Cited by 451Cell death mechanisms and regulationPhagocytosis and Immune RegulationCancer-related Molecular Pathways

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A fate worse than death: apoptosis as an oncogenic process

Ichim, Gabriel, Tait, Stephen W. G.·2016·Nature Reviews Cancer

DOI 10.1038/nrc.2016.58

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Abstract

Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.

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Authors: Ichim, G., & Tait, S. W. G.
Affiliations: Cancer Research UK Scotland Institute (GB)
Corresponding author: Tait, Stephen W. G.
ORCID: Ichim, Gabriel
Tait, Stephen W. G.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2016-07-01
Volume: 16
Issue: 8
Pages: 539-548
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc.2016.58
OpenAlex: W2474601761
Cited by: 451
References: 158
Citations by year: 2026: 21 · 2025: 33 · 2024: 35 · 2023: 37 · 2022: 43 · 2021: 49 · 2020: 68 · 2019: 59 · 2018: 56 · 2017: 40 · 2016: 7
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders: Cancer Research UK (20145)
Biotechnology and Biological Sciences Research Council (BB/K008374/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: apoptosis, cancer, tumor suppression, tumor promotion, cancer therapy
MeSH terms: Animals, Humans, Neoplasms, Oncogenes, Prognosis, Apoptosis, Carcinogenesis

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A fate worse than death: apoptosis as an oncogenic process

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