The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Pancreatic cancer biology and genetics from an evolutionary perspective
Open accessAbstract
Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma (hereafter referred to as pancreatic cancer) is a particularly robust example of this phenomenon. Genomic features indicate that pancreatic cancer cells are selected for fitness advantages when encountering the geographic and resource-depleted constraints of the microenvironment. Phenotypic adaptations to these pressures help disseminated cells to survive in secondary sites, a major clinical problem for patients with this disease. In this Review we gather the wide-ranging aspects of pancreatic cancer research into a single concept rooted in Darwinian evolution, with the goal of identifying novel insights and opportunities for study.
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Cites
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Tumors: Wounds That Do Not Heal
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Cited by
Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321
Metabolic Interactions in the Tumor Microenvironment
Lyssiotis, C. A., & Kimmelman, A. C. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.06.003 · Cited by 853
“This leads to changes in signal transduction, the epigenome, and gene expression, which endow a spectrum of differentiation, metabolic, and proliferative states across the cancer cell populations in the tumor [2, 3].”
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Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3764 · Cited by 403
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Storz, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.12 · Cited by 389
Metadata
- Authors
- Makohon-Moore, A., & Iacobuzio-Donahue, C. A.
- Venue
- Nature Reviews Cancer
- Published
- 2016-07-22
- Volume
- 16
- Issue
- 9
- Pages
- 553-565
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2491220498
- Cited by
- 431
- References
- 40
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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