On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Cited by (377)

Items 301–377 of 377

  1. Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome
    Ethan Perkins, Christopher Cooper, Emma Lund, Miriam Alb, Hannah Morgan, Birgit Fogal, Philip G. Hewitt, Alexander Mazein, Marek Ostaszewski, Katherina Sewald · 2026 · Frontiers in Immunology
  2. A Planar Darkfield Illuminator for Wide‐Field High‐Contrast Imaging of Specimens in Microfluidic Chips
    Zetao Fan, Xiao Q. Yang, Xinxiang You, Ke Qiang Yang, Ling Zhu, Douguo Zhang · 2024 · Laser & Photonics Review
  3. Microvasculature-on-a-Chip: Bridging the interstitial blood-lymph interface via mechanobiological stimuli
    Barbara Bachmann, Sarah Spitz, Christian Jordan, Patrick Schuller, Heinz D. Wanzenböck, Bahram Haddadi, Michael Harasek, Heinz R. Redl, Wolfgang Holnthoner, Peter Ertl · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma
    Delta Ghoshal, Ingrid Petersen, Rachel Ringquist, Liana Kramer, Eshant Bhatia, Thomas Hu, Ariane Richard, Reda Park, Jenna Corbin, Savi Agarwal et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Cancer-metastasis-on-a-chip reveals efficacy of bevacizumab and siRNA in overcoming carboplatin resistance in SKOV3 ovarian cancer within a fibrotic metastatic microenvironment
    Sun‐Young Hwang, Danbi Lee, Yu-Gyeong Lee, Jungho Ahn, Youn‐Jung Kang · 2025 · Materials Today Bio
  6. Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling
    Ying-Yu Lin, Parker J. Esswein, Lucas P. Ramirez, Emily C. Warren, Julian Nicenboim, Sharon Gerecht · 2026 · Nature Biomedical Engineering
  7. A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip models
    Elizabeth Elton, Carly Strelez, Nolan M. Ung, Rachel G. Perez, Kimya Ghaffarian, Danielle Hixon, Naim Matasci, Shannon M. Mumenthaler · 2024 · SLAS DISCOVERY
  8. Investigation of tumour environments through advancements in microtechnology and nanotechnology
    Zhen Liu, Yan Liang Fan, Mengyao Cui, Xuming Wang, Pengfei Zhao · 2024 · Biomedicine & Pharmacotherapy
  9. Application of instant assembly of collagen to bioprint cardiac tissues
    Hugh Xiao, Zixie Liang, Xiangyu Gong, Seyma Nayir Jordan, Alejandro Rossello‐Martinez, Ilhan Gokhan, Xia Li, Zhang Wen, Sein Lee, Stuart G. Campbell et al. · 2025 · APL Bioengineering
  10. On-chip fabrication of tailored 3D hydrogel scaffolds to model cancer cell invasion and interaction with endothelial cells
    Federico Cantoni, Laurent Barbe, Ananya Roy, Grzegorz Wicher, Stina Simonsson, Karin Forsberg‐Nilsson, Maria Tenje · 2024 · APL Bioengineering
  11. A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis
    Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Cam Thai, Shania Dantes, David Allen Barbie, Sarah E. Shelton, Roger Dale Kamm · 2025 · Advanced Functional Materials
  12. Application of Organ-on-Chip in Blood Brain Barrier Model
    Pankhi Vatsa, Aditya Bhushan Pant · 2022 · Springer eBooks
  13. Blood vessels-on-a-chip
    Kae Sato, Kiichi Sato · 2023 · Elsevier eBooks
  14. Tissue-engineered 3D cancer microenvironment for screening therapeutics
    Nancy T. Li, Ileana L. Co, Natalie Landon‐Brace, Simon Latour, Alison P. McGuigan · 2020 · Elsevier eBooks
  15. Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2
    Jia He, Adriana Blazeski, Uthayanan Nilanthi, Javier Menéndez, Samuel C. Pirani, Daniel S. Levic, Michel Bagnat, Manvendra Kumar Singh, José G. Raya, Guillermo García‐Cardeña et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Label-free phenotyping of human microvessel networks
