D-Cycloserine Augmentation of Exposure Therapy for Post-Traumatic Stress Disorder: A Pilot Randomized Clinical Trial
Difede, JoAnn, Cukor, Judith, Wyka, Katarzyna, Olden, Megan, Hoffman, Hunter, Lee, Francis S, Altemus, Margaret·2014·Neuropsychopharmacology
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- A transdiagnostic meta-analysis of acute augmentations to psychological therapyCamilla L. Nord, Beth F. Longley, Quentin Dercon, Veronica Phillips, Julia Funk, Siobhan Gormley, Rachel Knight, Alicia Smith, Tim Dalgleish · 2023 · Nature Mental Health
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- Trauma and PTSDJanice C. L. Lee, Fort Belvoir · 2015
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