Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154

Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report

(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696

Physical Status: The Use and Interpretation of Anthropometry

Frisancho, A. R. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.830 · Cited by 6,569

Prevalence and trends in obesity among US adults, 1999–2000

Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866

Actual causes of death in the United States

McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480

Actual Causes of Death in the United States, 2000

Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211

Banting lecture 1988. Role of insulin resistance in human disease.

Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

Lagergren, J., Bergström, R., Lindgren, A., & Nyrén, O. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903183401101 · Cited by 3,012

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer

Calle, E. E., Heath Jr., C. W., Coates, R. J., Liff, J. M., Franceschi, S., Talamini, R., Chantarakul, N., Koetsawang, S., Rachawat, D., Morabia, A., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)08233-0 · Cited by 2,450

Global strategy on diet, physical activity and health

Samuelson, G. (2004) · Food & Nutrition Research · doi:10.3402/fnr.v48i2.1503 · Cited by 2,318

Obesity and the Environment: Where Do We Go from Here?

Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180

Changing patterns in the incidence of esophageal and gastric carcinoma in the United States

Devesa, S. S., Blot, W. J., & Fraumeni, J. F. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 2,097

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

Chan, J. M., Stampfer, M. J., Giovannucci, E. L., Gann, P. H., Ma, J., Wilkinson, P., Hennekens, C. H., & Pollak, M. (1998) · Science · doi:10.1126/science.279.5350.563 · Cited by 1,992

American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity

Kushi, L. H., Byers, T., Doyle, C., Bandera, E. V., McCullough, M., Gansler, T., Andrews, K. S., Thun, M. J., & The American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.5.254 · Cited by 1,901

Annual Deaths Attributable to Obesity in the United States

Allison, D. B. (1999) · JAMA · doi:10.1001/jama.282.16.1530 · Cited by 1,863

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822

Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies

The Endogenous Hormones and Breast Cancer Collaborative Group (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.8.606 · Cited by 1,799

Use and misuse of population attributable fractions

Rockhill, B., Newman, B., & Weinberg, C. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.1.15 · Cited by 1,683

Nutritional Regulation of the Insulin-Like Growth Factors*

Thissen, J., Ketelslegers, J., & Underwood, L. E. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-80 · Cited by 1,575

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,292

Pathophysiology of insulin resistance in human disease

Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,226

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,204

The worldwide obesity epidemic

James, P. T., Leach, R., Kalamara, E., & Shayeghi, M. (2001) · Obesity Research · doi:10.1038/oby.2001.123 · Cited by 1,201

Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. Writing Group for the Women's Health Initiative Investigators. JAMA 2002; 288(3): 321-333

Gebbie, A. E. (2002) · Journal of Family Planning and Reproductive Health Care · doi:10.1783/147118902101196685 · Cited by 1,176

Variations in mortality by weight among 750,000 men and women

Lew, E. A., & Garfinkel, L. (1979) · Journal of Chronic Diseases · doi:10.1016/0021-9681(79)90119-x · Cited by 1,169

The insulin-like growth factor system and cancer

LeRoith, D., & Roberts, C. T. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00159-9 · Cited by 1,124

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.620 · Cited by 1,118

Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women

Endogenous Hormones Breast Cancer Collaborative Group (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg022 · Cited by 1,093

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk

Schairer, C. (2000) · JAMA · doi:10.1001/jama.283.4.485 · Cited by 1,046

Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.

Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002) · PubMed · Cited by 1,038

Physical Activity, Obesity, and Risk for Colon Cancer and Adenoma in Men

Giovannucci, E. L., Ascherio, A., Rimm, E. B., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-5-199503010-00002 · Cited by 1,011

The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs

Sturm, R. (2002) · Health Affairs · doi:10.1377/hlthaff.21.2.245 · Cited by 990

Dual Effects of Weight and Weight Gain on Breast Cancer Risk

Huang, Z., Hankinson, S. E., Colditz, G. A., Stampfer, M. J., Hunter, D. J., Manson, J. E., Hennekens, C. H., ROSNER, B. A., Speizer, F. E., & Willett, W. C. (1997) · JAMA · doi:10.1001/jama.1997.03550170037029 · Cited by 948

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854

The Insulin-Related Ovarian Regulatory System in Health and Disease

Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 852

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

Khandwala, H. M., McCutcheon, I. E., Flyvbjerg, A., & Friend, K. E. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.3.0399 · Cited by 842

Insulin and colon cancer

Giovannucci, E. L. (1995) · Cancer Causes & Control · doi:10.1007/bf00052777 · Cited by 808