    Luca Rappez, Akinola Akinbote, Marta Cherubini, Virginie Uhlmann, Kristina Haase · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Label-free prediction of vascular connectivity in perfused microvascular networks in vitro
    Liang Xu, Pengwu Song, Shilu Zhu, Yang Zhang, Ru Zhang, Zhiyuan Zheng, Qingdong Zhang, Jie Gao, Han Chen, Mingzhai Sun et al. · 2025 · Computer Methods and Programs in Biomedicine
  18. ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity
    Sofia Morazzo, Soraia Fernandes, Marina Fortea, Helena Skálová, Daniel Pereira-Sousa, Marco Cassani, Kamila Vrzalová, Filip Kafka, Jan Vrbský, Mathilde Soulez et al. · 2025 · Frontiers in Oncology
  19. Microfluidic engineering of immune-competent organs-on-chips and their applications
    Xianwei Liang, Xiangyang Bu, Shuai Yuan, Chengjun Wu, Dongdong Liu, Jiu Deng · 2026 · Frontiers in Immunology
  20. Lessons and Insights From the First Microphysiological World Summit
    Nureddin A. Ashammakhi, Mustafa Nakipoğlu, Thomas Härtung · 2023 · Journal of Craniofacial Surgery Open
  21. Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vivo
    Keli Kuang, Xiang Chen, Maolin Wang, Weijing Han, Xue Qiu, Taoli Jin, Rong Xu, Bing Yuan, Meiqi Qian, Chunyan Li et al. · 2024 · Journal of Medicinal Chemistry
  22. Vascularized platforms for investigating cell communication via extracellular vesicles
    Junyoung Kim, Jooyoung Ro, Yoon‐Kyoung Cho · 2024 · Biomicrofluidics
  23. Microfluidic-based models to address the bone marrow metastatic niche complexity
    Patrícia Silva Santos Ribeiro, Luís Leitão, Ana Carolina Monteiro, Andrea Bortolin, Beatriz S. Moura, Meriem Lamghari, Estrela Neto · 2020 · Seminars in Cell and Developmental Biology
  24. Tumour-on-a-Chip: Perfusion Systems to Model the Extracellular Breast Tumour Microenvironment—From Tumour Progression to Metastasis Formation
    Annalisa Tirella · 2022 · Springer eBooks
  25. Biophysical model for high-throughput tumor and epithelial cell co-culture in complex biochemical microenvironments
    Guoqiang Li, Yanping Liu, Jingru Yao, Kena Song, Gao Wang, Lianjie Zhou, Guo Chen, Liyu Liu · 2021 · Chinese Physics B
  26. Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
    Cynthia Hajal · 2018 · DSpace@MIT (Massachusetts Institute of Technology)
  27. Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification
    Tae-Yun Kang, Federico Bocci, Qing Hua Nie, José N. Onuchic, Andre Levchenko · 2023 · eLife
  28. In Vitro and In Vivo Host Models of Metastasis
    Sam H. Au · 2023 · Current cancer research
  29. Insights into the efficacy and safety of CAR-T therapies using organoids and organs-on-chips
    Tong Wu, Danhong Wu, Hulie Zeng · 2026 · TrAC Trends in Analytical Chemistry
  30. A method for quantifying and automatic grading of musculoskeletal ultrasound superb microvascular imaging based on dynamic analysis of optical flow model
    Shanna Liu, Bo Shang, Junliang Yan, Zenghua Zhu, Yuanhao Ding, Qingli Zhou, Chengjing Wei, Yuqiang Shen, Xinjian Zhu · 2025 · Scientific Reports
  31. Extracellular matrix properties, interstitial flow, and VEGF gradients shape trophoblast behavior in a pumpless Trophoblast Invasion-on-Chip (TIoC)
