Addiction and stress: An allostatic view

Koob, George F.; Schulkin, Jay

doi:10.1016/j.neubiorev.2018.09.008

Cited by 315Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.

Addiction and stress: An allostatic view

Koob, George F., Schulkin, Jay·2019·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2018.09.008

Open this paper in CoChat — free account

Abstract

Allostasis, or stability through change, has most often been linked with challenges to homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to generate an allostatic state that can ultimately lead to a disease state. The present review argues that the impact of stress on drug addiction fits with an allostatic model and represents a challenge to brain circuit regulatory mechanisms that underlie the emotional state of the animal. The central thesis is that stress leads to changes in corticotropin-releasing factor in the brain that impact addiction. Stress is further argued to impact all three stages of the addiction cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-exposing the animal to an emotional allostatic load and allostatic state that forms the growing motivational pathology of addiction. Viewing addiction as an allostatic mechanism provides key insights into the ways in which dysregulated neurocircuitry that is involved in basic motivational systems can transition to pathophysiology.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2018.09.008

Cites

204 of 204 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Classically, with opioids and alcohol, individuals with a substance use disorder may start with recreational use during the binge/intoxication stage and progress to the withdrawal/negative affect stage as negative reinforcement evolves.
“Classically, with opioids and alcohol, individuals with a substance use disorder may start with recreational use of the drug during the binge/intoxication stage and progress to the withdrawal/negative affect stage as negative reinforcement evolves (Koob et al., 2019; Fig. 2).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob et al., 2019
A heuristic framework for addiction includes a three-stage cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation.
“A heuristic framework for addiction includes a threestage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the relatively new construct of hyperkatifeia in the context of drug withdrawal (Koob and Le Moal, 1997;Koob, 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob, 2019
Both somatic and psychologic symptoms of withdrawal are mediated by physiological changes in the body and brain, but symptoms associated with hyperkatifeia have significantly more motivational significance than somatic signs of withdrawal.
“However, both somatic and psychologic symptoms are mediated by physiological changes in the body and brain, but the argument here is that the symptoms that are associated with hyperkatifeia have significantly more motivational significance than somatic signs of withdrawal (Koob, 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob, 2019
In OUD, a classic pattern evolves in which the individual must administer the drug to avoid severe dysphoria and discomfort associated with abstinence.
“A classic pattern evolves in which the individual must administer the drug to avoid the severe dysphoria and discomfort that are associated with abstinence (Koob et al., 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob et al., 2019
Many individuals with AUD continue with a binge/withdrawal pattern for extended periods; for others, the pattern evolves into an opioid-like substance use disorder in which they must have alcohol available at all times to avoid consequences of abstinence.
“Many individuals with AUD continue with a binge/withdrawal pattern for extended periods; for others, the pattern evolves into an opioid-like substance use disorder, in which they must have alcohol available at all times to avoid the consequences of abstinence (Koob et al., 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob et al., 2019

The focus of between-system neuroadaptations fell on understanding neurocircuitry within the extended amygdala and its role in opponent process, more specifically hyperkatifeia.
“Subsequently, the focus of between-system neuroadaptations fell on understanding neurocircuitry within the extended amygdala and its role in opponent process, more specifically hyperkatifeia (Koob and Bloom, 1988;Koob and Le Moal, 2008;Koob, 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob, 2019
Much of the data show the recruitment of brain stress systems, including CRF, norepinephrine, hypocretin, dynorphin, and glucocorticoids, as major key substrates responsible for hyperkatifeia associated with drug withdrawal and thus compulsive-like drug seeking via negative reinforcement.
“Much of the data show the recruitment of brain stress systems, including CRF, norepinephrine, hypocretin, dynorphin, and glucocorticoids, as major key substrates that are responsible for hyperkatifeia that is associated with drug withdrawal and thus compulsivelike drug seeking via negative reinforcement (Koob and Bloom, 1988;Koob, 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob, 2019
CRF in the extended amygdala may play an important role in hyperkatifeia driving compulsive-like drug seeking for opioids and alcohol via negative reinforcement.
“Thus, CRF in the extended amygdala may play an important role in the development of hyperkatifeia that drives compulsive-like drug seeking that is associated with opioids and alcohol via a negative-reinforcement process (Koob, 2019).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Koob, 2019
Activated GR recruits CRF signaling in the CeA.
“given that activated GR recruits CRF signaling in the CeA (Koob and Schulkin, 2019;Tunstall et al., 2017)”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Koob and Schulkin, 2019
Withdrawal can produce elevated levels of GCs and increase release of CRF in the central nucleus of the amygdala.
“Withdrawal can produce elevated levels of GCs and increase release of CRF in the central nucleus of the amygdala [175].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [175]
Stress leads to changes in brain CRF that have a direct impact on addiction.
“The central thesis in Koob’s allostatic view of stress and addiction is that stress leads to changes in brain CRF that have a direct impact on addiction [175].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [175]
Behavioral economics is a conceptual system to understand how one's access and exposure predict demand and subsequent intake.
“The environment in which one resides is a known predictor of consumption behavior (39), thus behavioral economics is a conceptual system to understand how one's access and exposure will predict demand and subsequent intake (40–43).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [42]
In an ecological study of one Southern California county from 2010 to 2014 (n = 1,205), higher education and income were protective against opioid-related deaths.
“In an ecological study of one Southern California county from 2010 to 2014 (n = 1,205) higher education and income were protective against opioid-related deaths but the data suggests that no group is immune and there is dire need for public health interventions at all SES levels (42).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [42]

