Cited by 309Cancer-related Molecular PathwaysDevelopmental Biology and Gene RegulationCell death mechanisms and regulation

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The p53 family in differentiation and tumorigenesis

Stiewe, Thorsten·2007·Nature Reviews Cancer

DOI 10.1038/nrc2072

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Abstract

The role of p53 as a tumour suppressor is generally attributed to its ability to stop the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. The relatives and evolutionary predecessors of p53 - p63 and p73 - share the tumour-suppressor activity of p53 to some extent, but also have essential functions in embryonic development and differentiation control. Recent evidence indicates that these ancestral functions in differentiation control contribute to the tumour-suppressor activity that the p53 family is famous for.

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Surfing the p53 network
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×
“jpg" NDATA ITEM> ]> The tumour suppressor p53 is known as the 'guardian of the genome' owing to its ability to integrate many signals that control life or deat”
Background
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Authors: Stiewe, T.
Affiliations: University of Würzburg (DE)
Corresponding author: Stiewe, Thorsten
ORCID: Stiewe, Thorsten
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2007-02-01
Volume: 7
Issue: 3
Pages: 165-167
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2072
OpenAlex: W2012024423
Cited by: 306
References: 38
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 11 · 2019: 7 · 2018: 16 · 2017: 10 · 2016: 8 · 2015: 18 · 2014: 27 · 2013: 31 · 2012: 21
FWCI: 2.98
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53 family, p63, p73, tumour suppressor, cell differentiation, carcinogenesis, embryonic development, cell cycle arrest, apoptosis, transcription factors
MeSH terms: Animals, Cell Differentiation, Cell Transformation, Neoplastic, Humans, Genes, p53

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The p53 family in differentiation and tumorigenesis

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