Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, Christiane, Dannlowski, Udo, Bräuer, David, Stevens, Stephan, Laeger, Inga, Wittmann, Hannah, Kugel, Harald, Dobel, Christian +11 more·2015·Neuropsychopharmacology
Cited by (192)
Items 101–192 of 192
- Neuroimaging Epigenetics: Challenges and Recommendations for Best PracticesKatie Lancaster, James P. Morris, Jessica J. Connelly · 2017 · Neuroscience
- Interactions Between Oxytocin Receptor Gene Methylation and Callous-Unemotional Traits Impact Socioaffective Brain Systems in Conduct-Disordered OffendersAghajani, Moji, Klapwijk, Eduard T., Colins, Olivier F., Ziegler, Christiane, Domschke, Katharina, Vermeiren, Robert R.J.M., van der Wee, Nic J.A. · 2018 · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety: Role in complicated griefMiriam A. Schiele, Barbara Costa, Marianna Abelli, Claudia Martini, David S. Baldwin, Katharina Domschke, Stefano Pini · 2018 · The World Journal of Biological Psychiatry
- Oxytocin strengthens the link between provocation and aggression among low anxiety peopleMichaela Pfundmair, Annika Reinelt, C. Nathan DeWall, Lisa Feldmann · 2018 · Psychoneuroendocrinology
- Oxytocin Signaling Acts as a Marker for Environmental Stressors in ZebrafishHsin-Ju Chuang, Chun-Yung Chang, Huai-Ping Ho, Ming‐Yi Chou · 2021 · International Journal of Molecular Sciences
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implicationsMadelyn Gailey Nance, Kelsey M. Sullivan, Meghan H. Puglia · 2024 · Pediatric Research
- Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric DisordersDonatella Marazziti, Phuoc-Tan Diep, Carol Sue Carter, Manuel Glauco Carbone · 2022 · Current Medicinal Chemistry
- Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic DisordersTyler Barrett Grove, Kyle Jon Burghardt, A. Zarina Kraal, Ryan J. Dougherty, Stephan Floyd Taylor, Vicki L. Ellingrod · 2016 · Complex Psychiatry
- Familial Factors in the Development of Social Anxiety DisorderChristine M. Olson · 2021 · Journal of Psychosocial Nursing and Mental Health Services
- DNA Methylation: A Mediator Between Parenting Stress and Adverse Child Development?Rosa H. Mulder, Jolien Rijlaarsdam, Marinus H. van IJzendoorn · 2017 · Springer eBooks
- Personalized Clinical Approaches to Anxiety DisordersPerna, Giampaolo, Alciati, Alessandra, Sangiorgio, Erika, Caldirola, Daniela, Nemeroff, Charles B. · 2020 · Advances in Experimental Medicine and Biology
- Methylation of oxytocin related genes and early life trauma together shape the N170 response to human facesFranca H. Parianen Lesemann, Hannah Spencer, Estrella Rocio Montoya, Eline J. Kraaijenvanger, Yujie He, Susan Branje, Marco P. Boks, Peter A. Bos · 2020 · European Neuropsychopharmacology
- Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorderJanna Marie Bas‐Hoogendam, Henk van Steenbergen, Jennifer Urbano Blackford, Renaud Tissier, Nic J.A. van der Wee, Pieter Michiel Westenberg · 2019 · Depression and Anxiety
- A dog's life: Early life histories influence methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes, cortisol levels, and attachment stylesSamantha L. Awalt, Lidia Boghean, David L. Klinkebiel, Rosemary Strasser · 2024 · Developmental Psychobiology
- Genetics of social anxiety disorder: a systematic reviewAmi Baba, Stefan M. Kloiber, Gwyneth C. Zai · 2021 · Psychiatric Genetics
- A variation in the infant oxytocin receptor gene modulates infant hippocampal volumes in association with sex and prenatal maternal anxietyHenriette Acosta, Jetro J. Tuulari, Katri Kantojärvi, John D. Lewis, Niloofar Hashempour, Noora M. Scheinin, Satu J. Lehtola, Vladimir Fonov, D. Louis Collins, Alan Charles Evans et al. · 2020 · Psychiatry Research Neuroimaging
