Targeting the cancer kinome through polypharmacology

Cited by (714)

Items 601–700 of 714

1. Introduction to Kinase Antitargets
   Mark Munson · 2015 · Methods and principles in medicinal chemistry
2. Chemical Systems Biology Studies of Triple Negative Breast Cancer Cell Lines
   Prson Gautam · 2017 · Työväentutkimus Vuosikirja
3. Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
   Sameer S. Chopra, Anne Jenney, Adam Christopher Palmer, Mario Niepel, Mirra Chung, Caitlin E. Mills, Sindhu Carmen Sivakumaren, Qingsong Liu, Jia-Yun Chen, Clarence Yapp et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
4. Label-free whole-cell phenotypic diagnostics for cancer
   Fang Ye · 2013
5. Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib is driven by off-target Ferrochelatase inhibition
   Yuntao Bai, JY Kim, Laura A. Jayne, Megha Gandhi, Kevin M. Huang, Josie A. Silvaroli, Veronika Sander, Jason M. Prosek, Kenar D. Jhaveri, Sharyn D. Baker et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
6. scRNA-Seq-based drug repurposing targeting idiopathic pulmonary fibrosis (IPF)
   Anika Liu, Joo‐Hyeon Lee, Namshik Han, Andreas Bender · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
7. Special Issue on Network Pharmacology Modeling for Drug Discovery
   Jing Ping Tang · 2023 · Processes
8. Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
   Gregory S. Ducker · 2013 · eScholarship (California Digital Library)
9. Ets1 as a Target of MicroRNA-1 in Cutaneous Squamous Cell Carcinoma
   Dustin L. Gable · 2011 · The Knowledge Bank (The Ohio State University)
10. Applications of Rule‐Based Methods to Data Mining of Polypharmacology Data Sets
    Nathalie Jullian, Yannic Tognetti, Mohammad Afshar · 2013 · Methods and principles in medicinal chemistry
11. Experimental and Computational Analysis of Epidermal Growth Factor Receptor Pathway Phosphorylation Dynamics
    Laura B. Kleiman · 2010 · DSpace@MIT (Massachusetts Institute of Technology)
12. Terapie molecolari mirate e antiangiogeniche nel trattamento dei glioblastomi
    François Ducray, Ahmed Idbaïh · 2012 · EMC - Neurologia
13. An Empirical Comparison of Platt Calibration and Inductive Confidence Machines for Predictions in Drug Discovery
    Nikil Wale · 2010 · IEEE ... International Conference on Data Mining workshops
14. Development and application of genus-specific peptide arrays for kinome analysis
    Ryan J. Arsenault · 2011 · HARVEST (University of Saskatchewan)
15. Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells
    Sara Ståhl · 2011 · Figshare
16. Development of Species‐ and Process‐Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease
    Ryan J. Arsenault, Brett Trost, ANTHONY J. KUSALIK, Scott Napper · 2015
17. Integrative Systems Approaches Towards Brain Pharmacology and Polypharmacology
    Rheinischen Friedrich-Wilhelms-Universität Bonn · 2013
18. Enhancing physicochemical properties through synthesis and formulation of piclamilast- and lapatinib-derived analogs
    Jennifer L. Woodring · 2014
19. Selected genes involved in GIST evolution from indolent to advanced tumours
    Anna Quattrone · 2015
20. Thérapies moléculaires ciblées et antiangiogéniques dans le traitement des glioblastomes
    François Ducray, Ahmed Idbaïh · 2012 · Encyclopédie médico-chirurgicale. Neurologie
21. The Future of Kinase Drug Discovery
    Carlos Garcı́a-Echeverrı́a · 2011 · Royal Society of Chemistry eBooks
22. The Mechanisms and Kinetics of Protein Kinase Inhibitors
    Walter H.J. Ward · 2011 · Royal Society of Chemistry eBooks
23. Engineering Small Molecule Responsive Split Protein Kinases
    Javier Castillo‐Montoya, Indraneel Ghosh · 2017 · Methods in molecular biology
24. Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: Lessons learned from HIV-1 protease inhibition
    Mala L. Radhakrishnan, Yang Shen, Bruce Tidor · 2015 · PMC
25. Protein Domain Level Cancer Drug Targets in the Network of MAPK Pathways
    MD Aksam V.K., V.M. Chandrasekaran, Sundaramurthy Pandurangan · 2018 · IEEE Transactions on Computational Biology and Bioinformatics
26. Targeting the Triple-Negative Breast Cancer Kinome with Chemical Proteomics
    Martin C. Whittle · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
27. [Special Issue for Honor Award dedicating to Prof Kimito Funatsu]Exploring Polypharmacology and Molecular Promiscuity
    Jürgen Bajorath · 2019 · Journal of Computer Aided Chemistry
28. US FDA‐Approved Small‐Molecule Kinase Inhibitors for Cancer Therapy
    Mingfeng Yu, Solomon Tadesse, Shudong Wang · 2021 · Wiley eBooks
29. Structure‐Guided Design of G‐Protein‐Coupled Receptor Polypharmacology
    Stefanie Kampen, Duc Duy Vo, Xiaoqun Zhang, Nicolas Panel, Yunting Yang, Mariama Jaiteh, Pierre G. Matricon, Per Svenningsson, Jose Manuel Brea, Marı́a Isabel Loza et al. · 2021 · Angewandte Chemie
30. Evaluating the Therapeutic Viability of Bacterially Expressed Human TLK1B-Kinase Domain for Cancer Drug Design
    Delna Johnson, Javeena Hussain, Siddhant Bhoir, Parul Sahsrawat, Tanya Hans, C. Vaishali, Vijay Thiruvenkatam, Sivapriya Kirubakaran · 2022 · Research Square
31. Peer Review #3 of "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice (v0.1)"
    2013 · PeerJ
32. Peer Review #2 of "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice (v0.2)"
    2013 · PeerJ
33. Peer Review #2 of "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice (v0.1)"
    2013 · PeerJ
34. Faculty Opinions recommendation of Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
    Giancarlo Vecchio, Rosa Marina Melillo · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
35. Implicación de las quinasas humanas VRK1 y VRK2 en las rutas de respuesta a daño genético y apoptosis
    Diana M. Monsalve · 2014 · Gredos (University of Salamanca)
36. Peer Review #1 of "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice (v0.1)"
    2013 · PeerJ
37. PDGF
    Carl‐Henrik Heldin · 2014 · Springer eBooks
38. Peer Review #1 of "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice (v0.2)"
    2013 · PeerJ
39. PDGF
    Carl‐Henrik Heldin · 2017 · Springer eBooks
40. Data from Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition
    Cara Abecunas, Christopher E. Whitehead, Elizabeth K. Ziemke, Douglas G. Baumann, Christy L. Frankowski-McGregor, Judith S. Sebolt, Mohammad Fallahi‐Sichani · 2023
41. Data from A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy
    Fushun Fan, Pei Liu, Rudi Bao, Jian Chen, Minhua Zhou, Zhenxian Mo, Yaru Ma, Haiqi Liu, Yiping Zhou, Xiong Cai et al. · 2023
42. Emerging roles for phospholipase A2 superfamily and their metabolites in carcinogenesis
    Jalal Pourahmad, Abdollah Arjmand · 2023 · Elsevier eBooks
43. All the mutations that are fit to die
    Emma Gebauer, Markus A. Seeliger · 2024 · Cell chemical biology
44. Additional file 4 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Xiao-Ting Mu, Su, Bing, Lu Gao, Dongfang Zhang · 2020 · Figshare
45. Additional file 1 of Explicit representation of protein activity states significantly improves causal discovery of protein phosphorylation networks
    Liu, Jinling, Xiaojun Ma, Gregory F. Cooper, Xinghua Lu · 2020 · Figshare
46. Additional file 5 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Xiao-Ting Mu, Su, Bing, Lu Gao, Dongfang Zhang · 2020 · Figshare
47. Introduction
    Jürgen Bajorath · 2024 · Wiley eBooks
48. Advancing Drug Discovery through Integrative Computational Models and AI Technologies
