The p53 family in differentiation and tumorigenesis

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,264

Tumor spectrum analysis in p53-mutant mice

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p63 is a p53 homologue required for limb and epidermal morphogenesis

Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 2,015

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

Yang, A., Walker, N., Bronson, R. T., Kaghad, M., Oosterwegel, M. A., Bonnin, J., Vagner, C., Bonnet, H., Dikkes, P., Sharpe, A. H., et al. (2000) · Nature · doi:10.1038/35003607 · Cited by 1,022

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

Lin, T., Chao, C., Saito, S., Mazur, S. J., Murphy, M. E., Appella, E., & Xu, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1211 · Cited by 859

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 815

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development · doi:10.1101/gad.1339905 · Cited by 810

p63 is the molecular switch for initiation of an epithelial stratification programPreprint

Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004) · Genes & Development · doi:10.1101/gad.1165104 · Cited by 622

The biology of CML blast crisis

Calabretta, B., & Perrotti, D. (2004) · Blood · doi:10.1182/blood-2003-12-4111 · Cited by 608

A subset of p53-deficient embryos exhibit exencephaly

Sah, V. P., Attardi, L. D., Mulligan, G., Williams, B. O., Bronson, R. T., & Jacks, T. (1995) · Nature Genetics · doi:10.1038/ng0695-175 · Cited by 594

Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family

Flores, E. R., Sengupta, S., Miller, J. B., Newman, J. J., Bronson, R. T., Crowley, D. G., Yang, A., McKeon, F., & Jacks, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.019 · Cited by 499

p63 and p73: Roles in Development and Tumor Formation

Moll, U. M., & Slade, N. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.371.2.7 · Cited by 488

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1874-1887.2001 · Cited by 464

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

Rocco, J. W., Leong, C., Kuperwasser, N., DeYoung, M. P., & Ellisen, L. W. (2006) · Cancer Cell · doi:10.1016/j.ccr.2005.12.013 · Cited by 435

Links between Tumor Suppressors

Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., & Piccolo, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00308-8 · Cited by 386

Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland

Ito, T., Seyama, T., Mizuno, T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Nakamura, N., & Akiyama, M. (1992) · American Journal of Otolaryngology · doi:10.1016/0196-0709(92)90038-u · Cited by 350

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of functionPreprint

Keller, C., Arenkiel, B. R., Coffin, C. M., Bardeesy, N. M., DePinho, R. A., & Capecchi, M. R. (2004) · Genes & Development · doi:10.1101/gad.1244004 · Cited by 304

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

Candi, E., Rufini, A., Terrinoni, A., Dinsdale, D. D., Ranalli, M., Paradisi, A., Laurenzi, V. D., Spagnoli, L. G., Catani, M. V., Ramadan, S. M., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401926 · Cited by 266

Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line

Laurenzi, V. D., Raschellà, G., Barcaroli, D., Annicchiarico‐Petruzzelli, M., Ranalli, M., Catani, M. V., Tanno, B., Costanzo, A., Levrero, M., & Melino, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15226 · Cited by 183

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.

Rotter, V., Schwartz, D., Almon, E. B., Goldfinger, N., Kapon, A., Meshorer, A., Donehower, L. A., & Levine, A. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9075 · Cited by 182

Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients

Casciano, I., Mazzocco, K., Boni, L., Pagnan, G., Banelli, B., Allemanni, G., Ponzoni, M., Tonini, G., & Romani, M. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400993 · Cited by 181

Involvement of p53 in cell differentiation and development

Almog, N., & Rotter, V. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00012-7 · Cited by 163

Role of p73 in malignancy: tumor suppressor or oncogene?