- Mild internet use is associated with epigenetic alterations of key neurotransmission genes in salivary DNA of young university studentsEugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo E.M. Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Maria Dell’Osso et al. · 2023 · Scientific Reports
- Perceived Parental Support and Psychological Control, DNA Methylation, and Loneliness: Longitudinal Associations Across Early AdolescenceYentl Koopmans, Stefanie A. Nelemans, Guy Bosmans, Wim Van Den Noortgate, Karla G. Van Leeuwen, Luc Goossens · 2023 · Journal of Youth and Adolescence
- The Multifaceted Role of Oxytocinergic System and OXTR GeneRakibul Hasan · 2024 · Global Medical Genetics
- Effects of human-animal interaction on salivary and urinary oxytocin in children and dogsGitanjali E. Gnanadesikan, Katherine M. King, Elizabeth Carranza, Abigail C. Flyer, Gianna Ossello, Paige G. Smith, Netzin G. Steklis, Horst Dieter Steklis, Carol Sue Carter, Jessica J. Connelly et al. · 2024 · Psychoneuroendocrinology
- Salivary oxytocin and amygdalar alterations in functional neurological disordersSamantha Weber, Natascha Stoffel, Juan J. Ansede‐Bermejo, Raquel Cruz, Álvaro Del Real Bolt, R.M. Bruckmaier, Ángel Carracedo, Selma Aybek · 2024 · Brain Communications
- Evaluation of Stress Management and Stress Prevention Using Epigenetic MarkersMartin Stoffel, Elena Gardini, Johannes C. Ehrenthal, Elvira Abbruzzese, Beate Ditzen · 2020 · Verhaltenstherapie
- The role of epigenetics in anxiety disordersAli Azargoonjahromi · 2023 · Molecular Biology Reports
- OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorderKatrin Elisabeth Giel, Kathrin Schag, Elisabeth Johanna Leehr, Isabelle Mack, Lea-Sarah Schuster, Ariane Wiegand, Stephan Zipfel, Manfred Hallschmid, Vanessa Nieratschker · 2022 · Clinical Epigenetics
- The potential of oxytocin as a therapeutic target for psychiatric disordersStefanie Martinetz, Inga D. Neumann · 2015 · Expert Opinion on Therapeutic Targets
- Oxytocin and social learning in socially anxious men and womenAleya Flechsenhar, Seth M. Levine, Laura Elisa Müller, Sabine Christiane Herpertz, Katja Bertsch · 2024 · Neuropharmacology
- A targeted long-read sequencing approach questions the association of OXTR methylation with high-functioning autismJelte Wieting, Kirsten Jahn, Stefan Bleich, Helge Frieling, Maximilian Deest · 2023 · Clinical Epigenetics
- Epigenetic Modification of OXTR is Associated with Openness to ExperienceBrian W. Haas, Alicia K. Smith, Shota Nishitani · 2018 · Personality Neuroscience
- Evaluation von Stressprävention und Stressbewältigung mittels epigenetischer MarkerMartin Stoffel, Elena Gardini, Johannes C. Ehrenthal, Elvira Abbruzzese, Beate Ditzen · 2020 · Verhaltenstherapie
- AngststörungenKatharina Domschke, Hans‐Peter Kapfhammer, Jürgen Deckert · 2017 · Springer eBooks
- Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic reviewDiana Pinto Prata, Marta Silva · 2022 · Neuroscience & Biobehavioral Reviews
- Oxytocin and eating disorders: Knowledge gaps and future directionsJanice D. Russell, Glenn E. Hunt · 2023 · Psychoneuroendocrinology
- Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parentingKeisuke Noto, Akihito Suzuki, Toshinori Shirata, Yoshihiko Matsumoto, Haruka Muraosa, Kaoru Goto, Koichi Otani · 2021 · Brain and Behavior
- OXTR polymorphisms associated with severity and treatment responses of schizophreniaXue Lv, Yue-Sen Hou, Zhaohui Zhang, Weihua Yue · 2024 · Schizophrenia