Insulin Resistance — Mechanisms, Syndromes, and Implications

Epstein, F. H., Moller, D. E., & Flier, J. S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251307 · Cited by 807

Hormonal Etiology of Epithelial Ovarian Cancer, With a Hypothesis Concerning the Role of Androgens and Progesterone

Risch, H. A. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.23.1774 · Cited by 771

Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

Everhart, J. (1995) · JAMA · doi:10.1001/jama.273.20.1605 · Cited by 747

IARC Handbooks of Cancer Prevention

Feig, S. A. (2003) · Cancer · doi:10.1002/cncr.11334 · Cited by 745

Criteria for definition of overweight in transition: background and recommendations for the United States

Kuczmarski, R. J., & Flegal, K. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1074 · Cited by 705

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer

Michaud, D. S. (2001) · JAMA · doi:10.1001/jama.286.8.921 · Cited by 678

Obesity, Hypertension, and the Risk of Kidney Cancer in Men

Chow, W., Gridley, G., Fraumeni, J. F., & Järvholm, B. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011023431804 · Cited by 667

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

Kaaks, R. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.19.1592 · Cited by 655

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

Bergman, R. N., & Ader, M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00323-4 · Cited by 627

Cancer Incidence in a Population-Based Cohort of Patients Hospitalized With Diabetes Mellitus in Denmark

Wideroff, L., Gridley, G., Chow, W. H., Linet, M., Mellemkjaer, L., Olsen, J. H., Keehn, S., & Borch-Johnsen, K. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.18.1360 · Cited by 627

Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia

Chow, W., Blot, W. J., Vaughan, T. L., Risch, H. A., Gammon, M. D., Stanford, J. L., Dubrow, R., Schoenberg, J. B., Mayne, S. T., Farrow, D. C., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.2.150 · Cited by 622

Weight Loss in Breast Cancer Patient Management

Chlebowski, R. T., Aiello, E. J., & McTiernan, A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.4.1128 · Cited by 618

Exercise and Insulin Sensitivity: A Review

Borghouts, L. B., & KEIZER, H. A. (2000) · International Journal of Sports Medicine · doi:10.1055/s-2000-8847 · Cited by 617

Energy balance and cancer: the role of insulin and insulin-like growth factor-I

Kaaks, R., & Lukanova, A. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200070 · Cited by 610

Screening and Interventions for Obesity in Adults: Summary of the Evidence for the U.S. Preventive Services Task Force

McTigue, K. M., Harris, R., Hemphill, B., Lux, L. J., Sutton, S. F., Bunton, A. J., & Lohr, K. N. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00013 · Cited by 599

A prospective study of obesity and cancer risk (Sweden)

Wolk, A., Gridley, G., Svensson, M., Nyrén, O., McLaughlin, J. K., Fraumeni, J. F., & Adami, H.-O. (2001) · Cancer Causes & Control · doi:10.1023/a:1008995217664 · Cited by 581

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575

The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk

Key, T., & Pike, M. C. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.44 · Cited by 550

Invited Review: Effects of acute exercise and exercise training on insulin resistance

Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535

Resistin and obesity-associated insulin resistance

Steppan, C. M., & Lazar, M. A. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00522-7 · Cited by 528

State‐Level Estimates of Annual Medical Expenditures Attributable to Obesity*

Finkelstein, E. A., Fiebelkorn, I. C., & Wang, G. (2004) · Obesity Research · doi:10.1038/oby.2004.4 · Cited by 520

Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.

Vaughan, T. L., Davis, S., Kristal, A. R., & Thomas, D. B. (1995) · PubMed · Cited by 516

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

EHRMAN, D. A., Barnes, R. B., & Rosenfield, R. L. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-322 · Cited by 498

Diet, Body Size, and Breast Cancer

Hunter, D. J., & Willett, W. C. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036096 · Cited by 493

Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer

Schoen, R. E., Tangen, C. M., Kuller, L. H., Burke, G. L., Cushman, M., Tracy, R. P., Dobs, A. S., & Savage, P. J. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.13.1147 · Cited by 492

A global response to a global problem: the epidemic of overnutrition.

