Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

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1. Highlights of Pentacyclic Triterpenoids in the Cancer Settings
   Jorge A. R. Salvador, Ana S. Leal, Daniela P.S. Alho, Bruno M. F. Gonçalves, Ana S. C. Valdeira, Vanessa I.S. Mendes, Yongkui Jing · 2014 · Studies in natural products chemistry
2. Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage
   Daniela Rodrigues, Ana Cláudia Viotto, Robert Garcia Checchia, Andreza Barbosa Gomide, Divinomar Severino, Rosângela Itri, Maurı́cio S. Baptista, Waleska K. Martins · 2016 · Photochemical & Photobiological Sciences
3. Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-target Drugs
   André St. Schrattenholz, Karlfried Groebe, Vukić Šoškić · 2010 · Methods in molecular biology
4. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways
   Jia Liu, Lanhong Zheng, Jiateng Zhong, Ning Wu, Ge Liu, Xiukun Lin · 2014 · Oncology Reports
5. Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells
   DeDe Kwun-Wai Man, Luca Casettari, Marco Cespi, Giulia Bonacucina, Giovanni Filippo Palmieri, Stephen Cho Wing Sze, Gph Leung, Jenny K.W. Lam, Philip Chi Lip Kwok · 2015 · Molecular Pharmaceutics
6. Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers
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7. In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention
   Christina N. Ramirez, Wenji Li, Chengyue Zhang, Renyi Wu, Shan Su, Chao Wang, Linbo Gao, Ran Yin, Ah‐Ng Tony Kong · 2017 · The AAPS Journal
8. Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury
   Qiaoyan Hui, Marcus Karlstetter, Zhenhua Xu, Jing Yang, Lingli Zhou, Hanna M. Eilken, Carsten Terjung, Hongkwan Cho, Junsong Gong, Michael J. Lai et al. · 2019 · Free Radical Biology and Medicine
9. Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs
   Latanya M. Scott, Liwei Chen, Kenyon G. Daniel, Wesley H. Brooks, Wayne C. Guida, Harshani R. Lawrence, Saı̈d M. Sebti, Nicholas J. Lawrence, Jie Wu · 2010 · Bioorganic & Medicinal Chemistry Letters
10. Unifying Mechanisms of Action of the Anticancer Activities of Triterpenoids and Synthetic Analogs
    Stephen H Safe, Paul L. Prather, Lisa K. Brents, Gayathri Chadalapaka, Indira Jutooru · 2012 · Anti-Cancer Agents in Medicinal Chemistry
11. Immunotherapy: Beyond Anti–PD-1 and Anti–PD-L1 Therapies
    Scott Joseph Antonia, Johan F. Vansteenkiste, Edmund K. Moon · 2016 · American Society of Clinical Oncology Educational Book
12. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease
    Mohammad Amin Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Stan Shelkovnikov, Seyed H. Farzaneh, Mahyar Khazaeli, Colin J. Meyer · 2013 · Redox Biology
13. The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer
    Kim M. Tran, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Michael B. Sporn, Patricia Ann Pioli, Lalji K. Gediya, Vincent C.O. Njar, Karen T. Liby · 2012 · Carcinogenesis
14. Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis
    Sung Hee Choi, Byung‐Gyu Kim, Janet Robinson, Stephen P. Fink, Min Yan, Michael B. Sporn, Sanford D. Markowitz, John J. Letterio · 2014 · Journal of Clinical Investigation
15. Corosolic Acid Triggers Mitochondria and Caspase‐dependent Apoptotic Cell Death in Osteosarcoma MG‐63 Cells
    Xiaobing Cai, Hao Zhang, Dake Tong, Zhangyong Tan, Dong Cho Han, Fang Ji, Wei Hu · 2011 · Phytotherapy Research
16. β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling
    Marcus J. C. Long, Hongyu Lin, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, Yimon Aye · 2017 · Cell chemical biology
17. Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers
    Efrén Pérez‐Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez‐Barrios, Hinrich Gronemeyer, Ángel R. de Lera, William Bourguet · 2009 · Journal of Medicinal Chemistry
18. The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor–Negative Mammary Carcinogenesis in Polyoma Middle T Mice
    Kim Tran, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Michael B. Sporn, Karen T. Liby · 2012 · Cancer Prevention Research
19. Silver complexation and tandem mass spectrometry for differentiation of triterpenoid saponins from the roots of Pulsatilla chinensis (Bunge) Regel
    Lin Li Cheng, Min Zhang, Peng Zhang, Zhihang Song, Zhongjun Ma, Haibin Qu · 2008 · Rapid Communications in Mass Spectrometry
20. Synthesis and cytotoxicity evaluation of oleanolic acid derivatives
    Hao Jia, Jun Hong Liu, Xiaoan Wen, Hongbin Sun · 2013 · Bioorganic & Medicinal Chemistry Letters
21. Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro
    Kyoung Jin Nho, Jin Mi Chun, Ho Kyoung Kim · 2013 · Food and Chemical Toxicology
22. Avicin D Selectively Induces Apoptosis and Downregulates p-STAT-3, bcl-2, and Survivin in Cutaneous T-Cell Lymphoma Cells
