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A fate worse than death: apoptosis as an oncogenic process
Abstract
Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.
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Metadata
- Authors
- Ichim, G., & Tait, S. W. G.
- Affiliations
- Cancer Research UK Scotland Institute (GB)
- Corresponding author
- Tait, Stephen W. G.
- Venue
- Nature Reviews Cancer
- Published
- 2016-07-01
- Volume
- 16
- Issue
- 8
- Pages
- 539-548
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2474601761
- Cited by
- 451
- References
- 158
- Citations by year
- 2026: 21 · 2025: 33 · 2024: 35 · 2023: 37 · 2022: 43 · 2021: 49 · 2020: 68 · 2019: 59 · 2018: 56 · 2017: 40 · 2016: 7
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- Cancer Research UK (20145)
- Biotechnology and Biological Sciences Research Council (BB/K008374/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- apoptosis, cancer, tumor suppression, tumor promotion, cancer therapy
- MeSH terms
- Animals, Humans, Neoplasms, Oncogenes, Prognosis, Apoptosis, Carcinogenesis
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