Chopra, M., Galbraith, S., & Darnton‐Hill, I. (2002) · Europe PMC (PubMed Central) · Cited by 472

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

McKeown‐Eyssen, G. (1994) · PubMed · Cited by 460

Age Changes in Body Composition Revealed by Computed Tomography

Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., & Silbert, C. K. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.6.673 · Cited by 460

Obesity and cancer risk: a danish record-linkage study

Møller, H., Mellemgaard, A., Lindvig, K., & Olsen, J. H. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)90254-2 · Cited by 449

Obesity and Estrogen as Risk Factors for Gastroesophageal Reflux Symptoms

Nilsson, M., Johnsen, R., Ye, W., Hveem, K., & Lagergren, J. (2003) · JAMA · doi:10.1001/jama.290.1.66 · Cited by 446

Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

Holmes, M. D., Pollak, M., Willett, W. C., & Hankinson, S. E. (2002) · PubMed · Cited by 435

Abnormal Glucose Metabolism and Pancreatic Cancer Mortality

Gapstur, S. M. (2000) · JAMA · doi:10.1001/jama.283.19.2552 · Cited by 420

Nutrition and Survival After the Diagnosis of Breast Cancer: A Review of the Evidence

Rock, C. L., & Demark‐Wahnefried, W. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.03.008 · Cited by 408

Body Size and Prostate Cancer: A 20-Year Follow-up Study Among 135006 Swedish Construction Workers

Andersson, S.-O., Wolk, A., Bergström, R., Adami, H., Engholm, G., Englund, A., & Nyrén, O. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.5.385 · Cited by 406

Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study

Stattin, P. E. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1910 · Cited by 406

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

Giovannucci, E. L., Pollak, M., Platz, E. A., Willett, W. C., Stampfer, M. J., Majeed, N., Colditz, G. A., Speizer, F. E., & Hankinson, S. E. (2000) · PubMed · Cited by 401

Role of insulin-like growth factor binding proteins in controlling IGF actions

Clemmons, D. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00024-0 · Cited by 396

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion

Ehrmann, D. A. (1995) · Endocrine Reviews · doi:10.1210/er.16.3.322 · Cited by 394

Central obesity and breast cancer risk: a systematic review

Harvie, M., Hooper, L., & Howell, A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00108.x · Cited by 392

Pathologic Variables and Recurrence Rates As Related to Obesity and Race in Men With Prostate Cancer Undergoing Radical Prostatectomy

Amling, C. L., Riffenburgh, R. H., Sun, L. L., Moul, J. W., Lance, R. S., Kusuda, L., Sexton, W. J., Soderdahl, D. W., Donahue, T. F., Foley, J. P., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.132 · Cited by 386

Impact of Obesity on Biochemical Control After Radical Prostatectomy for Clinically Localized Prostate Cancer: A Report by the Shared Equal Access Regional Cancer Hospital Database Study Group

Freedland, S. J., Aronson, W. J., Kane, C. J., Presti, J. C., Amling, C. L., Elashoff, D. A., & Terris, M. K. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.181 · Cited by 385

The Relation of Gastroesophageal Reflux Disease and Its Treatment to Adenocarcinomas of the Esophagus and Gastric Cardia

Chow, W.-H. (1995) · JAMA · doi:10.1001/jama.1995.03530060048032 · Cited by 376

A meta-analysis of obesity and the risk of pancreatic cancer

de González, A. B., Sweetland, S., & Spencer, E. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601140 · Cited by 363

Insulin resistance and breast‐cancer risk

Bruning, P. F., Bonfrèr, J. M. G., van Noord, P. A. H., Hart, A. A. M., Jong‐Bakker, M. D., & Nooijen, W. J. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520402 · Cited by 360

Estrogen Replacement Therapy and Risk of Fatal Colon Cancer in a Prospective Cohort of Postmenopausal Women

Calle, E. E., Miracle-McMahill, H. L., Thun, M. J., & Heath, C. W. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.7.517 · Cited by 360

Fasting glucose is a risk factor for breast cancer: a prospective study.

Muti, P. C., Quattrin, T., Grant, B. J. B., Krogh, V., Micheli, A., Schünemann, H. J., Ram, M., Freudenheim, J. L., Sieri, S., Trevisan, M., et al. (2002) · PubMed · Cited by 358

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

Tannenbaum, G. S., Guyda, H. J., & Posner, B. I. (1983) · Science · doi:10.1126/science.6338593 · Cited by 355

Nutrition, hormones, and breast cancer: Is insulin the missing link?

Kaaks, R. (1996) · Cancer Causes & Control · doi:10.1007/bf00051703 · Cited by 354

Recent Advances in Our Understanding of Insulin Action and Insulin Resistance

Roith, D. L., & Zick, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.588 · Cited by 347

Association of Obesity and Cancer Risk in Canada

Pan, S. Y. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh041 · Cited by 339

American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity

Byers, T., Nestle, M., McTiernan, A., Doyle, C., Currie-Williams, A., Gansler, T., & Thun, M. (2002) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.2.92 · Cited by 336

INCREASED INCIDENCE OF CARCINOMA OF THE BREAST ASSOCIATED WITH ABDOMINAL ADIPOSITY IN POSTMENOPAUSAL WOMEN

FOLSOM, A. R., Kaye, S. A., Prineas, R. J., Potter, J. D., Gapstur, S. M., & Wallace, R. B. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115570 · Cited by 331

Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States.

