citing works

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Du, J., Zhu, M. F., Bao, H., Bai, L., Dong, Y., Xiao, C., Zhang, G. Y., Henter, I. D., Rudorfer, M. V., & Vitiello, B. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.876960 · Cited by 164 · see citing works

γ-Aminobutyric Acid-Type A Receptor Deficits Cause Hypothalamic-Pituitary-Adrenal Axis Hyperactivity and Antidepressant Drug Sensitivity Reminiscent of Melancholic Forms of Depression

Shen, Q., Lal, R., Luellen, B. A., Earnheart, J. C., Andrews, A. M., & Luscher, B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.024 · Cited by 139 · see citing works

Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT1Areceptor agonist

Newman‐Tancredi, A., Martel, J.-C., Assié, M. B., Buritova, J., Lauressergues, E., Cosi, C., Heusler, P., Slot, L. A. B., Colpaert, F. C., Vacher, B., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00001.x · Cited by 128 · see citing works

NMDAR-independent, cAMP-dependent antidepressant actions of ketamine

Wray, N. H., Schappi, J. M., Singh, H., Senese, N. B., & Rasenick, M. M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0083-8 · Cited by 125 · see citing works

Metabolomic and inflammatory signatures of symptom dimensions in major depression

Brydges, C. R., Bhattacharyya, S., Dehkordi, S. M., Milaneschi, Y., Penninx, B., Jansen, R., Kristal, B. S., Han, X., Arnold, M., Kastenmüller, G., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.02.003 · Cited by 108 · see citing works

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Zhong, H., Haddjeri, N., & Sánchez, C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2463-5 · Cited by 105 · see citing works

Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling

Allen, J., Yu, J. Z., Davé, R. H., Bhatnagar, A., Roth, B. L., & Rasenick, M. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.060160 · Cited by 83 · see citing works

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders

Morris, G., Walder, K. R., Puri, B. K., Berk, M., & Maes, M. H. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9392-y · Cited by 69 · see citing works

Cells, biomarkers, and post‐traumatic stress disorder: evidence for peripheral involvement in a central disease

Andrews, J. A., & Neises, K. D. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07545.x · Cited by 66 · see citing works

Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G Protein, Gαs

Erb, S. J., Schappi, J. M., & Rasenick, M. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.727263 · Cited by 64 · see citing works

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

Allen, J., Yadav, P. N., & Roth, B. L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.048 · Cited by 59 · see citing works

Regulation of monoamine transporters and receptors by lipid microdomains: implications for depression

Liu, J. J., Hezghia, A., Shaikh, S. R., Ceñido, J. F., Stark, R. E., Mann, J. J., & Sublette, M. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0133-6 · Cited by 50 · see citing works

Impact of Lipid Raft Integrity on 5-HT3 Receptor Function and its Modulation by Antidepressants

Nothdurfter, C., Tanasic, S., Di Benedetto, B., Rammes, G., Wagner, E.-M., Kirmeier, T., Ganal, V., Kessler, J. S., Rein, T., Holsboer, F., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.20 · Cited by 43 · see citing works

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders

Senese, N. B., Rasenick, M. M., & Traynor, J. R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01289 · Cited by 41 · see citing works

Chronic Treatment with Escitalopram but Not R-Citalopram Translocates Gαs from Lipid Raft Domains and Potentiates Adenylyl Cyclase: A 5-Hydroxytryptamine Transporter-Independent Action of This Antidepressant Compound

Zhang, L., & Rasenick, M. M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162644 · Cited by 42 · see citing works

α2-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims

Valdizán, E. M., Dı́ez-Alarcia, R., González‐Maeso, J., Pilar-Cuéllar, F., Garcı́a-Sevilla, J. A., Meana, J. J., & Pazos, Á. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.023 · Cited by 41 · see citing works

G-Protein Signaling, Lipid Rafts and the Possible Sites of Action for the Antidepressant Effects of n-3 Polyunsaturated Fatty Acids

Czysz, A. H., & Rasenick, M. M. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312040005 · Cited by 39 · see citing works

Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

Nothdurfter, C., Tanasic, S., Benedetto, B. D., Uhr, M., Wagner, E.-M., Gilling, K. E., Parsons, C. G., Rein, T., Holsboer, F., Rupprecht, R., et al. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571200140x · Cited by 39 · see citing works

Can targeted metabolomics predict depression recovery? Results from the CO-MED trial

Czysz, A. H., South, C. C., Gadad, B. S., Arning, E., Soyombo, A. A., Bottiglieri, T., & Trivedi, M. H. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0349-6 · Cited by 38 · see citing works

