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Cancer nanotechnology: opportunities and challenges
Abstract
Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry. These devices include nanovectors for the targeted delivery of anticancer drugs and imaging contrast agents. Nanowires and nanocantilever arrays are among the leading approaches under development for the early detection of precancerous and malignant lesions from biological fluids. These and other nanodevices can provide essential breakthroughs in the fight against cancer.
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“Targeted therapy is thus the combination of targeted delivery with sustained drug release, which allows the maximum utilization of the drug delivered at the tumor site.236”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [236]
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Higgins, J. P., Arrivo, S. M., Thurau, G., Green, R. L., Bowen, W. E., Lange, A. J., Templeton, A. C., Thomas, D. L., & Reed, R. A. (2003) · Analytical Chemistry · doi:10.1021/ac0207980 · Cited by 76
Heath, J. R. (2003) · Molecular Imaging and Biology · doi:10.1016/j.mibio.2003.10.001 · Cited by 68
Bergey, E. J., Lévy, L., Wang, X., Krebs, L. J., Lal, M., Kim, K.-S., Pakatchi, S., Liebow, C., & Prasad, P. N. (2002) · Biomedical Microdevices · doi:10.1023/a:1020906307053 · Cited by 67
Li, X., John, J. S., Coffer, J. L., Chen, Y., Pinizzotto, R. F., Newey, J., Reeves, C. L., & Canham, L. (2000) · Biomedical Microdevices · doi:10.1023/a:1009951121205 · Cited by 65
Nanotechnology and Tumor Imaging: Seizing an Opportunity
Sullivan, D. C., & Mauro Ferrari, B. (2004) · Molecular Imaging · doi:10.1162/1535350042973526 · Cited by 64
Self-citationSanthakumaran, L. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh526 · Cited by 64
Silicon membrane nanofilters from sacrificial oxide removal
Chu, W.-H., Chin, R., Huen, T., & Mauro Ferrari, B. (1999) · Journal of Microelectromechanical Systems · doi:10.1109/84.749400 · Cited by 63
Nanotechnology in Early Detection of Cancer
Srinivas, P. R., Barker, P., & Srivastava, S. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780460 · Cited by 62
Release of Biologically Functional Interferon-Alpha from a Nanochannel Delivery System
Lesinski, G. B., Sharma, S., Varker, K. A., Sinha, P. M., Mauro Ferrari, B., & Carson, W. E. (2005) · Biomedical Microdevices · doi:10.1007/s10544-005-6174-8 · Cited by 55
Adhesion of Microfabricated Particles on Vascular Endothelium: A Parametric Analysis
Decuzzi, P., Lee, S. B., Decuzzi, M., & Mauro Ferrari, B. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000030255.36748.d3 · Cited by 54
Biochemical and Immunological Properties of Cytokines Conjugated to Dendritic Polymers
Lee, S. C., Parthasarathy, R., Botwin, K., Kunneman, D., Rowold, E., Lange, G. W., Klover, J. A., Abegg, A. L., Zobel, J., Beck, T., et al. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000042048.18186.ff · Cited by 53
Bioassays Based on Molecular Nanomechanics
Majumdar, A. (2002) · Disease Markers · doi:10.1155/2002/856032 · Cited by 53
Microfabrication of Silicon-Based Nanoporous Particulates for Medical Applications
Cohen, M. H., Melnik, K., Boiarski, A. A., Mauro Ferrari, B., & Martin, F. J. (2003) · Biomedical Microdevices · doi:10.1023/a:1025768411300 · Cited by 49
Tetrakis(trimethylsilyl)cyclobutadiene and Tetrakis(trimethylsilyl)tetrahedrane
Maier, G., Neudert, J., & Wolf, O. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010504)40:9 · Cited by 47
Yan, F., Xu, H., Anker, J. N., Kopelman, R., Ross, B. D., Rehemtulla, A., & Reddy, R. (2004) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2004.074 · Cited by 44
Opportunities for Nanotechnology-Based Innovation in Tissue Proteomics
Geho, D. H., Lahar, N., Mauro Ferrari, B., Petricoin, E. F., & Liotta, L. A. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000042053.51016.b4 · Cited by 32