    Chunlei Zhang, Baoqiang Li, Amos S. Gaikwad, Valsala Haridas, Zhi–Xiang Xu, Jordan U. Gutterman, Madeleine A. Duvic · 2008 · Journal of Investigative Dermatology
23. Synthetic Triterpenoids Target the Arp2/3 Complex and Inhibit Branched Actin Polymerization
    Ciric To, Brian H. Shilton, Gianni M. Di Guglielmo · 2010 · Journal of Biological Chemistry
24. Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads
    Hung The Dang, Gyeoung-Jin Kang, Eun Sook Yoo, Jongki Hong, Jae Sue Choi, Hyung Sik Kim, Hae Young Chung, Jee Hyung Jung · 2010 · Bioorganic & Medicinal Chemistry
25. Recent advances in natural small molecules as drug delivery systems
    Shiyao Fu, Xin Hao Yang · 2023 · Journal of Materials Chemistry B
26. Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
    Chen Qu, Bin Li, Yimu Lai, Hechu Li, Anthony J. Windust, Lorne J. Hofseth, Mitzi Nagarkatti, Prakash S. Nagarkatti, Xing Li Wang, Dongqi Tang et al. · 2015 · Journal of Ethnopharmacology
27. Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia
    Twee Tsao, Steven Mitchell Kornblau, Stephen H Safe, Julie C. Watt, Vivian R. Ruvolo, Wenjing Chen, Yihua Qiu, Kevin R. Coombes, Zhenlin Ju, Maen Abdelrahim et al. · 2010 · Cancer Research
28. Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates
    Haiwei Li, Man Li, Renyang Xu, Shouxin Wang, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao · 2018 · European Journal of Medicinal Chemistry
29. Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors
    Rina Das, Dinesh Kumar Mehta, Meenakshi Dhanawat · 2022 · Mini-Reviews in Medicinal Chemistry
30. Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: Synthesis, biological evaluation and docking studies
    Pamita Bhandari, Neeraj Kumar Patel, Rahul Prakashchand Gangwal, Abhay T. Sangamwar, Kamlesh K. Bhutani · 2014 · Bioorganic & Medicinal Chemistry Letters
31. Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress
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32. Natural Products Drug Discovery
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33. Blockage of Stat3 With CDDO-Me Inhibits Tumor Cell Growth in Chordoma
    Yang Cao, Francis John Hornicek, Kirkham B. Wood, Joseph Hasbrouck Schwab, Edwin Choy, Henry J. Mankin, Zhenfeng Duan · 2010 · Spine
34. Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling
    Hong Jin Lee, Jae-Young So, Andrew DeCastro, Amanda K. Smolarek, Shiby Paul, Hubert Maehr, Milan R. Uskoković, Nanjoo Suh · 2010 · The Journal of Steroid Biochemistry and Molecular Biology
35. CDDO-Imidazolide Induces DNA Damage, G2/M Arrest and Apoptosis in BRCA1-Mutated Breast Cancer Cells
    Eun‐Hee Kim, Chu‐Xia Deng, Michael B. Sporn, Karen T. Liby · 2011 · Cancer Prevention Research
36. Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention
    Aimee L. Eggler, Sergey N. Savinov · 2013 · Springer eBooks
37. An apolar Pistacia lentiscus L. leaf extract: GC-MS metabolic profiling and evaluation of cytotoxicity and apoptosis inducing effects on SH-SY5Y and SK-N-BE(2)C cell lines
    Simona Piccolella, Paola Nocera, Petronia Carillo, Pasqualina Woodrow, Vincenza Greco, Lorenzo Manti, Antonio Fiorentino, Severina Pacifico · 2016 · Food and Chemical Toxicology
38. The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling
    Kristen J. Bubb, Cindy Kok, Owen Tang, Nathalie B. Rasko, Åsa Birna Birgisdottir, Thomas Hansen, Rebecca Helen Ritchie, Ravinay Bhindi, Scott A. Reisman, Colin J. Meyer et al. · 2017 · Free Radical Biology and Medicine
39. Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells
    Kotamballi N. Chidambara Murthy, Guddadarangavvanahally K. Jayaprakasha, Stephen H Safe, Bhimanagouda S. Patil · 2020 · Food & Function
40. A Pharmacological and Phytochemical Evaluation of Medicinal Plants Used by the Harbang Clan of the Tripura Tribal Community of Mirsharai Area, Chittagong District, Bangladesh
    Mohammed Rahmatullah, Md Asifur Rahman, Md Shahadat Hossan, M. Taufiq-ur-Rahman, Rownak Jahan, Md. Ariful Haque Mollik · 2010 · The Journal of Alternative and Complementary Medicine
41. Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications
    Dorota Magdalena Radomska-Leśniewska, Agata Hevelke, Piotr Skopiński, Barbara Joanna Bałan, Jarosław Jóźwiak, Dariusz Rokicki, Ewa Skopińska-Różewska, Agata Białoszewska · 2015 · Pharmacological Reports
42. Oleanane derivatives for pharmaceutical use: A patent review (2000–2016)
    Masullo, Milena, Pizza, Cosimo, Piacente, Sonia · 2017 · Expert Opinion on Therapeutic Patents
43. Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs
    Wanda Baer‐Dubowska, Maria Narożna, Violetta Krajka‐Kuźniak · 2021 · Molecules
44. Modulation of inflammatory responses by diterpene acids from Helianthus annuus L.
