Cited by 498Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCell death mechanisms and regulation

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p53 and E2f: partners in life and death

Polager, Shirley, Ginsberg, Doron·2009·Nature Reviews Cancer

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Abstract

During tumour development cells sustain mutations that disrupt normal mechanisms controlling proliferation. Remarkably, the Rb-E2f and MDM2-p53 pathways are both defective in most, if not all, human tumours, which underscores the crucial role of these pathways in regulating cell cycle progression and viability. A simple interpretation of the observation that both pathways are deregulated is that they function independently in the control of cell fate. However, a large body of evidence indicates that, in addition to their independent effects on cell fate, there is extensive crosstalk between these two pathways, and specifically between the transcription factors E2F1 and p53, which influences vital cellular decisions. This Review discusses the molecular mechanisms that underlie the intricate interactions between E2f and p53.

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Authors: Polager, S., & Ginsberg, D.
Affiliations: Bar-Ilan University (IL)
Corresponding author: Ginsberg, Doron
ORCID: Ginsberg, Doron
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-10
Volume: 9
Issue: 10
Pages: 738-748
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2718
OpenAlex: W2019562165
Cited by: 498
References: 136
Citations by year: 2026: 7 · 2025: 12 · 2024: 20 · 2023: 23 · 2022: 13 · 2021: 23 · 2020: 18 · 2019: 23 · 2018: 27 · 2017: 35 · 2016: 38 · 2015: 41 · 2014: 43 · 2013: 54 · 2012: 46
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, E2F1, Rb/E2F pathway, MDM2-p53 pathway, pathway crosstalk, cell cycle regulation, cell fate, carcinogenesis, transcription factors, tumor suppressor
MeSH terms: Cell Cycle, Cell Survival, Humans, Mutation, Neoplasms, Signal Transduction, Tumor Suppressor Protein p53, Apoptosis, Cell Proliferation, E2F Transcription Factors

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