    Ludivine Delon, Mathias Busek, Dilara Lal Lal, Renee Celine Heesakkers, Thea Josefine Wergeland, Justyna Stokowiec, Agata Socha, Thomas M. D. Combriat, Alexey Golovin, Yuliia Boichuk et al. · 2026 · Biomaterials
  32. Biofabrication and biomedical manufacturing research frontiers in the United States
    Yunxia Chen, Kyle R. Phillips, Eben Alsberg, Thomas E. Angelini, Nasim Annabi, Anthony Atala, Amit Kumar Bandyopadhyay, Leon M. Bellan, Luiz E. Bertassoni, Adriana Blazeski et al. · 2026 · Bio-Design and Manufacturing
  33. From flow to form: structuring and patterning hydrogels using microfluidic approaches
    Ella E. Bouker, Lauren G. Brown, Emilie Newsham Novak, Ariel Lin, Jamison M. Whitten, Asha R. Viswanathan, Laura A. Milton, M Yunos Alizai, Siwan Park, Jungseub Lee et al. · 2026 · Lab on a Chip
  34. Automatic feedback control by image processing for mixing solutions in a microfluidic device
    I. García, L. A. Martínez, A. Zanini, Dennis Raith, Joschka Boedecker, Matías Stingl, Betiana Lerner, Maximiliano Pérez, Roland H. Mertelsmann · 2022 · Biomicrofluidics
  35. Advanced microfluidic systems for the colorectal cancer diagnosis and its clinical application
    Vipul D. Prajapati, Princy Shrivastav, Salona D. Roy, Sonali Singh · 2024 · Elsevier eBooks
  36. Organs-on-a-chip in precision medicine
    Vikas Gupta, Ravinder Sharma, Renu Bansal, Gunpreet Kaur, Sanjiv Kumar, Parveen Bansal · 2024 · Elsevier eBooks
  37. Tissue chips as headway model and incitement technology
    Prerna Suchitan Modi, Abhishek Singh, Awyang Chaturvedi, Shailly Agarwal, Raghav Dutta, Ranu Nayak, Alok Singh · 2024 · Synthetic and Systems Biotechnology
  38. Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D
    Deborah J. Wessels, Claude Pujol, Nikash Pradhan, Daniel F. Lusche, Luis Gonzalez, Sydney E Kelly, Elizabeth M. Martin, Edward R. Voss, Yang‐Nim Park, Michael E. Dailey et al. · 2021 · Cell Adhesion & Migration
  39. Looking back, moving forward
    Miriel Ho, Mirabelle S. H. Ho, Clifford Lawrence Librach · 2021 · Elsevier eBooks
  40. Laser-based 3D printing using bessel beams for tissue engineering applications
    Andy Wen Loong Liew · 2020 · DR-NTU (Nanyang Technological University)
  41. Development of a bioengineered microvascular in vitro model
    Jordan W. Davern · 2020 · Queensland University of Technology
  42. A mammary-specific microfluidic device for studying post-radiotherapy vascular-immune cell interactions
    Shannon E. Martello, Sofia N. Luna, Katelyn Derr, Gladys Martinez Franco, Marissa Paul, Mark Mc Veigh, Leon M. Bellan, Marjan Rafat · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Long-term co-culture of endothelial and cancer cells within biomimetic microfluidic chips for investigating juxtacrine and paracrine regulatory signaling pathways
    Shirin Soleimani · 2019
  44. In vitro and in vivo technologies: an up to date overview in tissue engineering
    Roxana Cristina Popescu, Ecaterina Andronescu, Alexandru Mihai Grumezescu · 2019 · Elsevier eBooks
  45. Dissecting Effects of Anti-cancer Drugs and of Cancer-associated Fibroblasts by On-chip Reconstitution of Immunocompetent Tumor Microenvironments
    M. J. N'guyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet‐Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Philémon Sirven, Floriane Pelon et al. · 2018 · SSRN Electronic Journal
  46. Effects of Biomechanical and Biochemical Stimuli on Angio- and Vasculogenesis in a Complex Microvasculature-on-Chip