Rodríguez, C., Patel, A. V., Calle, E. E., Jacobs, E. J., Chao, A., & Thun, M. J. (2001) · PubMed · Cited by 326

Obesity and colon cancer: Does leptin provide a link?

Stattin, P. E., Lukanova, A., Biessy, C., Söderberg, S., Palmqvist, R., Kaaks, R., Olsson, T., & Jellum, E. (2003) · International Journal of Cancer · doi:10.1002/ijc.11668 · Cited by 323

Obesity and cancer risk among white and black United States veterans

Samanic, C. M., Gridley, G., Chow, W., Lubin, J. H., Hoover, R. N., & Fraumeni, J. F. (2004) · Cancer Causes & Control · doi:10.1023/b:caco.0000016573.79453.ba · Cited by 318

Obesity and renal cell cancer – a quantitative review

Bergström, A., Hsieh, C.-C., Lindblad, P., Lu, C., Cook, N. R., & Wolk, A. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2040 · Cited by 316

Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis

Bosland, M. C. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024244 · Cited by 309

Hepatic steatosis in obese patients: clinical aspects and prognostic significance

Festi, D., Colecchia, A., Sacco, T., Bondi, M., Roda, E., & Marchesini, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00126.x · Cited by 308

Insulin and related factors in premenopausal breast cancer risk

Giudice, M. E. D., Fantus, I. G., Ezzat, S., McKeown‐Eyssen, G., Page, D. L., & Goodwin, P. J. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005831013718 · Cited by 303

Screening for Cervical and Breast Cancer: Is Obesity an Unrecognized Barrier to Preventive Care?

Wee, C. C., McCarthy, E. P., Davis, R. B., & Phillips, R. S. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-9-200005020-00003 · Cited by 299

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States)

Wu, A. H., Wan, P. C., & Bernstein, L. (2001) · Cancer Causes & Control · doi:10.1023/a:1011290704728 · Cited by 297

Dietary fat, fatty acid composition in plasma and the metabolic syndrome

Vessby, B. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200302000-00004 · Cited by 291

Epidemiologic Aspects of Gallbladder Cancer: A Case-Control Study of the SEARCH Program of the International Agency for Research on Cancer

Zatoński, W. A., Przewozniak, K., Lowenfels, A. B., Boyle, P., Maisonneuve, P., Bueno-de-Mesquita, H. B., Moerman, C. J., Ghadirian, P., Simard, A., Jain, M., et al. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.15.1132 · Cited by 287

Physical activity, obesity, and risk of colorectal adenoma in women (United States)

Giovannucci, E. L., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1996) · Cancer Causes & Control · doi:10.1007/bf00051301 · Cited by 282

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

Robinson, S., Kiddy, D. S., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., Johnston, D. G., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02376.x · Cited by 282

Height, body weight, and risk of prostate cancer.

Giovannucci, E. L., Rimm, E. B., Stampfer, M. J., Colditz, G. A., & Willett, W. C. (1997) · PubMed · Cited by 282

Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden

Palmqvist, R., Hallmans, G., Rinaldi, S., Biessy, C., Stenling, R., Riboli, E., & Kaaks, R. (2002) · Gut · doi:10.1136/gut.50.5.642 · Cited by 280

Molecular mechanisms of insulin resistance and the role of the adipocyte

Hotamışlıgil, G. S. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801497 · Cited by 273

Reflux, Barrett's oesophagus and adenocarcinoma: burning questions

Wild, C. P., & Hardie, L. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1166 · Cited by 265

Dietary and Nutritional Factors and Pancreatic Cancer: a Case-Control Study Based on Direct Interviews

Silverman, D. T., Swanson, C. A., Gridley, G., Wacholder, S., Brown, L. M., Hayes, R. B., Fraumeni, J. F., Hoover, R. N., Pottern, L. M., Greenberg, R. S., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.22.1710 · Cited by 262

Breast Cancer and Obesity: An Update

Stephenson, G. D., & Rose, D. P. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4501_1 · Cited by 258

A Population-Based Case-Control Study of Renal Cell Carcinoma

McLaughlin, J. K., Mandel, J. S., Blot, W. J., Schuman, L. M., Mehl, E. S., & Fraumeni, J. F. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.2.275 · Cited by 249