- Methylation of the Oxytocin, Oxytocin Receptor, and Vasopressin Gene Promoters in Tobacco Use Disorder during CessationPhileas Johannes Proskynitopoulos, Stefan Bleich, Marc Andre Nicolas Muschler, Vanessa Buchholz, Helge Frieling, Alexander Glahn, Mathias Rhein · 2024 · Neuropsychobiology
- Functional characterization of OXTR -associated enhancersDianne Laboy Cintrón, Rory R. Sheng, Nadav Ahituv · 2025 · Human Molecular Genetics
- Human DNA methylation and the cortisol response to an acute psychological stressor: A systematic review and meta-analysisDavid Balfour, Zoe Kleinig, Murthy Mittinty, Sarah Cohen‐Woods · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- The mediating role of transmembrane protein 132D methylation in predicting the occurrence of panic disorder in physical abuseQianmei Yu, Chiyue Wang, Huazheng Xu, Yun Wu, Huachen Ding, Na Liu, Ning Zhang, Chun Wang · 2022 · Frontiers in Psychiatry
- Biological aging analysis based on DNA methylation status for social anxiety disorderNobuhiko Noguchi, Toshiyuki Shirai, Akira Suda, Saki Hattori, Masatoshi Miyauchi, Satoshi Okazaki, Junichi Fujita, Takeshi Asami, Ikuo Otsuka, Akitoyo Hishimoto · 2024 · Neuropsychopharmacology Reports
- Epigenetic Insights into Substance Use Disorder and Associated Psychiatric ConditionsAmbrose Loc Ngo, Christopher M Ahmad, Niki Gharavi Alkhansari, Linda Nguyen, Huiping Zhang · 2025 · Complex Psychiatry
- Genetics of anxiety disordersMichael G. Gottschalk, Katharina Domschke · 2020
- Oxytocin Receptor Exon III Methylation in the Umbilical Cord Blood of Newborns With Prenatal Exposure to Crack CocaineT. Baptista, L. A. de Azeredo, A. Zaparte, T. Viola, S. C. Coral, M. Nagai, F. R. Mangone, A. Pavanelli, J. Schuch, V. Mardini et al. · 2021 · Frontiers in Cell and Developmental Biology
- Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain functionHuachen Ding, Yuan Zhong, Na Liu, Huiqin Wu, Huazhen Xu, Yun Wu, Gang Liu, Shiting Yuan, Qi‐Gang Zhou, Chun Wang · 2022 · Frontiers in Aging Neuroscience
- Higher-order adaptive dynamical system modelling of epigenetic mechanisms in infant temperament shaped by prenatal maternal stressLabiba Aziz, Jan Treur A · 2024 · Cognitive Systems Research
- The sex-different effect of oxytocin receptor gene methylation on cerebral gray matter structures and clinical symptoms in Korean patients with panic disorderSubin Chung, Hyun-Ju Kim, Chun Il Park, Minji Bang, Sang-Hyuk Lee · 2025 · Journal of Psychiatric Research
- A systematic review of methylome-wide associations with anxiety disordersSarah J. Ingram, Lea Zillich, Miriam A. Schiele, Katharina Domschke, John M. Hettema, Shaunna L. Clark · 2026 · Translational Psychiatry
- Transcriptional Regulation, Signaling Pathways, and Subcellular Localization of Corticotropin-Releasing Factor Receptors in the Central Nervous SystemPaula Amado, Juan Zegers, Héctor E. Yarur, Katia Gysling · 2022 · Molecular Pharmacology
- Acute stress induces changes in epigenome-wide DNA methylationLea Zillich, Nathaly S. Czernin, Óscar Crespo Salvador, Elisabeth M. Hummel, Paul Pauli, Andreas Reif, J. Deckert, Katharina Domschke, Miriam A. Schiele · 2025 · Neuropsychopharmacology
- AngststörungenKatharina Domschke, Hans‐Peter Kapfhammer, Jürgen Deckert · 2016 · Springer eBooks
- Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric DisordersSareh Pandamooz, Mohammad Saied Salehi, Benjamin Jurek, Carl-Philipp Meinung, Negar Azarpira, Mehdi Dianatpour, Inga D. Neumann · 2023 · Stem Cell Reviews and Reports
- AngststörungenJens Plag, Andreas Ströhle · 2020 · Springer eBooks
- Developmental PlasticityEmanuela Saveria Gritti, Baptiste Barbot · 2020 · Springer eBooks
