Cited by 651Natural product bioactivities and synthesisPhytochemical Studies and BioactivitiesPharmacological Effects of Natural Compounds

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

Liby, Karen T., Yore, Mark M., Sporn, Michael B.·2007·Nature Reviews Cancer

DOI 10.1038/nrc2129

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Abstract

Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs. They are neither conventional cytotoxic agents, nor are they monofunctional drugs that uniquely target single steps in signal transduction pathways. Synthetic oleanane triterpenoids have profound effects on inflammation and the redox state of cells and tissues, as well as being potent anti-proliferative and pro-apoptotic agents. Rexinoids are ligands for the nuclear receptor transcription factors known as retinoid X receptors. Both classes of agents can prevent and treat cancer in experimental animals. These drugs have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti-cancer treatments.

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Suh, N. et al. Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. Clin. Cancer Res. 8, 3270–3275 (2002). The first report of the combination of a rexinoid and a SERM for prevention and treatment of breast cancer.

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Authors: Liby, K. T., Yore, M. M., & Sporn, M. B.
Affiliations: Dartmouth College (US)
Corresponding author: Sporn, Michael B.
ORCID: Liby, Karen T.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2007-04-19
Volume: 7
Issue: 5
Pages: 357-369
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2129
OpenAlex: W2000178617
Cited by: 637
References: 175
Citations by year: 2026: 9 · 2025: 13 · 2024: 23 · 2023: 30 · 2022: 32 · 2021: 23 · 2020: 28 · 2019: 27 · 2018: 15 · 2017: 35 · 2016: 36 · 2015: 44 · 2014: 47 · 2013: 43 · 2012: 48
FWCI: 3.46
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
Keywords: oleanane triterpenoids, rexinoids, cancer prevention, cancer therapy, retinoid X receptor, antiproliferative agents, apoptosis, inflammation, redox state, multi-target drugs, drug synergy
MeSH terms: Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Dose-Response Relationship, Drug, Humans, Neoplasms, Oleanolic Acid, Anticarcinogenic Agents, Retinoid X Receptors, Mice

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

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