Cited by 15Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Personalized Clinical Approaches to Anxiety Disorders

Perna, Giampaolo, Alciati, Alessandra, Sangiorgio, Erika, Caldirola, Daniela, Nemeroff, Charles B.·2020·Advances in Experimental Medicine and Biology

Abstract

Anxiety disorders (ADs) are common psychiatric disorders, with a lifetime prevalence estimated at 33.7% in epidemiological studies. ADs are associated with serious disability and severe impairment in quality of life. Although several treatments [e.g. selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), pregabalin, tricyclic antidepressants and benzodiazepines and/or cognitive-behaviour therapy (CBT)] are recommended, a large number of patients (i.e. from 30 to 70%) do not achieve complete remission. According to the novel paradigm of personalized medicine, the search of possible predictors of both disease vulnerability and treatment response might be the best way to prevent more accurately disease risk and to tailor the most effective treatment for each individual. Although a growing body of studies have proposed several endophenotypes/markers (i.e. neurochemical, neuroimaging, physiological, genetic and epigenetic endophenotypes/markers) as possible predictors of ADs susceptibility and/or treatment response, findings are not robust enough to be considered acceptable to incorporate in the clinical practice. In order to obtain more reliable results, larger studies with a multimodal approach, based on a combination of different biomarkers, are needed.

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Crossref · 10.1007/978-981-32-9705-0_25

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175 of 175 references verified0 citation errors · 0 not checkable

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  • There is currently no systematic process for the selection of anxiety treatments on the basis of empirically-supported markers of intervention success.

    “There is currently no systematic process for the selection of anxiety treatments on the basis of empirically-supported markers of intervention success6.”
  • To date, neuroimaging, genetic, and behavioral findings on anxiety disorders have not yet translated into robust and established markers of anxiety and its treatment outcomes to guide clinical recommendations.

    “To date, neuroimaging, genetic, and behavioral findings on anxiety disorders have not yet translated into robust and established markers of anxiety and its treatment outcomes to guide clinical recommendations6.”

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Authors
Perna, G., Alciati, A., Sangiorgio, E., Caldirola, D., & Nemeroff, C. B.
Affiliations
  • Humanitas University (IT)
  • Hermanas Hospitalarias del Sagrado Corazón de Jesús (IT)
Venue
Advances in Experimental Medicine and Biology
Published
2020
Volume
1191
Pages
489-521
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
OpenAlex
W3003708317
Cited by
15
References
175
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3
FWCI
13.85
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
anxiety disorders, personalized medicine, biomarkers, endophenotypes, treatment response prediction, disease susceptibility, multimodal biomarkers, genetic biomarkers, epigenetic biomarkers, neuroimaging biomarkers, cognitive behavioral therapy, antidepressants
MeSH terms
Serotonin and Noradrenaline Reuptake Inhibitors, Anxiety Disorders, Humans, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors

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