The DOI matches its Crossref record; 172 of the 175 references it cites were found in a registry or an index.
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
Abstract
Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs. They are neither conventional cytotoxic agents, nor are they monofunctional drugs that uniquely target single steps in signal transduction pathways. Synthetic oleanane triterpenoids have profound effects on inflammation and the redox state of cells and tissues, as well as being potent anti-proliferative and pro-apoptotic agents. Rexinoids are ligands for the nuclear receptor transcription factors known as retinoid X receptors. Both classes of agents can prevent and treat cancer in experimental animals. These drugs have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti-cancer treatments.
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In the citing paper
“Synthetic triterpenoids (TP), analogues of oleanolic acid, are powerful inhibitors of oxidative stress and cellular inflammatory processes, and thus may be neuroprotective in neurodegeneration.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [181]
In the citing paper
“Synthetic TP compounds are potent inducers of the antioxidant response element (ARE)–Nrf2–Keap1 signaling pathway and are useful in a variety of the cancers including leukemia, multiple myeloma, osteosarcoma, breast and lung cancer181.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [181]
Citations
Cites
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Research works printed but not linked: 1
- Suh, N. et al. Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. Clin. Cancer Res. 8, 3270–3275 (2002). The first report of the combination of a rexinoid and a SERM for prevention and treatment of breast cancer.
Cited by
Sorted by citations
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
“In addition to being potent inducers of ARE genes and anticancer agents, cyano enone inducers exhibit strong anti-inflammatory, hypoglycemic, antihyperlipidemic, antiproliferative, and proapoptotic activities (97, 157).”
BackgroundReactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
“Nrf2 activators such as triterpenoids (CDDO-Im) that target cysteine residues of Keap1 have been used to specifically disrupt Keap1:Nrf2 interactions, thereby promoting Nrf2 nuclear accumulation and leading to Nrf2-target gene induction (247) in Nrf2-sufficient but not in Nrf2-deficient cells in vitro and in vivo, sug…”
Targeting mitochondria for cancer therapy
Fulda, S., Galluzzi, L., & Kroemer, G. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3137 · Cited by 1,678
“Betulinic acid (3b, hydroxy-lup-20(29)-en-28-oic acid) is a natural pentacyclic triterpenoid of the lupane class that is contained in various species throughout the plant kingdo”
BackgroundNRF2 and cancer: the good, the bad and the importance of context
Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067
Self-citationNatural products to drugs: natural product-derived compounds in clinical trials
Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,086
Metadata
- Authors
- Liby, K. T., Yore, M. M., & Sporn, M. B.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Sporn, Michael B.
- ORCID
- Liby, Karen T.
- Venue
- Nature Reviews Cancer
- Published
- 2007-04-19
- Volume
- 7
- Issue
- 5
- Pages
- 357-369
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2000178617
- Cited by
- 637
- References
- 175
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 30 · 2022: 32 · 2021: 23 · 2020: 28 · 2019: 27 · 2018: 15 · 2017: 35 · 2016: 36 · 2015: 44 · 2014: 47 · 2013: 43 · 2012: 48
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Keywords
- oleanane triterpenoids, rexinoids, cancer prevention, cancer therapy, retinoid X receptor, antiproliferative agents, apoptosis, inflammation, redox state, multi-target drugs, drug synergy
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Dose-Response Relationship, Drug, Humans, Neoplasms, Oleanolic Acid, Anticarcinogenic Agents, Retinoid X Receptors, Mice
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