Dynorphin, dysphoria and dependence: the stress of addiction
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Opioids, psychostimulants, and alcohol activate dynorphin, particularly in the shell of the NAc, triggered by cAMP-to-dynorphin activation.
“Another mechanism to explain the hypodopaminergic state is that opioids, psychostimulants, and alcohol activate dynorphin, particularly in the shell of the NAc, triggered by a cascade of molecular events that involve cAMP-to-dynorphin activation (Carlezon et al., 2000;Chavkin and Koob, 2016).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Chavkin and Koob, 2016
Kappa-opioid receptor agonists and dynorphins produce aversive-like effects in both animals and humans and have been hypothesized to mediate negative emotional states associated with drug withdrawal, pain, and acute withdrawal.
“k-Opioid receptor agonists (administered systemically) and dynorphins (administered intracerebrally) produce aversive-like effects in both animals and humans (Shippenberg et al., 2007) and have been hypothesized to mediate negative emotional states that are associated with drug withdrawal (Chavkin and Koob, 2016), pain, and more specifically pain that is associated with acute withdrawal (see also”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Chavkin and Koob, 2016
Cites
Addiction as a stress surfeit disorder
Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B. D. L., Tyndall, M., & Walsh, S. L. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0137-5 · Cited by 639 · see citing works
Self-citationNeurobiology of opioid addiction: Opponent process, hyperkatifeia, and negative reinforcement
Koob, G. F. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.023 · Cited by 477 · see citing works
Self-citationDrug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works
Self-citationAddiction and Stress: An Allostatic View
Koob, G. F., & Schulkin, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.008 · Cited by 315 · see citing works
Self-citationInteroception and the origin of feelings: A new synthesis
Carvalho, G. B., & Damasio, A. (2021) · BioEssays · doi:10.1002/bies.202000261 · Cited by 132 · see citing works
Allostatic mechanisms of opioid tolerance beyond desensitization and downregulation
Cahill, C. M., Walwyn, W., Taylor, A. M. W., Pradhan, A. A. A., & Evans, C. J. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.08.002 · Cited by 122 · see citing works
Nation, K. M., De Felice, M., Hernandez, P. I., Dodick, D. W., Neugebauer, V., Navratilova, E., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001167 · Cited by 96 · see citing works
Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma
Pennington, Z. T., Trott, J. M., Rajbhandari, A. K., Li, K., Walwyn, W. M., Evans, C. J., & Fanselow, M. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0559-5 · Cited by 19 · see citing works
“Chronic opioid pretreatment potentiates SEFL independent of treatment frequency and bouts of acute withdrawal The experience of acute withdrawal is frequently posited to underlie the changes in negative affective states associated with addiction [20, 21].”
Background
- Authors
- Chavkin, C., & Koob, G. F.
- Affiliations
- University of Washington (US)
- National Institutes of Health (US)
- Corresponding author
- Chavkin, Charles
- Venue
- Neuropsychopharmacology
- Published
- 2015-12-10
- Volume
- 41
- Issue
- 1
- Pages
- 373-374
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4677142
- OpenAlex
- W2193936724
- Cited by
- 149
- References
- 1
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 30 · 2020: 17 · 2019: 27 · 2018: 13 · 2017: 9 · 2016: 2
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- William K. Warren Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- dynorphin, kappa opioid receptor, prodynorphin, addiction, withdrawal, dysphoria, stress, stress resilience, drug-seeking behavior, reinstatement, anhedonia, craving, neuroplasticity
- MeSH terms
- Animals, Benzamides, Major Depressive Disorder, Depressive Disorder, Major, Dynorphins, Humans, Pyrrolidines, Stress, Psychological, Behavior, Addictive, Receptors, Opioid, kappa
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
