The DOI matches its Crossref record; 135 of the 136 references it cites were found in a registry or an index.
p53 and E2f: partners in life and death
Abstract
During tumour development cells sustain mutations that disrupt normal mechanisms controlling proliferation. Remarkably, the Rb-E2f and MDM2-p53 pathways are both defective in most, if not all, human tumours, which underscores the crucial role of these pathways in regulating cell cycle progression and viability. A simple interpretation of the observation that both pathways are deregulated is that they function independently in the control of cell fate. However, a large body of evidence indicates that, in addition to their independent effects on cell fate, there is extensive crosstalk between these two pathways, and specifically between the transcription factors E2F1 and p53, which influences vital cellular decisions. This Review discusses the molecular mechanisms that underlie the intricate interactions between E2f and p53.
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“E2F1 signals positive and negative feedback to p53.225”
From Census and evaluation of p53 target genes (2017) · cites this paper as [225]
Citations
Cites
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A microRNA component of the p53 tumour suppressor network
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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
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Mutant p53: one name, many proteinsPreprint
Freed-Pastor, W. A., & Prives, C. L. (2012) · Genes & Development · doi:10.1101/gad.190678.112 · Cited by 1,290
Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,150
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
Donehower, L. A., Soussi, T., Korkut, A., Liu, Y., Schultz, A., Cardenas, M., Li, X., Babur, Ö., Hsu, T., Lichtarge, O., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.001 · Cited by 724
The role of nuclear lamin B1 in cell proliferation and senescence
Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development · doi:10.1101/gad.179515.111 · Cited by 547
Metadata
- Authors
- Polager, S., & Ginsberg, D.
- Affiliations
- Bar-Ilan University (IL)
- Corresponding author
- Ginsberg, Doron
- ORCID
- Ginsberg, Doron
- Venue
- Nature Reviews Cancer
- Published
- 2009-10
- Volume
- 9
- Issue
- 10
- Pages
- 738-748
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2019562165
- Cited by
- 498
- References
- 136
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 20 · 2023: 23 · 2022: 13 · 2021: 23 · 2020: 18 · 2019: 23 · 2018: 27 · 2017: 35 · 2016: 38 · 2015: 41 · 2014: 43 · 2013: 54 · 2012: 46
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- p53, E2F1, Rb/E2F pathway, MDM2-p53 pathway, pathway crosstalk, cell cycle regulation, cell fate, carcinogenesis, transcription factors, tumor suppressor
- MeSH terms
- Cell Cycle, Cell Survival, Humans, Mutation, Neoplasms, Signal Transduction, Tumor Suppressor Protein p53, Apoptosis, Cell Proliferation, E2F Transcription Factors
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