    Dario Ferrari, Arunima Sengupta, Johann Michler, László Pethő, Thomas Geiser, Soheila Zeinali, Olivier T. Guenat · 2022 · SSRN Electronic Journal
  47. Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification
    Tae-Yun Kang, Federico Bocci, Qing Hua Nie, José N. Onuchic, Andre Levchenko · 2024 · eLife
  48. Reviewer #2 (Public Review): Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
    2024 · eLife
  49. Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization
    Y Ikeda, Hiroko Oshima, Sau Yee Kok, Masanobu Oshima, Yukiko T. Matsunaga · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  50. UDP-6-glucose dehydrogenase in hormonally responsive breast cancers
    Meghan J. Price, Annee D. Nguyen, Corinne N. Haines, César D. Baëta, Jovita K. Byemerwa, Debarati Murkajee, Sandeep Artham, Vardhman Kumar, Catherine Lavau, Suzanne E. Wardell et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Drugs and cellular dynamics in tumor microenvironment using microphysiological systems
    Yuji Nashimoto · 2025 · Folia Pharmacologica Japonica
  52. Compartmentalized perfusion for temporal control of the chemical microenvironment of iPSC-derived cardiac cells
    Kaisa Tornberg, Wolfram Grötsch, Niina Ritari, Saara Haikka, Lassi Sukki, Katriina Aalto‐Setälä, Mari Pekkanen-Mattila, Pasi J. Kallio · 2025 · Lab on a Chip
  53. Numerical Modelling of Tumor Transport in Fluid Flows
    Meraj Ahmed, Tam Thien Nguyen, Lahcen Akerkouch, Margherita Tavasso, Ankur Bordoloi, Trung Bao Le · 2025 · Design of Medical Devices Conference (DMD)
  54. Non-Animal Technologies to Study and Target the Tumour Vasculature and Angiogenesis
    Elisabetta Ferrero, Jonas Hue, Marina Ferrarini, Lorenzo Veschini · 2025 · Organoids
  55. Angiogenesis gene signatures in patient-derived tumor spheroids for genetic and tumor angiogenesis profiling
    Sujin Hyung, Jihoon Ko, Minae An, Seung Tae Kim, Se Hoon Park, Jung Yong Hong, Sung Hee Lim, Kyoung‐Mee Kim, Jeeyun Lee · 2025 · Journal of Materials Chemistry B
  56. Tumor-on-a-Chip: From Biomimetic Tumor-Immune Microenvironments to Therapeutic Insights
    Yüksel Çetin · 2025 · Biochemistry
  57. The impacts of shape in lateral migration of cancer cells in a microchannel
    Meraj Ahmed, Lahcen Akerkouch, Amanda Haage, Trung Bao Le · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Additional file 1 of Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding
    Wan, Ho-Ying, Jack Chun Hin Chen, Qinru Xiao, Christy Wing Tung Wong, Yang, Boguang, Benjamin Cao, Rocky S. Tuan, Nilsson, Susan K., Ho, Yi-Ping, Michael Raghunath et al. · 2023 · Figshare
  59. Alternative Technologies for Animal Experiments Using Patient Tissue in Oncology Drug Discovery Research
    Katsuomi Ichikawa · 2025 · Drug Delivery System
  60. Development of a physiologically-relevant in-vitro microfluidic model for monitoring of pancreatic cancer cells interactions with the liver
    Mathieu Danoy · 2017
  61. Shedding lights on cancer cells and their microenvironment : development of 3D in vitro tumor models to shorten the translation of nanomedicines from the bench to the bedside
    Gianpiero Lazzari · 2018 · theses.fr (ABES)
  62. Potentiel thérapeutique d’un peptide antagoniste de l’interaction TSP-1 : CD47 dans la thrombose artérielle et sur les effets potentialisateurs des plaquettes dans la progression tumorale
    Thomas Sarazin · 2022 · theses.fr (ABES)
