Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
Abstract
This Review deals with recent progress in the immunotherapy of established (pre)malignant disease of viral or non-viral origin by synthetic vaccines capable of inducing robust T-cell responses. The most attractive vaccine compounds are synthetic long peptides (SLP) corresponding to the sequence of tumour viral antigens or tumour-associated non-viral antigens. Crucial to induction of therapeutic T-cell immunity is the capacity of SLP to deliver specific cargo to professional antigen-presenting cells (dendritic cells (DC)). Proper DC activation then induces the therapeutic CD4+ and CD8+ T-cell responses that are associated with regression of established (pre)malignant lesions, including those induced by high-risk human papilloma virus.
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Cross-Presentation, Dendritic Cells, Tolerance and Immunity
Heath, W. R., & Carbone, F. R. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.47 · Cited by 882 · see citing works
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Therapeutic cancer vaccines: Advancements, challenges, and prospects
Fan, T., Zhang, M., Yang, J., Zhu, Z., Cao, W., & Dong, C. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01674-3 · Cited by 597 · see citing works
Speetjens, F. M., Kuppen, P. J. K., Welters, M. J. P., Essahsah, F., Voet van den Brink, A. M. E. G., Lantrua, M. G. K., Valentijn, A. R. P. M., Oostendorp, J., Fathers, L. M., Nijman, H. W., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2227 · Cited by 185 · see citing works
Self-citation
- Authors
- Melief, C. J. M., & van der Burg, S. H.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Melief, Cornelis J.M.
- Venue
- Nature Reviews Cancer
- Published
- 2008-05
- Volume
- 8
- Issue
- 5
- Pages
- 351-360
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2071244674
- Cited by
- 594
- References
- 1
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 17 · 2023: 32 · 2022: 33 · 2021: 38 · 2020: 37 · 2019: 33 · 2018: 34 · 2017: 22 · 2016: 38 · 2015: 38 · 2014: 45 · 2013: 27 · 2012: 40
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- cancer immunotherapy, tumor-associated antigens, dendritic cells, antigen presentation, CD4+ T cell responses, CD8+ T cell responses, high-risk HPV, tumor regression
- MeSH terms
- Animals, Dendritic Cells, Humans, Peptides, Precancerous Conditions, Rabbits, Immunotherapy, Active, Cancer Vaccines, Vaccines, Subunit, Mice
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