FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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Deregulated cyclin E induces chromosome instability

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

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Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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Inactivation of hCDC4 can cause chromosomal instability

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Cyclin E in normal and neoplastic cell cycles

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FBXW7/hCDC4 Is a General Tumor Suppressor in Human Cancer

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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The ubiquitin-specific protease USP28 is required for MYC stability

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c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

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Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCFFbw7

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

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Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase

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Avian sarcoma virus 17 carries the jun oncogene.

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

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The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

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DNA Copy Number Losses in Human Neoplasms

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Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

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Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

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SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

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The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling

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A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

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SREBP in signal transduction: cholesterol metabolism and beyond

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Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

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hCDC4 gene mutations in endometrial cancer.

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

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Induction of Mammary Gland Hyperplasia and Carcinomas in Transgenic Mice Expressing Human Cyclin E

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sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteinsPreprint

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BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer

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Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination

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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeastPreprint

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The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling

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Kinase-independent function of cyclin E

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Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

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c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors

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Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase

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Homodimer of Two F-box Proteins βTrCP1 or βTrCP2 Binds to IκBα for Signal-dependent Ubiquitination

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Phosphorylation and Ubiquitination of the Transcription Factor Sterol Regulatory Element-binding Protein-1 in Response to DNA Binding

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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53

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Degradation of the Transcription Factor Gcn4 Requires the Kinase Pho85 and the SCFCDC4Ubiquitin–Ligase Complex

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p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

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