A novel peripheral biomarker for depression and antidepressant response

Targum, S. D., Schappi, J. M., Koutsouris, A., Bhaumik, R., Rapaport, M. H., Rasgon, N., & Rasenick, M. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01399-1 · Cited by 38 · see citing works

Cholesterol, GM1, and Autism

Schengrund, C., Ali-Rahmani, F. G., & Ramer, J. C. (2012) · Neurochemical Research · doi:10.1007/s11064-011-0697-6 · Cited by 36 · see citing works

Bio Molecular Considerations in Major Depression and Ischemic Cardiovascular Disease

Cocchi, M., & Tonello, L. (2010) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152410791196378 · Cited by 33 · see citing works

Fish oil and depression: The skinny on fats

Burhani, M. D., & Rasenick, M. M. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170072 · Cited by 32 · see citing works

SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling

Ha, C. M., Park, D., Kim, Y., Na, M., Panda, S., Won, S., Kim, H., Ryu, H., Park, Z., Rasenick, M. M., et al. (2015) · Journal of Cell Science · doi:10.1242/jcs.169581 · Cited by 32 · see citing works

Modulation of Monoamine Receptors by Adaptor Proteins and Lipid Rafts: Role in Some Effects of Centrally Acting Drugs and Therapeutic Agents

Björk, K., & Svenningsson, P. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100520 · Cited by 30 · see citing works

The Cell Membrane: Is It A Bridge From Psychiatry To Quantum Consciousness?

Tonello, L., & Cocchi, M. (2010) · NeuroQuantology · doi:10.14704/nq.2010.8.1.268 · Cited by 29 · see citing works

Membrane-Associated α-Tubulin Is Less Acetylated in Postmortem Prefrontal Cortex from Depressed Subjects Relative to Controls: Cytoskeletal Dynamics, HDAC6, and Depression

Singh, H., Chmura, J., Bhaumik, R., Pandey, G. N., & Rasenick, M. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3033-19.2020 · Cited by 28 · see citing works

Quantitative Profiling of Brain Lipid Raft Proteome in a Mouse Model of Fragile X Syndrome

Kalinowska, M., Castillo, C., & Francesconi, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121464 · Cited by 26 · see citing works

The Interactome Hypothesis of Depression

Cocchi, M., Gabrielli, F., Tonello, L., & Pregnolato, M. (2010) · NeuroQuantology · doi:10.14704/nq.2010.8.4.318 · Cited by 24 · see citing works

Extra virgin olive oil and oleic acid.

Cocchi, M., Tonello, L., Álvarez, J. R. M., Lercker, G., & Caramia, G. (2009) · Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria · Cited by 22 · see citing works

Human depression: a new approach in quantitative psychiatry

Cocchi, M., Tonello, L., & Rasenick, M. M. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-25 · Cited by 22 · see citing works

Mast Cells, Astrocytes, Arachidonic Acid: Do They Play a Role in Depression?

Traina, G., & Cocchi, M. (2020) · Applied Sciences · doi:10.3390/app10103455 · Cited by 21 · see citing works

Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism

Cocchi, M., Minuto, C., Tonello, L., Gabrielli, F., Bernroider, G., Tuszyński, J. A., Cappello, F., & Rasenick, M. M. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0356-1 · Cited by 20 · see citing works

Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression

Wang, J., Hu, X., Li, Y., Li, S., Wang, T., Wang, D., Gao, Y., Wang, Q., Zhou, J., & Wan, C. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103491 · Cited by 18 · see citing works

Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization

Donati, R. J., Schappi, J. M., Czysz, A. H., Jackson, A. R., & Rasenick, M. M. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0178-y · Cited by 18 · see citing works

Do mood disorders play a role in pig welfare?

Cocchi, M., Sardi, L., Tonello, L., & Martelli, G. (2009) · Italian Journal of Animal Science · doi:10.4081/ijas.2009.691 · Cited by 18 · see citing works

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17 · see citing works

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids

Chukaew, P., Leow, A., Saengsawang, W., & Rasenick, M. M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0724-6 · Cited by 16 · see citing works

cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission

Riggs, L. M., Pereira, E. F. R., Thompson, S. M., & Gould, T. D. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00326.2023 · Cited by 14 · see citing works

Platelet’s Fatty Acids and Differential Diagnosis of Major Depression and Bipolar Disorder through the Use of an Unsupervised Competitive-Learning Network Algorithm (SOM)

Benedetti, S., Bucciarelli, S., Canestrari, F., Catalani, S., Mandolini, S., Marconi, V., Mastrogiacomo, A. R., Silvestri, R., Tagliamonte, M. C., Venanzini, R., et al. (2014) · Open Journal of Depression · doi:10.4236/ojd.2014.32011 · Cited by 13 · see citing works

