Cited by 3,559Angiogenesis and VEGF in CancerCancer Cells and MetastasisMathematical Biology Tumor Growth

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Tumorigenesis and the angiogenic switch

Bergers, Gabriele, Benjamin, Laura E.·2003·Nature reviews. Cancer

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Abstract

It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies-- not only for cancer treatment, but also for preventing recurrence.

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Authors: Bergers, G., & Benjamin, L. E.
Affiliations: University of California, San Francisco (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Bergers, Gabriele
ORCID: Bergers, Gabriele
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2003-06
Volume: 3
Issue: 6
Pages: 401-410
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1093
OpenAlex: W2804842145
Cited by: 3,559
References: 110
Citations by year: 2026: 53 · 2025: 79 · 2024: 123 · 2023: 122 · 2022: 142 · 2021: 160 · 2020: 149 · 2019: 159 · 2018: 162 · 2017: 176 · 2016: 148 · 2015: 176 · 2014: 232 · 2013: 223 · 2012: 198
FWCI: 9.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
Keywords: carcinogenesis, angiogenic switch, tumor angiogenesis, tumor vasculature, tumor microenvironment, tumor-stroma interactions, tumor progression, anti-angiogenic therapy, tumor recurrence
MeSH terms: Animals, Humans, Neoplasms, Neovascularization, Pathologic, Disease Progression

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Tumorigenesis and the angiogenic switch

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