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,842
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Neurocircuitry of Addiction
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Self-citation
The Stress of Life
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698
Self-citation
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Self-citation
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Self-citation
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citation
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001
Allostasis and Allostatic Load Implications for Neuropsychopharmacology
McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704
Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions
Niendam, T. A., Laird, A. R., Ray, K. L., Dean, Y. M., Glahn, D. C., & Carter, C. S. (2012) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0083-5 · Cited by 1,700
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457
Self-citation
Allostasis: A New Paradigm to Explain Arousal Pathology
Sterling, P., & Eyer, J. (1988) · Zenodo · doi:10.5281/zenodo.13537700 · Cited by 1,450
Handbook of Life Stress, Cognition and Health
PASTOR, L. H. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.10.1347 · Cited by 1,402
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355
Motivation concepts in behavioral neuroscience
Berridge, K. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.004 · Cited by 1,302
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270
Alcohol and depression
Boden, J. M., & Fergusson, D. M. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03351.x · Cited by 1,233
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056
Self-citation
Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression
Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2063-07.2007 · Cited by 1,051
Addiction: Beyond dopamine reward circuitry
Volkow, N. D., Wang, G.-J., Fowler, J. S., Tomasi, D., & Telang, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010654108 · Cited by 959
The addicted human brain: insights from imaging studies
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18533 · Cited by 916
Stress dysregulation of drug reward pathways, and the transition to drug dependence
Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868
Psychotomimesis Mediated by κ Opiate Receptors
Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986) · Science · doi:10.1126/science.3016896 · Cited by 857
Behavioral Medicine: Changing- Health Lifestyles
Colvin, D. F. (1980) · Annals of Behavioral Medicine · doi:10.1093/abm/2.3.27 · Cited by 800
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703
Evidence from rats that morphine tolerance is a learned response
Siegel, S. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077058 · Cited by 657
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601
Determinants of relapse: Implications for the maintenance of behavior change.
Marlatt, G. A. (1989) · Medical Entomology and Zoology · Cited by 600
Corticosterone levels determine individual vulnerability to amphetamine self-administration.
Piazza, P. V., Maccari, S., Deminière, J.-M., Moal, M. L., Mormède, P., & Simon, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2088 · Cited by 572
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis
Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565
Self-citation
Webster’s Ninth New Collegiate Dictionary
慈继伟 (1985) · 外语教学与研究：外国语文双月刊 · Cited by 547
Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
Mucha, R. F., & Herz, A. (1985) · Psychopharmacology · doi:10.1007/bf00432213 · Cited by 515
Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513
κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses
McLaughlin, J. P., Marton-Popovici, M., & Chavkin, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05674.2003 · Cited by 505
A key role for corticotropin-releasing factor in alcohol dependence
Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.006 · Cited by 503
Self-citation
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis
O’Malley, S. S., Krishnan‐Sarin, S., Farren, C. K., Sinha, R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s002130100919 · Cited by 492
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046433 · Cited by 485
Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat
Swanson, L. W., & Simmons, D. M. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902850402 · Cited by 478
Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston-Jones, G. (2000) · Nature · doi:10.1038/35000212 · Cited by 462
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress
Imaki, T., Nahan, J., RIVIER, C. L., Sawchenko, P., & Vale, W. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00585.1991 · Cited by 434
The dark side of emotion: the addiction perspective
Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433
Self-citation
Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406
Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus
Makino, S., Gold, P. W., & Schulkin, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91862-7 · Cited by 400
Self-citation
The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398
Self-citation
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389
Self-citation
Brain stress systems in the amygdala and addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388
Self-citation
Dynorphin and the pathophysiology of drug addiction
Shippenberg, T. S., Zapata, A., & Chefer, V. I. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.011 · Cited by 387
Amygdala and extended amygdala
Alheid, G. F. (1995) · Medical Entomology and Zoology · Cited by 385
Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats
Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381
Self-citation
Allostasis, amygdala, and anticipatory angst
Schulkin, J., McEwen, B. S., & Gold, P. W. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90051-5 · Cited by 380
Obsessive-Compulsive-Related Disorders
Black, D. W. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1425 · Cited by 358
A Role for the Bed Nucleus of the Stria Terminalis, But Not the Amygdala, in the Effects of Corticotropin-Releasing Factor on Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. M., & Stewart, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-j0006.1999 · Cited by 347
Alcohol dependence as a chronic pain disorder
Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347
Self-citation
Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.007 · Cited by 336
Self-citation
Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF).
RIVIER, C. L., BRUHN, T. O., & Vale, W. G. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21776-1 · Cited by 328
Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior
Shepard, J. D., Barron, K. W., & Myers, D. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02019-9 · Cited by 321
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0069-12.2012 · Cited by 319
Self-citation
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318
Self-citation
Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.
Piazza, P. V., Deroche‐Gamonet, V., Deminière, J.-M., Maccari, S., Moal, M. L., & Simon, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11738 · Cited by 313
Safety and efficacy of patient-controlled analgesia
Macintyre, P. E. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.36 · Cited by 313
Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent
Compton, P., Charuvastra, V. C., & Ling, W. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00200-3 · Cited by 311
Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence
Diana, M., Pistis, M., Carboni, S., Gessa, G. L., & Rossetti, Z. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7966 · Cited by 309
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
Land, B. B., Bruchas, M. R., Schattauer, S., Giardino, W. J., Aita, M., Messinger, D., Hnasko, T. S., Palmiter, R. D., & Chavkin, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910705106 · Cited by 301
Hyperalgesic responses in methadone maintenance patients
Doverty, M., White, J. M., Somogyi, A. A., Bochner, F., Ali, R., & Ling, W. (2001) · Pain · doi:10.1016/s0304-3959(00)00391-2 · Cited by 297
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state
Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294
Self-citation
Addiction: failure of control over maladaptive incentive habits
Belin, D., Belin‐Rauscent, A., Murray, J. E., & Everitt, B. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.025 · Cited by 292
Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys.
Kalin, N. H., Larson, C. L., Shelton, S. E., & Davidson, R. J. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.2.286 · Cited by 282
Roles of the Amygdala and Bed Nucleus of the Stria Terminalis in Fear and Anxiety Measured with the Acoustic Startle Reflex
DAVIS, M., Walker, D. L., & LEE, Y. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48289.x · Cited by 280
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
Funk, C. K., Zorrilla, E. P., Lee, M.-J., Rice, K. C., & Koob, G. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.063 · Cited by 276
Self-citation
Conditioned Withdrawal Drives Heroin Consumption and Decreases Reward Sensitivity
Kenny, P. J., Chen, S. A., Kitamura, O., Markou, A., & Koob, G. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0740-06.2006 · Cited by 275
Self-citation
Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men
Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266
Obsessive-compulsive-related disorders
Hollander, E. (1993) · American Psychiatric Press eBooks · Cited by 262
Social Defeat Stress-Induced Behavioral Responses are Mediated by the Endogenous Kappa Opioid System
McLaughlin, J. P., Li, S., Valdez, J., Chavkin, T. A., & Chavkin, C. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300872 · Cited by 253
Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis
Parsons, L. H., & Justice, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)90984-u · Cited by 252
Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus
Makino, S., Gold, P. W., & Schulkin, J. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)90961-x · Cited by 249
Self-citation
A Double‐Blind, Placebo‐Controlled Pilot Study to Evaluate the Efficacy and Safety of Oral Nalmefene HCI for Alcohol Dependence
Mason, B. J., Ritvo, E. C., Morgan, R. O., Salvato, F., Goldberg, G., Welch, B., & Mantero-Atienza, E. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00098.x · Cited by 243
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
George, O., Sanders, C., Freiling, J., Grigoryan, E., Vu, S., Allen, C. D., Crawford, E. F., Mandyam, C. D., & Koob, G. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116523109 · Cited by 239
Self-citation
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism
Gehlert, D. R., Cippitelli, A., Thorsell, A., Lê, A. D., Hipskind, P. A., Hamdouchi, C., Lu, J., Hembre, E. J., Cramer, J. W., Song, M., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-06.2007 · Cited by 239
Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake
Olive, M. F., Koenig, H. N., Nannini, M. A., & Hodge, C. W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00748-1 · Cited by 237
Asymmetric Frontal Brain Activity, Cortisol, and Behavior Associated with Fearful Temperament in Rhesus Monkeys
Kalin, N. H., Larson, C., Shelton, S. E., & Davidson, R. J. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0072 · Cited by 235