    Stefano Piotto, Lucia Sessa, Eugenio Sottile, Arkadeep Sarkar, Simona Concilio · 2025 · Drug repurposing
49. Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signaling
    Vasudha Tandon, Alessandra Fistrovich, Joaquina Nogales, Febe Ferro, Samantha Rokey, Carly R. Cabel, Amy Dunne Miller, Mary Yagel, Christina Duncan, Aditi Mandar Atmasidha et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
50. Quantification of Conformational Changes of Kinase Regulators, Kinases, and Regulator–Kinase Complexes Using the TSR Algorithm
    Tarikul I. Milon, Poorya Khajouie, Feng Chen, Tyler A Borel, Kathleen D. Knierim, Vijay V. Raghavan, Wu Xu · 2025 · Methods in molecular biology
51. Additional file 2 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Dongfang Zhang · 2020 · Figshare
52. Additional file 7 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Dongfang Zhang · 2020 · Figshare
53. Additional file 6 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Zhang, Dong-Fang · 2020 · Figshare
54. Additional file 3 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Dongfang Zhang · 2020 · Figshare
55. Additional file 1 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Dongfang Zhang · 2020 · Figshare
56. Additional file 8 of Identification of the anti-breast cancer targets of triterpenoids in Liquidambaris Fructus and the hints for its traditional applications
    Qian, Ping, Mu, Xiao-Ting, Su, Bing, Gao, Lu, Zhang, Dong-Fang · 2020 · Figshare
57. kinCSM-RTK: Machine Learning-Based Screening of Receptor Tyrosine Kinase Inhibitors in Drug Discovery
    Adam Serghini, Yunzhuo Zhou, Yoochan Myung, Alex G. C. de Sá, Stephanie Portelli, David Benjamin Ascher · 2025 · Journal of Chemical Information and Modeling
58. Theranostic of neutrophilization nanoparticles
    Daqian Sun, Bingrun Song, Weikai Sun, Anning Li, Zhiliang Gao, Dexin Yu · 2026 · Progress in Materials Science
59. The pyrazolo[3,4-d]pyrimidine derivative CLM24 has an antineoplastic effect in aggressive dedifferentiated thyroid cancer in vitro
    Silvia Martina Ferrari, Francesca Ragusa, Giusy Elia, Valeria Mazzi, Eugenia Balestri, Chiara Botrini, Licia Rugani, Simona Piaggi, Concettina La Motta, Giulia Antonelli et al. · 2026 · Endocrine
60. Molecular mechanisms of aneuploidy-mediated stress-resistance
    Andrei Kucharavy · 2017 · theses.fr (ABES)
61. Direct coupling and protective activation of DRP1 by the DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cells
    Lingling Ding, Changtian Yin, Yehao Guo, Qiang Geng, Wanwan He, Yawen Guo, Jinpeng Wen, Aoni Zhou, Jieyu Luo, Xinxin Ren et al. · 2026 · Cell Death and Disease
62. Targeting Complexity：Scientific Foundation and Frontiers of Multi-target Drug Discovery
    Kongkai Zhu, Xin Wen, Jin‐Peng Sun · 2026 · 中国科学基金
63. Synthesis, ADMET, DFT analysis, molecular docking, and multitarget bioactivity of a 2,5-dihydroxybenzaldehyde Schiff base: Insights into antioxidant, anti-inflammatory, and selective anticancer activity
    Amina Alouache, Abdellatif Ben kaida, Nadjib Benosmane, Taklit Maddi, Marı́a C. Gutiérrez, M. Luisa Ferrer, Francisco del Monte · 2026 · Journal of Molecular Structure
64. Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy
    Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Alejandro Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jönsson, Helgi B. Schiöth · 2026 · British Journal of Pharmacology
65. Expression pattern, functional characteristics and prognostic significance of NLGN1 gene in nasopharyngeal carcinoma: a comprehensive multi-omics analysis
    Yi Nan Liu, Yan Yan Fan · 2026 · Discover Oncology
66. Role of the immune receptor CD47 in mouse model of non-infectious uveitis
    Yueshen Che · 2026 · theses.fr (ABES)