Re: Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

Thomas, H. V., Key, T. J., Allen, D. S., Moore, J. W., Dowsett, M., Fentiman, I. S., & Wang, D. Y. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.5.396 · Cited by 246

Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Obesity in Men and Women

Tchernof, A., & Despres, J. (2000) · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · doi:10.1055/s-2007-978681 · Cited by 244

Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women

Lukanova, A., Lundin, E., Micheli, A., Arslan, A. A., Ferrari, P., Rinaldi, S., Krogh, V., Lenner, P., Shore, R. E., Biessy, C., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11529 · Cited by 239

Obesity

Björntorp, P. A. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04503-0 · Cited by 234

Progress in obesity research: 7

Angel, A. (1996) · Medical Entomology and Zoology · Cited by 232

Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women

Petrelli, J. M., Calle, E. E., Rodríguez, C., & Thun, M. J. (2002) · Cancer Causes & Control · doi:10.1023/a:1015288615472 · Cited by 228

No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study

Lagergren, J., Bergström, R., & Nyrén, O. (2000) · Gut · doi:10.1136/gut.47.1.26 · Cited by 224

The role of diabetes mellitus in the aetiology of renal cell cancer

Lindblad, P., Chow, W. H., Chan, J., Bergström, A., Wolk, A., Gridley, G., McLaughlin, J. K., Nyrén, O., & Adami, H. O. (1999) · Diabetologia · doi:10.1007/s001250051122 · Cited by 220

Height, body mass index, and prostate cancer: a follow-up of 950 000 Norwegian men

Engeland, A., Tretli, S., & Bjørge, T. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601206 · Cited by 219

Reversal of Relation Between Body Mass and Endogenous Estrogen Concentrations With Menopausal Status

Potischman, N. A., Swanson, C. A., Siiteri, P. K., & Hoover, R. N. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.11.756 · Cited by 218

Weight Gain, Body Mass Index, Hormone Replacement Therapy, and Postmenopausal Breast Cancer in a Large Prospective Study

Feigelson, H. S., Jonas, C. R., Teras, L. R., Thun, M. J., & Calle, E. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-03-0301 · Cited by 216

Body Size and Risk of Breast Cancer

Trentham‐Dietz, A., Newcomb, P. A., Storer, B. E., Longnecker, M. P., Baron, J. A., Greenberg, E. R., & Willett, W. C. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009057 · Cited by 213

Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin

PUGEAT, M. M., Crave, J. C., Elmidani, M., Nicolas, M. H., Garoscio-Cholet, M., Lejeune, H., Déchaud, H., & TOURNIAIRE, J. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90310-2 · Cited by 212

Hormones and prostate cancer: Current perspectives and future directions

Hsing, A. W., Reichardt, J. K. V., & Stanczyk, F. Z. (2002) · The Prostate · doi:10.1002/pros.10108 · Cited by 207

Association between Medications That Relax the Lower Esophageal Sphincter and Risk for Esophageal Adenocarcinoma

Lagergren, J., Bergström, R., Adami, H., & Nyrén, O. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-3-200008010-00007 · Cited by 202

Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden

Kaaks, R., Lundin, E., Manjer, J., Rinaldi, S., Biessy, C., Söderberg, S., Lenner, P., Janzon, L., Ríboli, E., Berglund, G. L., et al. (2002) · Cancer Causes & Control · doi:10.1023/a:1015270324325 · Cited by 198

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

Ish‐Shalom, D., Christoffersen, C. T., Vorwerk, P., Sacerdoti‐Sierra, N., Shymko, R. M., Naor, D., & MEYTS, P. D. (1997) · Diabetologia · doi:10.1007/s001250051393 · Cited by 193

Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study

Zeleniuch‐Jacquotte, A., Shore, R. E., Koenig, K. L., Akhmedkhanov, A., Afanasyeva, Y., Kato, I., Kim, M. Y., Rinaldi, S., Kaaks, R., & Toniolo, P. G. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601517 · Cited by 186

Obesity and endocrine disease

Kokkoris, P., & Pi-Sunyer, X. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00078-1 · Cited by 182

Case-Control Study of Non-Hodgkin's Lymphoma among Women and Heterosexual Men in the San Francisco Bay Area, California

Holly, E. A., Lele, C., Bracci, P. M., & McGrath, M. S. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010017 · Cited by 182

Role of Hormones in the Growth and Regression of Human Breast Cancer Cells (MCF-7) Transplanted Into Athymic Nude Mice 2

Shafie, S. M., & Grantham, F. H. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.1.51 · Cited by 181

Energy balance and cancer: the role of sex hormones

Key, T. J., Allen, N. E., Verkasalo, P. K., & Banks, E. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200068 · Cited by 180