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system
Redila, V. A., & Chavkin, C. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1122-y · Cited by 234
Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats
Knoll, A. T., Meloni, E. G., Thomas, J. B., Carroll, F. I., & Carlezon, W. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127415 · Cited by 227
Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal
Heinrichs, S. C., Menzaghi, F., Schulteis, G., Koob, G. F., & Stinus, L. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199501000-00011 · Cited by 226
Self-citation
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79828 · Cited by 218
Self-citation
Chronic Daily Ethanol and Withdrawal: 1. Long-Term Changes in the Hypothalamo-Pituitary-Adrenal Axis
Rasmussen, D. D., Boldt, B. M., Bryant, C. A., Mitton, D. R., Larsen, S. A., & Wilkinson, C. W. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01988.x · Cited by 216
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain
Shurman, J., Koob, G. F., & Gutstein, H. B. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00881.x · Cited by 215
Self-citation
Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
Blomeyer, D., Treutlein, J., Esser, G., Schmidt, M. H., Schumann, G., & Laucht, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.026 · Cited by 211
Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
Walker, B. M., Zorrilla, E. P., & Koob, G. F. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00226.x · Cited by 201
Self-citation
Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary
Meijer, O. C., Steenbergen, P. J., & de Kloet, E. R. (2000) · Endocrinology · doi:10.1210/endo.141.6.7489 · Cited by 200
Suppression of the HPA Axis Stress‐Response: Implications for Relapse
Adinoff, B. H., Junghanns, K., Kiefer, F., & Krishnan‐Sarin, S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000176356.97620.84 · Cited by 200
Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?
Peciña, S., Schulkin, J., & Berridge, K. C. (2006) · BMC Biology · doi:10.1186/1741-7007-4-8 · Cited by 194
Self-citation
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 188
Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Treutlein, J., Kissling, C., Frank, J., Wiemann, S., Dong, L., Depner, M., Saam, C., Lascorz, J., Soyka, M., Preuss, U. W., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001813 · Cited by 186
Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
Fu, Y., & Neugebauer, V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0227-08.2008 · Cited by 184
Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress
Wand, G. S., Oswald, L. M., McCaul, M. E., Wong, D. F., Johnson, E., Zhou, Y., Kuwabara, H., & Kumar, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301373 · Cited by 178
Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.
Diana, M., Pistis, M., Muntoni, A. L., & Gessa, G. L. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24484-6 · Cited by 170
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning
Kolber, B. J., Roberts, M. S., Howell, M. P., Wozniak, D. F., Sands, M. S., & Muglia, L. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803216105 · Cited by 169
Cocaine
Dyke, C. V., & Byck, R. (1982) · Scientific American · doi:10.1038/scientificamerican0382-128 · Cited by 161
The obsessive-compulsive spectrum disorders
Hollander, E., & Benzaquen, S. D. (1997) · International Review of Psychiatry · doi:10.1080/09540269775628 · Cited by 159
Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism
Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K., Wee, S., Park, P. E., Schulteis, G., & Koob, G. F. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.006 · Cited by 158
Self-citation
Replication and extension of Marlatt's taxonomy of relapse precipitants: overview of procedures and results
Lowman, C., Allen, J., & Stout, R. L. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02327.x · Cited by 157
Neurobiology of dysregulated motivational systems in drug addiction
Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157
Self-citation
Processing of Nociceptive Mechanical and Thermal Information in Central Amygdala Neurons With Knee-Joint Input
Neugebauer, V., & Li, W. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00264.2001 · Cited by 153
Dynorphin, dysphoria and dependence: the stress of addiction
Chavkin, C., & Koob, G. F. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.258 · Cited by 149
Self-citation
The Effects of Alcohol on the Central Nervous System in Humans
Begleiter, H., & Platz, A. (1972) · Springer eBooks · doi:10.1007/978-1-4684-0895-9_10 · Cited by 145
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
Chartoff, E. H., Sawyer, A. M., Rachlin, A. B., Potter, D., Pliakas, A. M., & Carlezon, W. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.014 · Cited by 144
Key Role for the Epsilon Isoform of Protein Kinase C in Painful Alcoholic Neuropathy in the Rat
Dina, O. A., Barletta, J. A., Chen, X., Mutero, A., Martin, A., Messing, R. O., & Levine, J. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08614.2000 · Cited by 142
Corticotropin releasing factor, stress and behavior
Koob, G. F., Heinrichs, S. C., Menzaghi, F., Pich, E. M., & Britton, K. T. (1994) · Seminars in Neuroscience · doi:10.1006/smns.1994.1029 · Cited by 141
Self-citation
Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3′-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats
Scherma, M., Panlilio, L. V., Fadda, P., Fattore, L., Gamaleddin, I., Foll, B. L., Justinová, Z., Mikics, É., Haller, J., Medalie, J., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.142224 · Cited by 139
Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study