67. How many protein pairs can we chemically target?
    Maria J. Falaguera, Tudor Ionel Oprea, Jordi Mestres · 2026 · Drug Discovery Today
68. Chemical Approaches for Developing Potent Kinase Inhibitors and DNA-Targeting Agents in Cancer Therapy
    Pranit Hemant Bagde, Bijayeeta Deb, Harshita Shrivastava, Hem Chandra Jha · 2026 · Springer eBooks
69. Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC
    Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura et al. · 2026 · Cancer Science
70. PKIDB-informed molecular profiling improves reproducible prediction of cancer kinase-inhibitor response
    Miao Liu, Jiayang Song, Xianbin Liu, Linlin Zhao, Yu Xiong · 2026 · Frontiers in Pharmacology
71. Polypharmacological target-aware molecule generation
    Kehan Wu, Wei Zhang, Han Guo, Renhe Liu, Yu Shi, Peiran Jin, Haiguang Liu, Enhong Chen, Tao Qin, Zequn Liu et al. · 2026 · Bioinformatics
72. HuKSA: A Machine-Learning-Based Framework for Predicting Human Kinome Selectivity and Polypharmacology
    Mohammad Umar Saeed, Arunabh Choudhury, Yash Mathur, Md. Imtaiyaz Hassan · 2026 · Journal of Molecular Biology
73. Breast cancer and kinase modulation: Nutraceuticals as targeted therapeutics for HER2, PI3K/Akt, and MAPK pathways
    Anam Ilyas, Shaheen Ali, Ramsha Parveen, Alfisha Mustafa, Shagufi Nazar, Md Fazlur Rahman, Nida Alam, Asif Husain, Sana Tanweer, Ozair Alam · 2026 · Elsevier eBooks
74. BindingDB Entry 50047518: Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.
    BindingDB · 2017 · UC San Diego
75. BindingDB Entry 50034019: Comprehensive analysis of kinase inhibitor selectivity.
    BindingDB · 2012 · UC San Diego
76. BindingDB Entry 50000196: A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.
    BindingDB · 2019 · UC San Diego
77. BindingDB Entry 50047605: Novel approaches to map small molecule-target interactions.
    BindingDB · 2017 · UC San Diego
78. BindingDB Entry 50033331: Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.
    BindingDB · 2011 · UC San Diego
79. BindingDB Entry 50002006: Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
    BindingDB · 2020 · UC San Diego
80. BindingDB Entry 50043566: Polypharmacology - foe or friend?
    BindingDB · 2014 · UC San Diego
81. BindingDB Entry 50034175: Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.
    BindingDB · 2012 · UC San Diego
82. BindingDB Entry 50043331: Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.
    BindingDB · 2014 · UC San Diego
83. BindingDB Entry 50006855: Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.
    BindingDB · 2021 · UC San Diego
84. BindingDB Entry 50045521: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
    BindingDB · 2016 · UC San Diego
85. BindingDB Entry 50033622: Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment.
    BindingDB · 2012 · UC San Diego
86. BindingDB Entry 50002905: Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts.
    BindingDB · 2020 · UC San Diego
87. BindingDB Entry 50002223: Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.
    BindingDB · 2020 · UC San Diego
88. BindingDB Entry 50022379: Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer.
    BindingDB · 2025 · UC San Diego
89. BindingDB Entry 50040035: Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.
    BindingDB · 2013 · UC San Diego
90. BindingDB Entry 50013233: From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.
    BindingDB · 2022 · UC San Diego
91. BindingDB Entry 50007213: Privileged Structures and Polypharmacology within and between Protein Families.
    BindingDB · 2021 · UC San Diego
92. BindingDB Entry 50043100: Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.
    BindingDB · 2014 · UC San Diego
93. BindingDB Entry 50043098: Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.
    BindingDB · 2014 · UC San Diego
94. BindingDB Entry 50022582: Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine.
    BindingDB · 2025 · UC San Diego
95. BindingDB Entry 50017646: Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity.
    BindingDB · 2023 · UC San Diego
96. BindingDB Entry 50011917: Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
    BindingDB · 2022 · UC San Diego
97. BindingDB Entry 50001450: Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer.
    BindingDB · 2020 · UC San Diego
98. BindingDB Entry 50047644: Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K).
    BindingDB · 2017 · UC San Diego
99. BindingDB Entry 50048218: Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors.
    BindingDB · 2018 · UC San Diego
100. BindingDB Entry 50033723: Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.
     BindingDB · 2012 · UC San Diego