Heritability of cervical tumours

Magnusson, P. K. E., Lichtenstein, P., & Gyllensten, U. B. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001201)88:5 · Cited by 179

Prediagnostic levels of C‐peptide, IGF‐I, IGFBP ‐1, ‐2 and ‐3 and risk of endometrial cancer

Lukanova, A., Zeleniuch‐Jacquotte, A., Lundin, E., Micheli, A., Arslan, A. A., Rinaldi, S., Muti, P. C., Lenner, P., Koenig, K. L., Biessy, C., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11544 · Cited by 178

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

Ma, J., Pollak, M., Giovannucci, E. L., Chan, J. M., Tao, Y., Hennekens, C. H., & Stampfer, M. J. (2000) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(00)90013-3 · Cited by 175

Mild hypogonadotropic hypogonadism in obese men

Strain, G. W., Zumoff, B., Kream, J., Strain, J. J., Deucher, R., Rosenfeld, R. S., Levin, J., & Fukushima, D. K. (1982) · Metabolism · doi:10.1016/0026-0495(82)90175-5 · Cited by 174

Handbook of obesity : etiology and pathophysiology

Bray, G. A., & Bouchard, C. (2004) · M. Dekker eBooks · Cited by 173

A simple estimate of mortality attributable to excess weight in the European Union

Banegas, J. R., López‐García, E., Gutiérrez-Fisac, J. L., Guallar‐Castillón, P., & Rodríguez‐Artalejo, F. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601538 · Cited by 168

Chapter 8: Estrogen Receptor-Mediated Processes in Normal and Cancer Cells

Dickson, R. B., & Stancel, G. M. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024237 · Cited by 168

Reducing the risk of cancer with healthy food choices and physical activity

Byers, T. (2002) · CA A Cancer Journal for Clinicians · Cited by 160

Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study

Zeleniuch‐Jacquotte, A., Akhmedkhanov, A., Kato, I., Koenig, K. L., Shore, R. E., Kim, M. Y., Levitz, M., Mittal, K., Raju, U., Banerjee, S. N., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1704 · Cited by 158

Height, Body Mass Index, and Ovarian Cancer: A Follow-Up of 1.1 Million Norwegian Women

Engeland, A., Tretli, S., & Bjørge, T. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg010 · Cited by 155

Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction.

Heuson, J.-C., & Legros, N. (1972) · PubMed · Cited by 151

Diet composition and the metabolic syndrome: what is the optimal fat intake?

Grundy, S. M., Abate, N. I., & Chandalia, M. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00988-3 · Cited by 146

Body weight: estimation of risk for breast and endometrial cancers

Ballard-Barbash, R. R., & Swanson, C. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.437 · Cited by 146

Circulating levels of insulin‐like growth factor‐I and risk of ovarian cancer

Lukanova, A., Lundin, E., Toniolo, P. G., Micheli, A., Akhmedkhanov, A., Rinaldi, S., Muti, P. C., Lenner, P., Biessy, C., Krogh, V., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10613 · Cited by 140

Risk factors for renal‐cell cancer in Shanghai, China

McLaughlin, J. K., Gao, Y., Gao, R., Zheng, W., Ji, B., Blot, W. J., & Fraumeni, J. F. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520411 · Cited by 139

Dietary factors and risk of pancreatic cancer: Results of a Canadian population‐based case‐control study

Howe, G. R., Jain, M., & Miller, A. B. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910450405 · Cited by 139

Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years

Törnberg, S., & Carstensen, J. M. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.65 · Cited by 136

Depressed Plasma Testosterone and Fractional Binding of Testosterone in Obese Males*

Amatruda, J. M., Harman, S. M., Pourmotabbed, G., & LOCKWOODF, D. H. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-2-268 · Cited by 132

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

di Prisco, M., Romano, G., Peruzzi, F., Valentinis, B., & Baserga, R. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978703 · Cited by 131

Western nutrition and the insulin resistance syndrome: A link to breast cancer

Stoll, B. A. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600700 · Cited by 131

Nutritional factors and pancreatic cancer in the francophone community in montréal, Canada

Ghadirian, P., Simard, A., Baillargeon, J., Maisonneuve, P., & Boyle, P. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910470102 · Cited by 130

Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix

Lacey, J. V., Swanson, C. A., Brinton, L. A., Altekruse, S. F., Barnes, W. A., Gravitt, P. E., Greenberg, M., Hadjimichael, O. C., McGowan, L., Mortel, R., et al. (2003) · Cancer · doi:10.1002/cncr.11567 · Cited by 130

Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women.