- Endogenous oxytocin levels in children with autism: Associations with cortisol levels and oxytocin receptor gene methylationMargaux Evenepoel, Moerkerke Matthijs, Nicky Daniëls, Viktoria Chubar, Stephan J. Claes, Jonathan D. Turner, Bart M. Vanaudenaerde, Lynn Willems, Johan Verhaeghe, Jellina Prinsen et al. · 2022 · medRxiv
- Translating neuroscience research to oral medicine: oxytocin and human behaviorDavid A. Nash · 2015 · Oral Diseases
- The Role of Oxytocin and Oxytocin Gene Receptor Methylation During Withdrawal Therapy in Males With Alcohol Use DisorderPhileas Johannes Proskynitopoulos, Alissa F. Haarmeyer, Stefan Bleich, Helge Frieling, Thomas Hillemacher, Alexander Glahn, Mathias Rhein · 2025 · Addiction Biology
- Anxiety DisordersJens Plag, Andreas Ströhle · 2023 · Springer eBooks
- GW117 induces anxiolytic effects by improving hippocampal functionsYaqi Yang, Murezati Tiliwaerde, Nana Gao, Wei Gu, Tingting Zhang, Zengliang Jin · 2024 · Pharmacology Biochemistry and Behavior
- Salivary Bioscience in Clinical Psychology and PsychiatryKate Ryan Kuhlman, Nestor L. Lopez‐Duran, Zahra Avah Mousavi · 2020 · Springer eBooks
- Developmental PlasticityEmanuela Saveria Gritti, Baptiste Barbot · 2019 · Springer eBooks
- Oxytocin Receptors and NeurobehaviorRobert Kumsta, Johannes C. S. Zang, Dirk Moser · 2016 · Epigenetics and human health
- Impact of early life experience on adult health.David T. Denhardt · 2017
- Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the FutureEunsoo Won, Byung‐Joo Ham, Yong‐Ku Kim · 2018 · Springer eBooks
- Altered DNA methylation of the oxytocin receptor gene is associated with susceptibility to psychosis and anhedonia-asociality in femalesMinji Bang, S.J. Kim, K.R. Kim, S.Y. Lee, J.Y. Park, E. Lee, J.I. Kang, S.K. An · 2019 · European Neuropsychopharmacology
- METHYLATION OF PROLACTIN AND OXYTOCIN HORMONE GENES; PHYSIOLOGICAL FUNCTIONS AND ROLES IN DISEASE STATESManoj G Tyagi, Deepak Gopal Shewade, Megha Chaudhary, Mohammed I Wani, Shyam S Yadav · 2019 · Journal of Biomedical and Pharmaceutical Research
- Fear and missing out : internet-treatment for social anxiety disorder in youthMartina Nordh · 2020 · Figshare
- Evaluating Methylation of the Oxytocin Receptor Gene and the Oxytocin Intergenic RegionLeonora King, Stéphanie Robins, Gary Chen, Gustavo Turecki, Phyllis Zelkowitz · 2021 · Methods in molecular biology
- Anxiety DisordersMargarita Sáenz-Herrero, Álvar Peña-Rotella, Ane Eizaguirre-Garcia, Karim Haidar · 2019 · Springer eBooks
- Genomics and epigenomics of anxiety and obsessive-compulsive disordersAngelika Erhardt, Manuel Mattheisen, Jürgen Deckert · 2022 · Elsevier eBooks
- References2018 · Elsevier eBooks
- Anxiety DisordersEleonora Piccoli, Simone Vanzetto, Lucia Cerolini, Dario Conti, Laura Celebre, Bernardo Maria Dell’Osso · 2024 · Cambridge University Press eBooks
- Neuroendocrine Regulation of AnxietyAnna Onisiforou, Panos Zanos, Polymnia Georgiou · 2024 · Springer eBooks
- Association Between Relational Mobility and DNA Methylation in Oxytocin Receptor Gene: A Social Epigenetic StudyShubing Li, Junko Yamada, Toru Ishihara, Kuniyuki Nishina, Shota Nishitani, Tetsuhiko Sasaki, Tetsuya Matsuda, Mino Inoue-Murayama, Haruto Takagishi · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Mental Disorders and DNA MethylationSeda Örenay-Boyacıoğlu, Olcay Boyacıoğlu, Ayşe Döndü · 2024 · Springer eBooks
- References2024 · Elsevier eBooks
- Anxiety DisordersHymie Anisman, Shawn P. Hayley, Alexander W. Kusnecov · 2024 · Elsevier eBooks