Ischemic conditions and β-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells

Brambilla, A., Lonati, E., Milani, C., Rizzo, A. M., Farina, F., Botto, L., Masserini, M., Palestini, P., & Bulbarelli, A. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.10.005 · Cited by 13 · see citing works

Major Depression and Bipolar Disorder: The Concept of Symmetry Breaking

Cocchi, M., Gabrielli, F., Pessa, E., Pregnolato, M., Tonello, L., & Zizzi, P. (2012) · NeuroQuantology · doi:10.14704/nq.2012.10.4.577 · Cited by 12 · see citing works

Running the hypothesis of a bio molecular approach to psychiatric disorder characterization and fatty acids therapeutical choices

Cocchi, M., & Tonello, L. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-s1-s26 · Cited by 12 · see citing works

Consciousness and Hallucinations: Molecular Considerations and Theoretical Questions

Cocchi, M., Tonello, L., Gabrielli, F., & Pregnolato, M. (2011) · NeuroQuantology · doi:10.14704/nq.2011.9.1.374 · Cited by 11 · see citing works

Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression

Schappi, J. M., & Rasenick, M. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1012778 · Cited by 11 · see citing works

The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts

Komatsuya, K., Kikuchi, N., Hirabayashi, T., & Kasahara, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065566 · Cited by 11 · see citing works

Antidepressants enter cells, organelles, and membranes

Blumenfeld, Z., Bera, K., Ċastrén, E., & Lester, H. A. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01725-x · Cited by 10 · see citing works

Antidepressants Produce Persistent Gαs-Associated Signaling Changes in Lipid Rafts after Drug Withdrawal

Senese, N. B., & Rasenick, M. M. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.120.000226 · Cited by 10 · see citing works

Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: An exploratory study

Mooney, J. J., SAMSON, J. A., McHale, N. L., Pappalarado, K. M., Alpert, J. E., & Schildkraut, J. J. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.005 · Cited by 10 · see citing works

Lipid rafts in psychiatry

Wray, N. H., & Rasenick, M. M. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.001 · Cited by 8 · see citing works

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Zhu, Z.-R., Tan, Z., Li, Y., Luo, H., Hu, X., Tang, M., Hescheler, J., Mu, Y., & Zhang, L. (2015) · Nutrition · doi:10.1016/j.nut.2015.02.012 · Cited by 8 · see citing works

Receptor signaling and the cell biology of synaptic transmission

Yu, J.-Z., & Rasenick, M. M. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00002-4 · Cited by 7 · see citing works

Every Detail Matters. That Is, How the Interaction between Gα Proteins and Membrane Affects Their Function

Polit, A., Mystek, P., & Błasiak, E. (2021) · Membranes · doi:10.3390/membranes11030222 · Cited by 7 · see citing works

Biological and Anthropological- Existential Hypothesis on Depression

Cocchi, M., Tonello, L., Gabrielli, F., & Pregnolato, M. (2011) · Cited by 4 · see citing works

Examining epigenetic aging in the post-mortem brain in attention deficit hyperactivity disorder

Shastri, G. G., Sudre, G. P., Ahn, K., Jung, B., Kolachana, B. S., Auluck, P. K., Elnitski, L. L., & Shaw, P. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1480761 · Cited by 4 · see citing works

A simple platelet biomarker is associated with symptom severity in major depressive disorder

Günay, A., Targum, S. D., Leow, A., Ajilore, O., & Rasenick, M. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02941-1 · Cited by 4 · see citing works

Characterization of lipid rafts in human platelets using nuclear magnetic resonance: A pilot study

Ceñido, J. F., Itin, B., Stark, R. E., Huang, Y.-Y., Oquendo, M. A., Mann, J. J., & Sublette, M. E. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2017.03.005 · Cited by 4 · see citing works

Serum Fatty Acid Latent Classes Are Associated With Suicide in a Large Military Personnel Sample

Ryan, A. T., Postolache, T. T., Taub, D. D., Wilcox, H. C., Ghahramanlou‐Holloway, M., Umhau, J. C., & Deuster, P. A. (2021) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.20m13275 · Cited by 3 · see citing works

Lipid Rafts, G Proteins and the Etiology of and Treatment for Depression: Progress toward a Depression Biomarker

Donati, R. J., & Rasenick, M. M. (2008) · Future Neurology · doi:10.2217/14796708.3.5.511 · Cited by 3 · see citing works

New insights into the molecular pathophysiology and treatment of depression

Chattaraj, B., Karmakar, S., & Jash, R. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.013 · Cited by 2 · see citing works

Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis

Mezzomo, G., Schons, T., da Rosa, P. H., Ziani, P. R., Pedroso, L. S., Rocha, G., Alves, P. P., Pulcinelli, R. R., & Rosa, A. R. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04542-9 · Cited by 2 · see citing works

The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis

Hoertel, N., Mühle, C., MÜLLER, C. P., Chaieb, H., Scheer, V., Fayad, M., Rico, M. S., Limosin, F., & Kornhuber, J. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03649-6 · Cited by 2 · see citing works

Mood Psychopathologies: An Integrated Complexity-Based Interpretation

Cocchi, M., Tonello, L., & Gabrielli, F. (2014) · Psychology · doi:10.4236/psych.2014.53030 · Cited by 2 · see citing works

The Molecular and Quantum Approach to Psychopathology and Consciousness — From Theory to Experimental Practice

Cocchi, M., Tonello, L., & Gabrielli, F. (2015) · InTech eBooks · doi:10.5772/59392 · Cited by 2 · see citing works

Serotonergic and Noradrenergic Neurotransmitter Systems in Suicide

Dwivedi, Y. (2015) · Advances in biological psychiatry · doi:10.1159/000435768 · Cited by 2 · see citing works

A dialogue on the issue of the “quantum brain” between consciousness and unconsciousness

Cocchi, M., Gabrielli, F., Tonello, L., & Tuszyński, J. A. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170062 · Cited by 2 · see citing works

Rafting toward a depression biomarker

Rasenick, M. M. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02071-3 · Cited by 1 · see citing works

Cell Membrane and Consciousness: A Journey Through Biology, Mathematics and Philosophy

Cocchi, M., Tonello, L., & Gabrielli, F. (2014) · Cited by 1 · see citing works

Stream of consciousness: Quantum and biochemical assumptions regarding psychopathology

Tonello, L., Cocchi, M., Gabrielli, F., & Tuszyński, J. A. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.013 · Cited by 2 · see citing works

Role of Membrane Microdomains in Serotonin Receptor Functions

Labus, J., Wirth, A., Zeug, A., & Ponimaskin, E. G. (2017) · Springer series in biophysics · doi:10.1007/978-3-319-66601-3_12 · Cited by 1 · see citing works

G-Protein Coupled Receptors

Saengsawang, W., Chukaew, P., & Rasenick, M. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00123-1 · Cited by 1 · see citing works

Reduced Consumption of Olive Oil: A Risk for Ischemic Heart Disease?

Cocchi, M., & Lercker, G. (2013) · InTech eBooks · doi:10.5772/54035

Biomarkers and Surrogate Markers in Drug Development

Cutler, N. R., Sramek, J. J., Murphy, M. F., Riordan, H., Bieck, P. R., & Carta, A. (2010) · Wiley eBooks · doi:10.1002/9781444318579.ch4

Receptor signaling in suicide

Dwivedi, Y. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.039

Research: Mediators and Moderators

Koslow, S. H., Ruiz, P., & Nemeroff, C. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519502.033

Minds, Membranes, Microtubules and Madness. Current Progress in QPP-Related Research.

Pregnolato, M., Pizzi, R. M. R., Cocchi, M., Tonello, L., & Rasenik, M. (2013) · doi:10.13140/2.1.2422.2726

Psychiatric Doubts

Cocchi, M., Tonello, L., & Gabrielli, F. (2014) · Open Journal of Depression · doi:10.4236/ojd.2014.31003

A heterotrimeric G protein (Gsα) biomarker may predict antidepressant response in subjects with major depressive disorder.

Targum, S. D., Günay, A., Leow, A., Ajilore, O., Rapaport, M. H., & Rasenick, M. M. (2025) · Europe PMC (PubMed Central) · doi:10.3389/fpsyt.2025.1619243

Antidepressants Accumulate in Lipid Rafts and Modify the Acylation State of G alpha S

Erb, S. J. (2015) · Figshare

Chronic Antidepressant Treatment Prevents Accumulation of Gsα in Cholesterol-Rich, Cytoskeletal-Associated, Plasma Membrane Domains (Lipid Rafts)

Donati, R. J., & Rasenick, M. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300697 · Cited by 64 · see citing works

Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gsα

Donati, R. J., Thukral, C., & Rasenick, M. M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.6.1426 · Cited by 37 · see citing works

Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G Protein, Gαs

Erb, S. J., Schappi, J. M., & Rasenick, M. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.727263 · Cited by 64 · see citing works

Transience of antidepressant‐induced Gα s signaling potentiation revealed by high‐throughput real‐time cAMP accumulation

Senese, N., & Rasenick, M. M. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.554.10