Rodríguez, C., Calle, E. E., Fakhrabadi‐Shokoohi, D., Jacobs, E. J., & Thun, M. J. (2002) · PubMed · Cited by 128

Obesity, Weight Gain, and Ovarian Cancer

Fairfield, K. M., Willett, W. C., ROSNER, B. A., Manson, J. E., Speizer, F. E., & Hankinson, S. E. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02053-7 · Cited by 125

Race, Nutritional Status, and Survival From Breast Cancer

Coates, R. J., Clark, W. S., Eley, J. W., Greenberg, R. S., Huguly, C. M., & Brown, R. L. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.21.1684 · Cited by 117

Anthropometric Characteristics, Physical Activity, and Risk of Non-Hodgkin's Lymphoma Subtypes and B-Cell Chronic Lymphocytic Leukemia: A Prospective Study

Cerhan, J. R. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf082 · Cited by 110

The effect of pre-morbid height and weight on the survival of breast cancer patients

Tretli, S., Haldorsen, T., & Ottestad, L. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.282 · Cited by 108

Circulating levels of insulin‐like growth factor I, its binding proteins ‐1,‐2, ‐3, C‐peptide and risk of postmenopausal breast cancer

Keinan‐Boker, L., Bueno-de-Mesquita, H. B., Kaaks, R., van Gils, C. H., van Noord, P. A. H., Rinaldi, S., Ríboli, E., Seidell, J. C., Grobbee, D. E., & Peeters, P. H. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.11193 · Cited by 107

Occurrence, trends and environmental etiology of pancreatic cancer

Weiderpass, E., Partanen, T. J., Kaaks, R., Vainio, H., Porta, M. S., Kauppinen, T. P., Ojajärvi, A., Boffetta, P., & Malats, N. (1998) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.295 · Cited by 107

Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review

Kaaks, R., Lukanova, A., & Sommersberg, B. (2000) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500421 · Cited by 105

Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women

Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J. (2003) · Cancer Causes & Control · doi:10.1023/a:1022518321634 · Cited by 104

Nutritional factors and pancreatic cancer: A case‐control study from South‐West Poland

Zatoński, W. A., Przewozniak, K., Howe, G. R., Maisonneuve, P., Walker, A. M., & Boyle, P. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480314 · Cited by 104

Early body size and subsequent weight again as predictors of breast cancer incidence (Iowa, United States)

Barnes-Josiah, D. L., Potter, J. D., Sellers, T. A., & Himes, J. H. (1995) · Cancer Causes & Control · doi:10.1007/bf00052771 · Cited by 103

Nutrition and renal cell cancer

Wolk, A., Lindblad, P., & Adami, H. (1996) · Cancer Causes & Control · doi:10.1007/bf00115634 · Cited by 103

Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian enhanced cancer surveillance system

Hanley, A. J., Johnson, K. C., Villeneuve, P. J., & Mao, Y. (2001) · International Journal of Cancer · doi:10.1002/ijc.1446 · Cited by 102

Height, Weight, Weight Change, and Ovarian Cancer Risk in the Netherlands Cohort Study on Diet and Cancer

Schouten, L. J. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf224 · Cited by 99

Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United States

Galanis, D. J., Kolonel, L. N., Lee, J., & Marchand, L. L. (1998) · Cancer Causes & Control · doi:10.1023/a:1008842613331 · Cited by 82

Body Mass Index at Age 18 Years and during Adult Life and Ovarian Cancer Risk

Lubin, F. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf184 · Cited by 82

Obesity and risk of renal cell cancer.

Chow, W., McLaughlin, J. K., Mandel, J. S., Wacholder, S., Niwa, S., & Fraumeni, J. F. (1996) · PubMed · Cited by 81

Serum concentrations of IGF‐I, IGFBP‐3 and c‐peptide and risk of hyperplasia and cancer of the breast in postmenopausal women

Schairer, C., Hill, D. A., Sturgeon, S. R., Fears, T. R., Pollak, M., Mies, C., Ziegler, R. G., Hoover, R. N., & Sherman, M. E. (2003) · International Journal of Cancer · doi:10.1002/ijc.11624 · Cited by 80

Nutrition and endometrial cancer

Hill, H. A., & Austin, H. D. (1996) · Cancer Causes & Control · doi:10.1007/bf00115635 · Cited by 78

Risk factors for renal‐cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors

Mellemgaard, A., Engholm, G., McLaughlin, J. K., & Olsen, J. H. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560113 · Cited by 77

Population-based, case-control study of blood C-peptide level and breast cancer risk.