Stiewe, T., & Pützer, B. M. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400995 · Cited by 156

Small-Molecule MDM2 Antagonists as a New Therapy Concept for Neuroblastoma

Maerken, T. V., Speleman, F., Vermeulen, J., Lambertz, I., Clercq, S. D., Smet, E. D., Yigit, N., Coppens, V., Philippé, J., Paepe, A. D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0792 · Cited by 154

Childhood solid tumours: a developmental disorder

Scotting, P. J., Walker, D. A., & Perilongo, G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1633 · Cited by 152

P53 Regulates Myogenesis by Triggering the Differentiation Activity of Prb

Porrello, A., Cerone, M. A., Coen, S., Gurtner, A., Fontemaggi, G., Cimino, L., Piaggio, G., Sacchi, A., & Soddu, S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1295 · Cited by 124

p53 family members in myogenic differentiation and rhabdomyosarcoma development

Çam, H., Griesmann, H., Beitzinger, M., Hofmann, L., Beinoravičiūtė-Kellner, R., Sauer, M., Hüttinger-Kirchhof, N., Oswald, C., Friedl, P., Gattenlöhner, S., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.024 · Cited by 109

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors

Keyes, W. M., Vogel, H. S., Koster, M. I., Guo, X., Qi, Y., Petherbridge, K. M., Roop, D. R., Bradley, A., & Mills, A. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602477103 · Cited by 88

Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model.

Nakagawara, A., & Ohira, M. (2004) · Cancer Letters · doi:10.1016/s0304-3835(03)00457-9 · Cited by 81

Rhabdomyosarcoma development in mice lacking Trp53 and Fos

Fleischmann, A., Jochum, W., Eferl, R., Witowsky, J. A., & Wagner, E. F. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00280-0 · Cited by 72

Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice.

Nanni, P., Nicoletti, G., Giovanni, C. D., Croci, S., Astolfi, A., Landuzzi, L., Carlo, E. D., Iezzi, M., Musiani, P., & Lollini, P. (2003) · PubMed · Cited by 69

δEF1 repressor controls selectively p53 family members during differentiation

Fontemaggi, G., Gurtner, A., Damalas, A., Costanzo, A., Higashi, Y., Sacchi, A., Strano, S., Piaggio, G., & Blandino, G. (2005) · Oncogene · doi:10.1038/sj.onc.1208891 · Cited by 45

Spatiotemporal Switch from ΔNp73 to TAp73 Isoforms during Nephrogenesis

Saifudeen, Z. R., Diavolitsis, V. M., Stefkova, J., Dipp, S., Fan, H., & El-Dahr, S. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414575200 · Cited by 29

The p53 family inhibitor ΔNp73 interferes with multiple developmental programs

Hüttinger-Kirchhof, N., Çam, H., Griesmann, H., Hofmann, L., Beitzinger, M., & Stiewe, T. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401809 · Cited by 25

Deregulated expression of ΔNp73α causes early embryonic lethality

Erster, S. H., Palacios, G. F., Rosenquist, T. A., Chang, C. H. S., & Moll, U. M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401743 · Cited by 10

The first 30 years of p53: growing ever more complex.

Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705

p53 polymorphisms: cancer implications

Whibley, C., Pharoah, P. D. P., & Hollstein, M. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2584 · Cited by 677

Biological response of cancer cells to radiation treatment

Baskar, R., Dai, J., Nei, W. L., Yeo, R., & Yeoh, K. (2014) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2014.00024 · Cited by 696

Strategies for optimizing the response of cancer and normal tissues to radiation

Moding, E. J., Kastan, M. B., & Kirsch, D. G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4003 · Cited by 474

Regulation and function of the p53-related proteins: same family, different rules

Lohrum, M. A. E., & Vousden, K. H. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01736-0 · Cited by 122

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

Molchadsky, A., Rivlin, N., Brosh, R., Rotter, V., & Sarig, R. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq101 · Cited by 161

p63 and p73, the ancestors of p53

Dotsch, V., Bernassola, F., Coutandin, D., Candi, E., & Melino, G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004887 · Cited by 326

The p53 Gene Family: Control of Cell Proliferation and Developmental Programs

Morgunkova, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0210-4 · Cited by 20

p53 Gene Family: Structural, Functional and Evolutionary Features

D’Erchia, A. M., Tullo, A., Pesole, G., Saccone, C., & Sbisà, E. (2003) · Current Genomics · doi:10.2174/1389202033350173 · Cited by 11