  63. Effect of blood flow-derived forces on human brain microvasculature in a 3D microvessel-on-chip.
    Clara Ramón-Lozano · 2023 · theses.fr (ABES)
  64. Microfluidic approach to Circulating Tumor Cells response to fast flow-induced deformations
    Emile Gasser · 2024 · theses.fr (ABES)
  65. Hypoxia-on-chip : from technological developments to biological applications
    Charlotte Bouquerel · 2023 · theses.fr (ABES)
  66. Décrypter le dialogue des cellules de tumeur du sein avec leur écosystème, après radio/chimiothérapie, en utilisant des technologies de bioimpression
    Théo Désigaux · 2024 · theses.fr (ABES)
  67. Targeting the cell cycle : A novel therapeutic strategy against ATIP3- deficient breast cancer
    Maria M. Haykal · 2023 · theses.fr (ABES)
  68. A microfluidic lung cancer-vascular tumor-on-a-chip model for precise evaluation of anti-invasion therapeutics
    Jinnuo Lu, Yixiao Huang, ShuJie Ma, Shoucheng Hu, Linhua Xuzhan, Yifan Huang, Bowen Wu, Zekai Hu, Chenyou Zhao, Jiayi Huang et al. · 2026 · Clinical and Experimental Medicine
  69. New insights in tumor-on-a-chip models for studying cancer drug resistance
    Yunbo Wang, Lin Shi, Jianqiao Li, Xiangrong Zhang, Jiabao Ren, Qian Jia, Litao Lv, Lijuan Yang, Zhengzheng Zhang, Jiankai Yang et al. · 2026 · Pathology - Research and Practice
  70. Modeling glioblastoma niche-by-niche: recent advancements in bioengineering of organotypic models of glioblastoma for precision medicine
    Kimia Abedi, Cheick A. Sissoko, Sirjana Pun, Sumedha Kappagantula, Beatrice Zucca, Riccardo Barrile · 2026 · Biofabrication
  71. Interfacial Morphology Shapes Endothelial Organization and Function in a Blood–Brain Barrier-on-a-Chip
    Qihang Yang, Z.T. Li, Zhijun Tan, Xueping Wang, Shiping Hao, Yuening He, Xiang Zhong, Jintao Li, Yufei Xue, Tingting Yu et al. · 2026 · ACS Applied Materials & Interfaces
  72. Involvement of vimentin intermediate filaments in overcoming tissue barriers during cancer cell dissemination
    Anna O. Zholudeva, E. A. Kozlova, Natalia A. Gloushankova, Antonina Y. Alexandrova · 2026 · Tissue Barriers
  73. Oxygen-enhanced assembloid-based vascularized intestinal-on-a-chip for radioprotective drug evaluation
    Yuting Guo, Meiling Fu, Yuan Pang · 2026 · Frontiers in Toxicology
  74. A novel in vitro assay for quantifying endothelial cell and pericyte interactions
    David J. Csordas, Lily C Cucuzzella, John S. Kim, Shayn M. Peirce · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  75. In situ monitoring of perfusable vascular network formation and development in an electrochemical microfluidic chip
    Hang Qi, Zelin Li, Yilan Yang, Shuaihua Zhang, Quanning Li, Xuejiao Chen, Yanyan Wang · 2026 · Biosensors and Bioelectronics
  76. Impacts of Morphology and Elasticity on Cancer Cell Deformation in Shear Flows
    Meraj Ahmed, Lahcen Akerkouch, Aaron Vanyo, Amanda Haage, Trung Bao Le · 2026 · Annals of Biomedical Engineering
  77. A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization
    Emily C. Warren, Alex Wu, Lucas P. Ramirez, Yaqing Huang, Connor D. Amelung, Sophia Saxonhouse, Sharon Gerecht · 2026 · Advanced Materials