Compton, P., Athanasos, P., & Elashoff, D. (2003) · The Journal of Pain · doi:10.1016/j.jpain.2003.08.003 · Cited by 138
Group II Metabotropic and α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA)/Kainate Glutamate Receptors Regulate the Deficit in Brain Reward Function Associated with Nicotine Withdrawal in Rats
Kenny, P. J., Gasparini, F., & Markou, A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052027 · Cited by 138
Pain-Related Anxiety-Like Behavior Requires CRF1 Receptors in the Amygdala
Ji, G., Fu, Y., Ruppert, K. A., & Neugebauer, V. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-13 · Cited by 137
Spino (trigemino) parabrachiohypothalamic pathway: electrophysiological evidence for an involvement in pain processes
Bester, H., Menéndez, L., Besson, J., et al. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.568 · Cited by 137
κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats
Nealey, K. A., Smith, A. W., Davis, S. M., Smith, D. G., & Walker, B. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.012 · Cited by 133
Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain Reward Function and Stress-Induced Relapse
Bruijnzeel, A. W., Prado, M., & Isaac, S. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.010 · Cited by 132
A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress
Dallman, M. F., Akana, S. F., Laugero, K. D., Gómez-Oliver, F., Manalo, S. L., Bell, M. E., & Bhatnagar, S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00100-8 · Cited by 129
Increased pain sensitivity in alcohol withdrawal syndrome
Jochum, T., Boettger, M. K., Burkhardt, C., Juckel, G., & Bär, K. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.11.008 · Cited by 128
CRH: the link between hormonal-, metabolic- and behavioral responses to stress
Kovács, K. J. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.05.003 · Cited by 126
Pain in the brain: are hormones to blame?
Blackburn-Munro, G., & Blackburn-Munro, R. (2003) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(02)00004-8 · Cited by 124
Differential Effects of CRF1 and CRF2 Receptor Antagonists on Pain-Related Sensitization of Neurons in the Central Nucleus of the Amygdala
Ji, G., & Neugebauer, V. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00135.2007 · Cited by 123
Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala
Cook, C. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.06.013 · Cited by 123
Relapse research and the Reasons for Drinking Questionnaire: a factor analysis of Marlatt’s relapse taxonomy
ZYWIAK, W. H., CONNORS, G. J., MAISTO, S. A., & WESTERBERG, V. S. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02332.x · Cited by 121
Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration—comparison with CB1 receptor blockade
Forget, B., Coen, K. M., & Foll, B. L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1569-5 · Cited by 121
Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.004 · Cited by 120
Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake
Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., & Koob, G. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1979-13.2013 · Cited by 119
Self-citation
Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
Wee, S., Orío, L., Ghirmai, S., Cashman, J. R., & Koob, G. F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1563-y · Cited by 119
Self-citation
Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence
Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., & Roberto, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.004 · Cited by 116
Self-citation
Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., & Weiss, F. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.027 · Cited by 112
Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats
Tilson, H. A., Rech, R. H., & Stolman, S. (1973) · Psychopharmacologia · doi:10.1007/bf00429309 · Cited by 107
Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats
Bruijnzeel, A. W., Zislis, G., Wilson, C., & Gold, M. S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301192 · Cited by 107
Rats orally self-administer corticosterone
Deroche‐Gamonet, V., Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90837-d · Cited by 105
Neuroclinical Framework for the Role of Stress in Addiction
Kwako, L. E., & Koob, G. F. (2017) · Chronic Stress · doi:10.1177/2470547017698140 · Cited by 105
Self-citation
Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala
Thompson, B. L., Erickson, K., Schulkin, J. A., & Rosen, J. B. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00216-x · Cited by 103
Self-citation
Stress modulates illness-course of substance use disorders: a translational review
Lijffijt, M., Hu, K., & Swann, A. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00083 · Cited by 103
Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds
Schmid, B., Blomeyer, D., Treutlein, J., Zimmermann, U. S., Buchmann, A. F., Schmidt, M. H., Esser, G., Rietschel, M., Banaschewski, T., Schumann, G., et al. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990290 · Cited by 103
Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor
Bryce, C. A., & Floresco, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.15 · Cited by 102
Abnormal pain response in pain-sensitive opiate addicts after prolonged abstinence predicts increased drug craving
Ren, Z.-Y., Shi, J., Epstein, D. H., Wang, J., & Lu, L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1472-0 · Cited by 101
Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP
Enoch, M., Shen, P., Ducci, F., Yuan, Q., Liu, J., White, K. V., Albaugh, B., Hodgkinson, C. A., & Goldman, D. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003620 · Cited by 101