- A systematic review of methylome-wide associations with anxiety disordersSarah J. Ingram, Lea Zillich, Miriam A. Schiele, Katharina Domschke, John M. Hettema, Shaunna L. Clark · 2025 · medRxiv
- Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of SymptomsMaddalena Mauri, Silvia Grazioli, Carolina Bonivento, Alessandro Crippa, Roberto Giorda, Eleonora Maggioni, Fabiana Mambretti, Eleonora Rosi, Letizia Squarcina, Federica Tizzoni et al. · 2025 · Biomolecules
- Mental Disorders and DNA MethylationSeda Örenay-Boyacıoğlu, Olcay Boyacioglu, Ayşe Döndü · 2025 · Springer eBooks
- Social Neuroscience: Bridging Social and Biological Levels of AnalysisGreg J. Norman, Anita Restrepo, Gary G. Berntson · 2025 · Handbooks of sociology and social research
- Epigenetic Modification of the Oxytocin Receptor in Pregnancy Predicts Parent-infant Bonding and Postpartum Depressive SymptomsShannon M. Savell, Emma A. Page, Julia Pan, Travis S. Lillard, Robert E. Emery, Jessica J. Connelly · 2025 · Journal of Child and Family Studies
- Additional file 1 of Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expressionJoshua S. Danoff, Kelly L. Wroblewski, Andrew Graves, Graham C. Quinn, Allison M. Perkeybile, William M. Kenkel, Travis S. Lillard, Hardik I. Parikh, Golino, Hudson F., Gregory, Simon G. et al. · 2021 · Figshare
- Additional file 1 of A targeted long-read sequencing approach questions the association of OXTR methylation with high-functioning autismJelte Wieting, Kirsten Jahn, Stefan Bleich, Frieling, Helge, Deest, Maximilian · 2024 · Figshare
- Development and cross-tissue validation of a machine learning-based methylation profile score for the cortisol response to stressDavid Balfour, Murthy Mittinty, Duc Phuc Nguyen, Sarah Cohen‐Woods · 2026 · European Neuropsychopharmacology
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptorAmalia M. Skyberg, Jennifer H. Pfeifer · 2026 · Developmental Cognitive Neuroscience
- The oxytocinergic descending control of pain and its modulation by neonatal maternal separationMeggane Melchior · 2018 · theses.fr (ABES)
- A pilot study on the role of the oxytocinergic system in gut microbiome composition in children with autism: baseline associations and effects of intranasal oxytocinMargaux Evenepoel, Elise Tuerlinckx, Muriel Derrien, Matthijs Moerkerke, Jellina Prinsen, Arnau Vich Vila, Jean G. Steyaert, Nicky Daniëls, Bart Boets, Jeroen Raes et al. · 2026 · Brain Behavior and Immunity
- Anxiety DisordersMargarita Sáenz-Herrero, Mayte López-Atanes, Ana Espiga Izuzquiza, Luis Urgoiti González · 2026 · Springer eBooks
- Updated Freudian drive theory: childhood trauma, epigenetics, serotonin and beta endorphinMichael Kirsch · 2026 · Frontiers in Psychiatry
- Investigation of polygenic risk scores and subphenotypes in social anxiety disorderLisa Sindermann, Angelina Röhrig, Friederike Sophie David, B Schmidt, Katharina Domschke, Vanessa Nieratschker, Udo Dannlowski, Elisabeth Johanna Leehr, Eric Leibing, Markus Maria Nöthen et al. · 2026 · Translational Psychiatry
- Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness?Yentl Koopmans, Stefanie A. Nelemans, Patricia Bijttebier, Guy Bosmans, Wim Van Den Noortgate, Karla G. Van Leeuwen, Luc Goossens · 2026 · Developmental Psychobiology
- Associations between human oxytocin receptor gene promoter DNA methylation and brain structural connectome in panic disorder in KoreaHyun-Ju Kim, Chongwon Pae, Minji Bang, Il-Bin Kim, Sang-Hyuk Lee · 2026 · Journal of Affective Disorders
- Epigenetic influences on affect and emotion regulation: Insights from the oxytocin systemR. CRAIG GALLAGHER, Amalia M. Skyberg, JAMES P. MORRIS, Jessica J. Connelly · 2026 · Handbook of clinical neurology