    Rodrigo Dı́az, Sonsoles Hortelano, Natalia Girón, J.F. Martí-Massó, Benjamín Rodriguez, Ángel Villar, Beatriz de las Heras · 2008 · Biochemical and Biophysical Research Communications
45. Down-Regulation of Human Epidermal Growth Factor Receptor 2/neu Oncogene by Corosolic Acid Induces Cell Cycle Arrest and Apoptosis in NCI-N87 Human Gastric Cancer Cells
    Myung Sun Lee, Eun Young Cha, Phương Thiện Thương, Ji Yeon Kim, Moonsang Ahn, Ji Young Sul · 2010 · Biological and Pharmaceutical Bulletin
46. Cancer chemopreventive pharmacology of phytochemicals derived from plants of dietary and non-dietary origin: implication for alternative and complementary approaches
    Mohammad Fahad Ullah, Showket H. Bhat, Eram Husain, Faisel M. Abuduhier, S.M. Hadi, Fazlul H. Sarkar, Aamir Ahmad · 2014 · Phytochemistry Reviews
47. Exploiting mitochondrial apoptosis for the treatment of cancer
    Simone Fulda · 2010 · Mitochondrion
48. Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ Stress
    Hagir B. Suliman, Claude A. Piantadosi · 2014 · Current Pharmaceutical Design
49. CRA(Crosolic Acid) isolated from Actinidia valvata Dunn.Radix induces apoptosis of human gastric cancer cell line BGC823 in vitro via down-regulation of the NF-κB pathway
    Qi-Lai Cheng, LI Hong-liang, Ying-Chen Li, Zhao-Wen Liu, Xiaohua Guo, Yi-Jian Cheng · 2017 · Food and Chemical Toxicology
50. Time Course of Pentacyclic Triterpenoids from Fruits and Leaves of Olive Tree (Olea europaea L.) cv. Picual and cv. Cornezuelo during Ripening
    Juan Peragón · 2013 · Journal of Agricultural and Food Chemistry
51. Unraveling the Peculiar Features of Mitochondrial Metabolism and Dynamics in Prostate Cancer
    Fabrizio Fontana, Martina Anselmi, Patrízia Limonta · 2023 · Cancers
52. Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARγ/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO
    Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Álvarez, Rosana Álvarez, Annica Jacobson, Angela Nebbioso, Ángel R. de Lera, Lucia Altucci, Hinrich Gronemeyer · 2009 · Cancer Cell
53. Biotransformation using Mucor rouxii for the production of oleanolic acid derivatives and their antimicrobial activity against oral pathogens
    Clarissa S. Capel, Ana Clara de Souza, Tatiane Cruz de Carvalho, João Paulo Barreto Sousa, Sérgio Ricardo Ambrósio, Carlos Henrique Gomes Martins, Wilson Roberto Cunha, Rosario Hernández‐Galán, Niege Araçari Jacometti Cardoso Furtado · 2011 · Journal of Industrial Microbiology & Biotechnology
54. Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis
    Guanghui Wang, Fuquan Jiang, Yinghui Duan, Zhiping Zeng, Fan Chen, Yi Dai, Jiebo Chen, Jin‐Xing Liu, Jie Liu, Hu Zhou et al. · 2012 · Cancer Research
55. RXRs: Collegial Partners
    Federica Gilardi, Béatrice Desvergne · 2014 · Sub-cellular biochemistry/Subcellular biochemistry
56. Platforms and networks in triterpenoid pharmacology
    Michael B. Sporn, Karen T. Liby, Mark M. Yore, Nanjoo Suh, Adriana Albini, Tadashi Honda, Chitra Sundararajan, Gordon W. Gribble · 2007 · Drug Development Research
57. Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells
    Shufeng Zhou, Yanyang Wang, Yinxue Yang, Zhixue He, Ren Zhao, Hong Zhe, Xueji Zhang, Shuting Pan, Wei Duan, Tianxin Yang et al. · 2015 · Drug Design Development and Therapy
58. A New Rexinoid, NRX194204, Prevents Carcinogenesis in Both the Lung and Mammary Gland
    Karen T. Liby, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Matthew D. Wood, Roshantha A.S. Chandraratna, Michael B. Sporn · 2007 · Clinical Cancer Research
59. Retinoids Regulate the Formation and Degradation of Gap Junctions in Androgen-Responsive Human Prostate Cancer Cells
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60. A Natural‐Product Switch for a Dynamic Protein Interface
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61. Glycogen Synthase Kinase 3β Regulates Cell Death Induced by Synthetic Triterpenoids
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62. Steroidal Scaffolds as FXR and GPBAR1 Ligands: From Chemistry to Therapeutical Application
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63. Nuclear factor erythroid-2 related factor 2 Nrf2 -mediated protein quality control in cardiomyocytes
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64. Triterpenoids from Dysoxylum genus and their biological activities
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65. Activation of nuclear factor E2‐related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development†
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66. Combination chemoprevention of HER2/neu-induced breast cancer using a COX-2 inhibitor and an RXR-selective retinoid