Stress Seeking: Selected Behavioral Characteristics of Elite Rock Climbers
Robinson, D. W. (1985) · Journal of Sport Psychology · doi:10.1123/jsp.7.4.400 · Cited by 100
Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking
Gilpin, N. W., Misra, K., & Koob, G. F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.04.006 · Cited by 97
Self-citation
Species and sex differences in brain distribution of corticotropin‐releasing factor receptor subtypes 1 and 2 in monogamous and promiscuous vole species
Lim, M. M., Nair, H. P., & Young, L. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20532 · Cited by 95
Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats
Schulteis, G., & Liu, J. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.06.008 · Cited by 94
Life events-induced decrease of corticosteroid type I receptors is associated with reduced corticosterone feedback and enhanced vulnerability to amphetamine self-administration
Maccari, S., Piazza, P. V., Deminière, J. M., Lemaire, V., Mormède, P., Simon, H., Angelucci, L., & Moal, M. L. (1991) · Brain Research · doi:10.1016/0006-8993(91)90568-g · Cited by 92
Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats
Thorsell, A., Repunte-Canonigo, V., O'Dell, L. E., Chen, S. A., King, A. R., Lekic, D., Koob, G. F., & Paolo Sanna, P. (2007) · Brain · doi:10.1093/brain/awm033 · Cited by 91
Self-citation
Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research
Carlezon, Jr., Nestler, E. J., & Neve, R. L. (2000) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v14.i1.30 · Cited by 90
Corticotropin-Releasing Factor Within the Central Nucleus of the Amygdala and the Nucleus Accumbens Shell Mediates the Negative Affective State of Nicotine Withdrawal in Rats
Marcinkiewcz, C. A., Prado, M., Isaac, S. K., Marshall, S. A., Rylkova, D., & Bruijnzeel, A. W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.231 · Cited by 89
Association of Low-Voltage Alpha EEG With a Subtype of Alcohol Use Disorders
Enoch, M., White, K. V., Harris, C. R., Robin, R. W., Ross, J., Rohrbaugh, J., & Goldman, D. A. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04352.x · Cited by 87
Central administration of corticotropin releasing factor induces long-term sensitization to d-amphetamine
Cador, M., Cole, B. J., Koob, G. F., Stinus, L., & Moal, M. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)90982-s · Cited by 87
Self-citation
“The free market” and the Asian crisis
Jones, G. (2000) · Critical Review · doi:10.1080/08913810008443546 · Cited by 85
Behavioral Stress May Increase the Rewarding Valence of Cocaine-Associated Cues Through a Dynorphin/κ-Opioid Receptor-Mediated Mechanism without Affecting Associative Learning or Memory Retrieval Mechanisms
Schindler, A. G., Li, S., & Chavkin, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.67 · Cited by 85
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
Grieder, T. E., George, O., Tan, H., George, S. R., Foll, B. L., Laviolette, S. R., & van der Kooy, D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114422109 · Cited by 84
Stress-Induced and Cue-Induced Craving for Alcohol in Heavy Drinkers: Preliminary Evidence of Genetic Moderation by the OPRM1 and CRH-BP Genes
Ray, L. A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01333.x · Cited by 83
A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats
Jang, C., Whitfield, T., Schulteis, G., Koob, G. F., & Wee, S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2864-0 · Cited by 83
Self-citation
Pharmacological approaches to reducing craving in patients with alcohol use disorders
Haass-Koffler, C. L., Leggio, L., & Kenna, G. A. (2014) · CNS Drugs · doi:10.1007/s40263-014-0149-3 · Cited by 83
Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure
Thorsell, A., Slawecki, C. J., & Ehlers, C. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.016 · Cited by 83
Alcohol-induced pseudo-Cushing’s disease: a study of prevalence with review of the literature
Kirkman, S., & Nelson, D. H. (1988) · Metabolism · doi:10.1016/0026-0495(88)90141-2 · Cited by 79
Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats
Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.293 · Cited by 79
Self-citation
Ethanol withdrawal induces hyperalgesia mediated by PKCε
Dina, O. A., Messing, R. O., & Levine, J. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04886.x · Cited by 79
The amygdala: Different pains, different mechanisms
Neugebauer, V. (2006) · Pain · doi:10.1016/j.pain.2006.10.004 · Cited by 76
Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence
Gilpin, N. W., Stewart, R. B., Murphy, J. M., Li, T., & Badia‐Elder, N. E. (2003) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000065723.93234.1d · Cited by 76
Brain reward deficits accompany naloxone-precipitated withdrawal from acute opioid dependence
LIU, J., & Schulteis, G. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.06.006 · Cited by 76
κ opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake
Whitfield, T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1978-13.2015 · Cited by 75
Self-citation
The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats
Ciccocioppo, R., Economidou, D., Fedeli, A., & Massi, M. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00112-4 · Cited by 74
Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction
Koob, G. F. (2017) · Psychopharmacology · doi:10.1007/s00213-016-4484-6 · Cited by 73
Self-citation
Chronic CRF1receptor blockade reduces heroin intake escalation and dependence‐induced hyperalgesia
Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., & Koob, G. F. (2015) · Addiction Biology · doi:10.1111/adb.12120 · Cited by 69
Self-citation
Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function
