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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
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“Increased circulating insulin has a number of indirect effects including a reduction in the hepatic synthesis and blood levels of sex hormone binding globulin, leading to increases in bioavailable estrogen in both men and women and increased levels of bioavailable testosterone in women but not in men (65).”
From Diabetes and Cancer (2010) · cites this paper as [65]
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“Increased circulating insulin has a number of indirect effects including a reduction in the hepatic synthesis and blood levels of sex hormone binding globulin, leading to increases in bioavailable estrogen in both men and women and increased levels of bioavailable testosterone in women but not in men (65).”
From Diabetes and Cancer (2010) · cites this paper as [65]
In the citing paper
“Increased circulating insulin has a number of indirect effects including a reduction in the hepatic synthesis and blood levels of sex hormone binding globulin, leading to increases in bioavailable estrogen in both men and women and increased levels of bioavailable testosterone in women but not in men (65).”
From Diabetes and Cancer (2010) · cites this paper as [65]
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- Seidell, J. & Rissanen, A. in Handbook of Obesity: Etiology and Pathophysiology (eds. Bray, G. & Bouchard, C.) 93–107 (Marcel Dekker, New York, 2004).
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Metadata
- Authors
- Calle, E. E., & Kaaks, R.
- Affiliations
- American Cancer Society (US)
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Calle, Eugenia E.
- Venue
- Nature reviews. Cancer
- Published
- 2004-08
- Volume
- 4
- Issue
- 8
- Pages
- 579-591
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1978281808
- Cited by
- 3,613
- References
- 216
- Citations by year
- 2026: 93 · 2025: 95 · 2024: 113 · 2023: 153 · 2022: 159 · 2021: 176 · 2020: 236 · 2019: 159 · 2018: 189 · 2017: 238 · 2016: 212 · 2015: 233 · 2014: 230 · 2013: 253 · 2012: 208
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- obesity, overweight, cancer risk, carcinogenesis, insulin resistance, hyperinsulinemia, inflammation
- MeSH terms
- Biological Availability, Humans, Hyperinsulinism, Inflammation, Insulin Resistance, Neoplasms, Obesity, Public Health, Gonadal Steroid Hormones, Epidemiologic Studies
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