Personalized Clinical Approaches to Anxiety Disorders
Abstract
Anxiety disorders (ADs) are common psychiatric disorders, with a lifetime prevalence estimated at 33.7% in epidemiological studies. ADs are associated with serious disability and severe impairment in quality of life. Although several treatments [e.g. selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), pregabalin, tricyclic antidepressants and benzodiazepines and/or cognitive-behaviour therapy (CBT)] are recommended, a large number of patients (i.e. from 30 to 70%) do not achieve complete remission. According to the novel paradigm of personalized medicine, the search of possible predictors of both disease vulnerability and treatment response might be the best way to prevent more accurately disease risk and to tailor the most effective treatment for each individual. Although a growing body of studies have proposed several endophenotypes/markers (i.e. neurochemical, neuroimaging, physiological, genetic and epigenetic endophenotypes/markers) as possible predictors of ADs susceptibility and/or treatment response, findings are not robust enough to be considered acceptable to incorporate in the clinical practice. In order to obtain more reliable results, larger studies with a multimodal approach, based on a combination of different biomarkers, are needed.
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There is currently no systematic process for the selection of anxiety treatments on the basis of empirically-supported markers of intervention success.
“There is currently no systematic process for the selection of anxiety treatments on the basis of empirically-supported markers of intervention success6.”
From Cluster-based psychological phenotyping and differences in anxiety treatment outcomes (2023) · cites this paper as [6]
To date, neuroimaging, genetic, and behavioral findings on anxiety disorders have not yet translated into robust and established markers of anxiety and its treatment outcomes to guide clinical recommendations.
“To date, neuroimaging, genetic, and behavioral findings on anxiety disorders have not yet translated into robust and established markers of anxiety and its treatment outcomes to guide clinical recommendations6.”
From Cluster-based psychological phenotyping and differences in anxiety treatment outcomes (2023) · cites this paper as [6]
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Candidate biomarkers in psychiatric disorders: state of the field
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Zhu, Y., Fu, Y., Han, J., Wang, R., Ma, X., Hu, X., Li, T., & Ma, Z. (2025) · Scientific Data · doi:10.1038/s41597-025-05449-z · Cited by 1 · see citing works
FEATURES OF ANXIETY AND DEPRESSIVE DISORDERS IN PATIENTS WITH FUNCTIONAL INTESTINAL DISORDERS
Kryvoruchko, I. G., Skrypnyk, І. М., Приходько, Н. П., Scherbak, О. В., & Yakimishina, L. I. (2021) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.21.4.43
The Use of Gamification in Social Phobia
Simões-Silva, V., Maravalhas, V., Cunha, A. R., Soares, M. I., & Marques, A. J. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-7589-8.ch060
Caldirola, D., Donatis, D. D., Alciati, A., Daccò, S., & Perna, G. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2254938
Self-citationEffects of metformin in an experimental chronic unpredictable mild stress model
Ozsagır, M. H., Polat, E. B., Kaya, Ö. T. Ç., Aykaç, A., & Özbeyli, D. (2026) · Journal of Research in Pharmacy · doi:10.12991/jrespharm.1690442
- Authors
- Perna, G., Alciati, A., Sangiorgio, E., Caldirola, D., & Nemeroff, C. B.
- Affiliations
- Humanitas University (IT)
- Hermanas Hospitalarias del Sagrado Corazón de Jesús (IT)
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Singapore
- Published
- 2020
- Volume
- 1191
- Pages
- 489-521
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W3003708317
- Cited by
- 15
- References
- 175
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3
- FWCI
- 13.85
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anxiety disorders, personalized medicine, biomarkers, endophenotypes, treatment response prediction, disease susceptibility, multimodal biomarkers, genetic biomarkers, epigenetic biomarkers, neuroimaging biomarkers, cognitive behavioral therapy, antidepressants
- MeSH terms
- Serotonin and Noradrenaline Reuptake Inhibitors, Anxiety Disorders, Humans, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors
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