The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Abstract
FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies. Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis. This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer.
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“FBXW7 ubiquitin ligase is a component of the SCF complex and mediates degradation of several cell cycle proteins,158 and its β-isoform is induced by p53.159”
From Census and evaluation of p53 target genes (2017) · cites this paper as [158]
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Cites
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Genome remodelling in a basal-like breast cancer metastasis and xenograft
Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,144
Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis
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Metadata
- Authors
- Welcker, M., & Clurman, B. E.
- Affiliations
- Fred Hutch Cancer Center (US)
- University of Washington (US)
- Corresponding author
- Welcker, Markus
- Venue
- Nature Reviews Cancer
- Published
- 2008-02
- Volume
- 8
- Issue
- 2
- Pages
- 83-93
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2142183096
- Cited by
- 1,084
- References
- 120
- Citations by year
- 2026: 33 · 2025: 34 · 2024: 34 · 2023: 38 · 2022: 53 · 2021: 67 · 2020: 64 · 2019: 69 · 2018: 67 · 2017: 68 · 2016: 74 · 2015: 77 · 2014: 73 · 2013: 82 · 2012: 76
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL084205)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- FBXW7, SCF ubiquitin ligase, tumour suppressor, MYC degradation, cyclin E, notches, c-Jun, chromosomal instability, carcinogenesis, cancer-associated mutations, cell division, cell growth, cell differentiation
- MeSH terms
- F-Box-WD Repeat-Containing Protein 7, Animals, Cell Differentiation, Cell Division, Humans, Models, Biological, Mutation, Neoplasms, Gene Expression Regulation, Neoplastic, Cell Cycle Proteins, Dimerization, Cyclin E, Ubiquitin-Protein Ligases, F-Box Proteins, Cell Proliferation, Mice
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