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67. Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates
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68. Synthesis and biological evaluation of novel pentacyclic triterpene α -cyclodextrin conjugates as HCV entry inhibitors
    Sulong Xiao, Qi Wang, Longlong Si, Xiaoshu Zhou, Yongmin Zhang, Lihe Zhang, Demin Zhou · 2016 · European Journal of Medicinal Chemistry
69. Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism
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70. CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells
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71. Exploration of the Antiplatelet Activity Profile of Betulinic Acid on Human Platelets
    Andreas G. Tzakos, Vassiliki G. Kontogianni, Maria E. Tsoumani, Eleni Kyriakou, John Hwa, Francisco A. Rodrigues, Alexandros D. Tselepis · 2012 · Journal of Agricultural and Food Chemistry
72. Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoids
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73. Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy
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74. A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin
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75. Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies
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76. A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid
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77. Small-Molecule Drugs for the Treatment of Inflammatory Bowel Disease
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78. Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids
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79. Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid
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80. Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition
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81. Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives
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82. A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)
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83. A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy
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84. Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet
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85. Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6
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86. Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
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87. Calcineurin Signaling as a Negative Determinant of Keratinocyte Cancer Stem Cell Potential and Carcinogenesis
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88. Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity
    Dorrah Deeb, Xiaohua Gao, Yongbo Liu, Sahn-Ho Kim, Kirit R. Pindolia, Ali S. Arbab, Subhash C. Gautam · 2012 · Biochemical and Biophysical Research Communications
89. Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies
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90. Bioassay-guided identification of α-amylase inhibitors in herbal extracts
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91. The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis
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92. The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario
    Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan · 2023 · Medical Oncology
93. Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer
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94. Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo
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95. Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors
    Deheng Chen, Dexiang Guo, Ziqin Yan, Yujun Zhao · 2017 · MedChemComm
96. Synthesis and Biological Evaluation of Novel Olean-28,13β-lactams as Potential Antiprostate Cancer Agents
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97. DIOL Triterpenes Block Profibrotic Effects of Angiotensin II and Protect from Cardiac Hypertrophy
    Rubén Martín, María Miana, Raquel Jurado-López, Ernesto Martínez‐Martínez, Nieves Gómez‐Hurtado, Carmen Delgado, María Visitación Bartolomé, J. Alberto San Román, Cláudia Córdova, Vicente Lahera et al. · 2012 · PLoS ONE
98. Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
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99. Mitotic abnormalities and micronuclei inducing potentials of colchicine and leaf aqueous extracts ofClerodendrum viscosumVent. inAllium ceparoot apical meristem cells
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100. Lupeol as a magical drug
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