Gray, J. M., Wilson, C. D., Lee, T. T.-Y., Pittman, Q. J., Deussing, J. M., Hillard, C. J., McEwen, B. S., Schulkin, J. A., Karatsoreos, I. N., Patel, S., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.004 · Cited by 69
Self-citation
Pain perception in drug-free and in methadone-maintained human ex-addicts
Ho, A., & Dole, V. P. (1979) · Experimental Biology and Medicine · doi:10.3181/00379727-162-40689 · Cited by 69
Single‐Nucleotide Polymorphisms in Corticotropin Releasing Hormone Receptor 1 Gene (CRHR1) Are Associated With Quantitative Trait of Event‐Related Potential and Alcohol Dependence
Chen, A. C. H., Manz, N., Tang, Y., Rangaswamy, M., Almasy, L. A., Samuel Kuperman, C., Nürnberger, J. I., O’Connor, S., Edenberg, H. J., Schuckit, M. A., et al. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01173.x · Cited by 68
Corticosterone Can Facilitate as Well as Inhibit Corticotropin-Releasing Hormone Gene Expression in the Rat Hypothalamic Paraventricular Nucleus*
Tanimura, S. M., & Watts, A. G. (1998) · Endocrinology · doi:10.1210/endo.139.9.6192 · Cited by 67
Kappa Opioid Receptor-Mediated Dysregulation of Gamma-Aminobutyric Acidergic Transmission in the Central Amygdala in Cocaine Addiction
Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., & Roberto, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.028 · Cited by 65
Self-citation
The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats.
Adamczyk, P., McCreary, A. C., Przegaliński, E., et al. (2009) · PubMed · Cited by 63
Hypothalamic-Pituitary-Adrenocortical Axis Activity: A Target of Pharmacological Anticraving Treatment?
Kiefer, F., Jahn, H., Otte, C., Naber, D., & Wiedemann, K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.023 · Cited by 61
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats
Bruijnzeel, A. W., Ford, J. L., Rogers, J. A., Scheick, S., Ji, Y. R., Bishnoi, M., & Alexander, J. C. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.12.001 · Cited by 61
Effects of Neuropeptide Y on Appetitive and Consummatory Behaviors Associated With Alcohol Drinking in Wistar Rats With a History of Ethanol Exposure
Thorsell, A., Slawecki, C. J., & Ehlers, C. L. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000160084.13148.02 · Cited by 54
Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats
Bruijnzeel, A. W., Bishnoi, M., van Tuijl, I. A., Keijzers, K. F. M., Yavarovich, K. R., Pasek, T. M., Ford, J. L., Alexander, J. C., & Yamada, H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1970-0 · Cited by 53
Effects of corticosterone on corticotrophin‐releasing hormone and gastrin‐releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex)
Merali, Z., Anisman, H., James, J. S., Kent, P., & Schulkin, J. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06281.x · Cited by 53
Self-citation
Adrenocorticotropin Responses to Naloxone in Sons of Alcohol-Dependent Men
Wand, G. S., Mangold, D. L., & Ali, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5373 · Cited by 52
The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement
Barbier, E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Juergens, N., Park, P. E., Misra, K., Cheng, K., Rice, K. C., Schank, J. R., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.261 · Cited by 50
Self-citation
Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects
Tan, H., Bishop, S. F., Lauzon, N. M., Sun, N., & Laviolette, S. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.12.008 · Cited by 49
Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli
Merali, Z., Michaud, D. S., McIntosh, J. F., Kent, P., & Anisman, H. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.014 · Cited by 44
Enhanced Upregulation of CRH mRNA Expression in the Nucleus Accumbens of Male Rats after a Second Injection of Methamphetamine Given Thirty Days Later
Cadet, J. L., Brannock, C., Ladenheim, B., McCoy, M. T., Krasnova, I. N., Lehrmann, E., Becker, K. G., & Jayanthi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084665 · Cited by 43
Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
Merali, Z., Kent, P., Michaud, D. S., McIntyre, D., & Anisman, H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02556-2 · Cited by 40
Genetics Talks to Epigenetics? The Interplay Between Sequence Variants and Chromatin Structure
Zaina, S., Pérez-Luque, E. L., & Lund, G. (2010) · Current Genomics · doi:10.2174/138920210791616662 · Cited by 39
Prediction of the Risk of Comorbid Alcoholism in Schizophrenia by Interaction of Common Genetic Variants in the Corticotropin-Releasing Factor System
Ribbe, K. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.100 · Cited by 34
Defining the role of corticotropin releasing factor binding protein in alcohol consumption
Haass-Koffler, C. L., Henry, A. T., Melkus, G., Simms, J. A., Naemmuddin, M., Nielsen, C. K., Lasek, A. W., Magill, M., Schwandt, M. L., Momenan, R., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.208 · Cited by 33
Cocaine-induced elevation of plasma corticosterone is mediated by different neurotransmitter systems in rats
Sarnyai, Z., Bíró, É., & Telegdy, G. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90106-4 · Cited by 20
Conditioned activity to amphetamine in transgenic mice expressing and antisense RNA against the glucocorticoid receptor.
Steckler, T., & Holsboer, F. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.1.207 · Cited by 19
History of Behavioral Neuroscience
Koob, G. F., Moal, M. L., Thompson, R. F., & Zola, S. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-045396-5.00121-4 · Cited by 18
Self-citation
Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats
Qi, X., Guzhva, L., Ji, Y. R., & Bruijnzeel, A. W. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.031 · Cited by 16