Vector Targeting for Therapeutic Gene Delivery
Curiel, D. T., & Douglas, J. T. (2002) · doi:10.1002/0471234303 · Cited by 31
Lee, S. C., Parthasarathy, R. V., Duffin, T. D., Botwin, K., Zobel, J., Beck, T., Lange, G. W., Kunneman, D., Janssen, R. S., Rowold, E., et al. (2001) · Biomedical Microdevices · doi:10.1023/a:1011429404950 · Cited by 27
Microelectronic DNA Assay for the Detection of BRCA1 Gene Mutations
Chen, H., Han, J., Li, J., & Meyyappan, M. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000013366.85609.dd · Cited by 13
Cell factories for fighting cancer
Bergers, G., & Hanahan, D. (2001) · Nature Biotechnology · doi:10.1038/83457 · Cited by 12
Immunoliposomes: A Targeted Delivery Tool for Cancer Treatment
Pirollo, K. F., Xu, L., & Chang, E. H. (2002) · doi:10.1002/0471234303.ch3 · Cited by 11
Determination of Eigenstresses from Curvature Data
Ferrari, M., & Weber, M. (1992) · MRS Proceedings · doi:10.1557/proc-276-221 · Cited by 2
Self-citationSlow vasomotor fluctuation in fMRI of anesthetized child brain
Kiviniemi, V., Jauhiainen, J., Tervonen, O., P��kk�, E., Oikarinen, J., Vainionp��, V., Rantala, H., & Biswal, B. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200009)44:3
Flagged first, then by citations
2 of the 135 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Decuzzi, P., Lee, S., Bhushan, B. & Ferrari, M. Non-specific interaction of nanoparticles as drug delivery and nanoharvesting agents within the vasculature. Ann. Biomed. Eng. (in the press). Mathematical models drive the design of nanovectors for optimal use in therapeutics and diagnostics.
- Ferrari, M. Therapeutic microdevices and methods of making and using same. US Patent 6,107,102 (2000). Early investigation of multifunctional drug-delivery nanosystems.
- Hayflick, L. Mortality and immortality at the cellular level. Biochemistry 62, 1180–1190 (1997).
- Matsumura, Y. & Maeda H. A new concept for macromolecular therapies in cancer chemotherapy: mechanisms of tumortropic accumulation of proteins and the antitumor agents SMANCS. Cancer Res. 6, 6397–6392 (1986).
- Sel, Y. N. et al. Comparison of vascular permeability and enzymatic activation of the polymeric prodrug HPMA copolymer–doxorubicin (PK1) in human tumor xenografts. Proc. Am. Assoc. Cancer Res. 90, 41 (1999).
- Wu, J., Akaka, T. & Maeda, H. Modulation of enhanced permeability in tumor by a bradykinine antagonist, a cyclooxygenase inhibitor. Cancer Res. 58, 159–165 (1998).
- Ferrari, M. et al. Particles for oral delivery of peptides and proteins. US Patent 6,355,270 (2002).
Cited by
Sorted by citations
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873
Drug delivery and nanoparticles: Applications and hazards
de Jong (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s596 · Cited by 3,854
The golden age: gold nanoparticles for biomedicine
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El‐Sayed, M. A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15237h · Cited by 3,659
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,443
Metadata
- Authors
- Ferrari, M.
- Venue
- Nature Reviews Cancer
- Published
- 2005-03-01
- Volume
- 5
- Issue
- 3
- Pages
- 161-171
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1989195046
- Cited by
- 4,558
- References
- 135
- Citations by year
- 2026: 60 · 2025: 99 · 2024: 137 · 2023: 181 · 2022: 157 · 2021: 191 · 2020: 221 · 2019: 240 · 2018: 257 · 2017: 291 · 2016: 287 · 2015: 297 · 2014: 328 · 2013: 367 · 2012: 294
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- cancer nanotechnology, nanovectors, targeted drug delivery, anticancer agents, imaging contrast agents, nanowires, early cancer detection, precancerous lesions, biological fluids
- MeSH terms
- Antineoplastic Agents, Contrast Media, Diagnosis, Differential, Equipment Design, Humans, Neoplasms, Nanotechnology
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