Yang, G., Lu, G. G., Jin, F., Dai, Q., Best, R., Shu, X., Chen, J., Pan, X. Y., Shrubsole, M. J., & Zheng, W. (2001) · PubMed · Cited by 77

Body mass index and the risk of cancers of the gastric cardia and distal stomach in Shanghai, China.

Ji, B., Chow, W. H., Yang, G., McLaughlin, J. K., Gao, R. N., Zheng, W., Shu, X. O., Jin, F., Fraumeni, J. F., & Gao, Y. (1997) · PubMed · Cited by 76

Pre-morbid body-mass-index in breast cancer: Reversed effect on survival in hormone receptor negative patients

Maehle, B. O., & Tretli, S. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01807157 · Cited by 75

Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on menopausal status?

Kuper, H., Cramer, D. W., & Titus-Ernstoff, L. T. (2002) · Cancer Causes & Control · doi:10.1023/a:1015751105039 · Cited by 74

Leanness and Lung Cancer Risk: Fact or Artifact?

Henley, S. J., Flanders, W. D., Manatunga, A. K., & Thun, M. J. (2002) · Epidemiology · doi:10.1097/00001648-200205000-00006 · Cited by 74

Body mass and breast cancer: Relationship between method of detection and stage of disease

Reeves, M. J., Newcomb, P. A., Remington, P., Marcus, P. M., & Kenzie, W. R. M. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960115)77:2 · Cited by 73

Physical activity, body weight, and pancreatic cancer mortality

Lee, I.-M. M., Sesso, H. D., Oguma, Y., & Paffenbarger, R. S. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600782 · Cited by 73

Hormones and Hormone Antagonists: Mechanisms of Action in Carcinogenesis of Endometrial and Breast Cancer

Flötotto, T., Djahansouzi, S., Gläser, M., Hanstein, B., Niederacher, D., Brumm, C., & Beckmann, M. W. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-16936 · Cited by 70

Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I

Chapman, I. M., Hartman, M. L., Pieper, K. S., Skiles, E. H., Pezzoli, S. S., Hintz, R. L., & Thorner, M. O. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5040 · Cited by 70

Are energy and energy‐providing nutrients related to exocrine carcinoma of the pancreas?

Bueno-de-Mesquita, H. B., Moerman, C. J., Runia, S., & Maisonneuve, P. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910460319 · Cited by 70

Fat and the liver--a molecular overview.

Harrison, S. A., & Diehl, A. M. (2002) · PubMed · Cited by 70

Progress in obesity research

Westerterp, K. R. (2003) · Cited by 70

Genetics of insulin resistance

Pedersen, O. B. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212085 · Cited by 68

Storing up problems: the medical case for a slimmer nation

Prentice, A. (2004) · Clinical Medicine · doi:10.7861/clinmedicine.4-2-99 · Cited by 66

Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.

Hirose, K., Toyama, T., Iwata, H., Takezaki, T., Hamajima, N., & Tajima, K. (2003) · PubMed · Cited by 60

Anthropometric Measures and Body Composition

Willett, W. C. (1998) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195122978.003.10 · Cited by 54

High-insulinogenic nutrition—an etiologic factor for obesity and the metabolic syndrome?

Kopp, W. (2003) · Metabolism · doi:10.1016/s0026-0495(02)05294-0 · Cited by 51

Variations on the Picturesque: Authority, Play, and Practice

Harrison, G., & Heydt-Stevenson, J. (2002) · European Romantic Review · doi:10.1080/10509580212768 · Cited by 50

Second Malignant Neoplasms in Long-Term Survivors of Childhood Rhabdomyosarcoma

Scaradavou, A., Heller, G., Sklar, C. A., Ren, L., & Ghavimi, F. (1995) · Cancer · doi:10.1002/1097-0142(19951115)76:10 · Cited by 47

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807

Body Fatness and Cancer — Viewpoint of the IARC Working Group

Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1606602 · Cited by 3,596

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,272

Obesity and cancer

Pischon, T., Nöthlings, U., & Boeing, H. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006976 · Cited by 330

Epidemiological and molecular mechanisms aspects linking obesity and cancer

Osório–Costa, F., Rocha, G. Z., Dias, M. M., & Carvalheira, J. B. C. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200013 · Cited by 76

Obesity and cancer: Pathophysiological and biological mechanisms

Renehan, A. G., Roberts, D. L., & Dive, C. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450801954303 · Cited by 418

Linking Obesity, Metabolism, and Cancer

Vučenik, I., Jones, L. P., & McLenithan, J. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_50 · Cited by 3

Obesity as a Major Risk Factor for Cancer

Pergola, G. D., & Silvestris, F. (2013) · Journal of Obesity · doi:10.1155/2013/291546 · Cited by 1,007