The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Gap junctions and cancer: communicating for 50 years
Open accessAbstract
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some tumour types, they may facilitate specific stages of tumour progression through both junctional and non-junctional signalling pathways. This Timeline article highlights the milestones connecting gap junctions to cancer, and underscores important unanswered questions, controversies and therapeutic opportunities in the field.
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Cites
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,323
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
Hidalgo, M., Amant, F., Biankin, A. V., Budinská, E., Byrne, A. T., Caldas, C., Clarke, R. B., de Jong, S., Jonkers, J., Mælandsmo, G. M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0001 · Cited by 1,742
HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER
Revel, J. P., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.33.3.c7 · Cited by 1,488
Cardiac Malformation in Neonatal Mice Lacking Connexin43
Reaume, A. G., de Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,244
Brain tumour cells interconnect to a functional and resistant network
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Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Self-citationConnexin43: a protein from rat heart homologous to a gap junction protein from liver.
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Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease
Bergoffen, J., Scherer, S. S., Wang, S., Scott, M. O., Bone, L. J., Paul, D. L., Chen, K., Lensch, M. W., Chance, P. F., & Fischbeck, K. H. (1993) · Science · doi:10.1126/science.8266101 · Cited by 1,066
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E. E., Lopez-Soto, A., S. Jacob, L., Patwa, R., Shah, H., Xu, K., et al. (2016) · Nature · doi:10.1038/nature18268 · Cited by 969
Metadata
- Authors
- Aasen, T., Mesnil, M., Naus, C. C., Lampe, P. D., & Laird, D. W.
- Venue
- Nature Reviews Cancer
- Published
- 2016-10-21
- Volume
- 16
- Issue
- 12
- Pages
- 775-788
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2538136738
- Cited by
- 369
- References
- 171
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Aasen, T., Mesnil, M., Naus, C. C., Lampe, P. D., & Laird, D. W. (2016). Gap junctions and cancer: communicating for 50 years. Nature Reviews Cancer. https://doi.org/10.1038/nrc.2016.105
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
