The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Tumorigenesis and the angiogenic switch
Abstract
It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies-- not only for cancer treatment, but also for preventing recurrence.
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In the citing paper
“This neovascularization represents a rate-limiting step in tumor progression [47].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [47]
In the citing paper
“Instead of triggering angiogenesis, some tumors co-opt existing vasculature and grow along the vessels [53][54][55][56], until the demand for nutrients and oxygen becomes too large and angiogenesis starts again [53,55].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [55]
Citations
Cites
1 retracted
Watnick, R. S., Cheng, Y.-N., Rangarajan, A., Ince, T. A., & Weinberg, R. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00030-8 · Cited by 318
RetractedHanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Genetic Alterations during Colorectal-Tumor Development
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Mechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,235
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
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Research works printed but not linked: 2
- Folkman, J. in Cancer Medicine (Holland, M.D. et al.) 2546 (BC Decker, Hamilton, Ontario, 2000).
- Sternlicht, M. D. et al. Matrix proteinases as emerging targets in anticancer therapy: status and prospects. ETT 4, 609–633 (2000).
Cited by
Sorted by citations
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Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer
Tummers, W. S., Willmann, J. K., Bonsing, B. A., Vahrmeijer, A. L., Gambhir, S. S., & Swijnenburg, R.-J. (2018) · Pancreas · doi:10.1097/mpa.0000000000001075 · Cited by 50
Involvement of RB gene family in tumor angiogenesis
Gabellini, C., Del Bufalo, D., & Zupi, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209631 · Cited by 47
Ozbudak, I. H., Karaveli, S., Simsek, T., Erdogan, G., & Pestereli, E. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.11.028 · Cited by 46
Targeting the stromal microenvironment in chronic inflammation
FILER, A., PITZALIS, C., & BUCKLEY, C. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.03.007 · Cited by 45
Crosstalk between nitric oxide and hypoxia-inducible factor signaling pathways: an update
Poyton, R., & Hendrickson, M. (2015) · Research and Reports in Biochemistry · doi:10.2147/rrbc.s58280 · Cited by 45
García-Sánchez, D., González-González, A., Alfonso-Fernández, A., Del Dujo-Gutiérrez, M., & Pérez-Campo, F. M. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i5.421 · Cited by 32
Naik, E., O'Reilly, L. A., Asselin-Labat, M.-L., Merino, D., Lin, A., Cook, M., Coultas, L., Bouillet, P., Adams, J. M., & Strasser, A. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20100951 · Cited by 31
Bennouna, J., Deslandres, M., Senellart, H., de Labareyre, C., Ruiz-Soto, R., Wixon, C., Botbyl, J., Suttle, A. B., & Delord, J.-P. (2015) · Investigational New Drugs · doi:10.1007/s10637-014-0142-1 · Cited by 26
Gao, J., Li, F., Liu, Z., Huang, M., Chen, H., Liao, G., Meng, J., Wang, Q., Zhao, H., Li, C., et al. (2021) · Medicine · doi:10.1097/md.0000000000027130 · Cited by 6
Targeted therapy for non-small cell lung cancer: current standards and the promise of the future.
(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2014.05.01 · Cited by 716
Metadata
- Authors
- Bergers, G., & Benjamin, L. E.
- Affiliations
- University of California, San Francisco (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Bergers, Gabriele
- ORCID
- Bergers, Gabriele
- Venue
- Nature reviews. Cancer
- Published
- 2003-06
- Volume
- 3
- Issue
- 6
- Pages
- 401-410
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2804842145
- Cited by
- 3,559
- References
- 110
- Citations by year
- 2026: 53 · 2025: 79 · 2024: 123 · 2023: 122 · 2022: 142 · 2021: 160 · 2020: 149 · 2019: 159 · 2018: 162 · 2017: 176 · 2016: 148 · 2015: 176 · 2014: 232 · 2013: 223 · 2012: 198
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- carcinogenesis, angiogenic switch, tumor angiogenesis, tumor vasculature, tumor microenvironment, tumor-stroma interactions, tumor progression, anti-angiogenic therapy, tumor recurrence
- MeSH terms
- Animals, Humans, Neoplasms, Neovascularization, Pathologic, Disease Progression
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