Flagged first, then by citations

Research works printed but not linked: 1

Habib, 2000, CRH-1 receptor antagonism exerts antidepressant- and anxiolytic-like effects in attenuating stress ulcerogenesis, FASEB J., 14, A338

Sorted by citations

Les professionnels de santé face à la pandémie de la maladie à coronavirus (COVID-19) : quels risques pour leur santé mentale ?
El-Hage, W., Hingray, C., Lemogne, C., Yrondi, A., Brunault, P., Bienvenu, T., Etain, B., Paquet, C., Gohier, B., Bennabi, D., et al. (2020) · L'Encéphale · doi:10.1016/j.encep.2020.04.008 · Cited by 457
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Self-citation
Allostasis: A brain-centered, predictive mode of physiological regulation
Schulkin, J., & Sterling, P. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.010 · Cited by 265
Self-citation
Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications
Wiss, D. A., Avena, N., & Gold, M. (2020) · Nutrients · doi:10.3390/nu12113521 · Cited by 66
Driving the downward spiral: alcohol-induced dysregulation of extended amygdala circuits and negative affect
Centanni, S. W., Bedse, G., Patel, S., & Winder, D. G. (2019) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14178 · Cited by 58
Stress and opioid use disorder: A systematic review
MacLean, R. R., Armstrong, J. L., & Sofuoglu, M. (2019) · Addictive Behaviors · doi:10.1016/j.addbeh.2019.05.034 · Cited by 43
A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
Wiss, D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00193 · Cited by 41
Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats
Khom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105610 · Cited by 23
Clinical neuroscience of addiction: what clinical psychologists need to know and why
Ray, L. A., & Grodin, E. N. (2021) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-114309 · Cited by 18
Media Exposure and Substance Use Increase during COVID-19
Amram, O., Borah, P., Kubsad, D., & McPherson, S. M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126318 · Cited by 11

Authors: Koob, G. F., & Schulkin, J.
Affiliations: National Institute on Drug Abuse (US)
Georgetown University (US)
Corresponding author: Koob, George F.
ORCID: Koob, George F.
Schulkin, Jay
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2019-11
Volume: 106
Pages: 245-262
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2018.09.008
OpenAlex: W2891830541
Semantic Scholar: 81d0dcacfe6b2902b48e20cdfc79fb37ce6694bc
Cited by: 315
References: 204
Citations by year: 2026: 36 · 2025: 53 · 2024: 32 · 2023: 47 · 2022: 31 · 2021: 50 · 2020: 40 · 2019: 26
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: addiction, stress, allostasis, allostatic load, corticotropin-releasing factor, drug addiction, addiction cycle, withdrawal, emotion regulation, neurocircuitry
MeSH terms: Animals, Brain, Humans, Stress, Psychological, Substance-Related Disorders, Allostasis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Addiction and stress: An allostatic view

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks