The tumorigenicity of human embryonic and induced pluripotent stem cells
Abstract
The unique abilities of human pluripotent stem cells to self-renew and to differentiate into cells of the three germ layers make them an invaluable tool for the future of regenerative medicine. However, the same properties also make them tumorigenic, and therefore hinder their clinical application. Hence, the tumorigenicity of human embryonic stem cells (HESCs) has been extensively studied. Until recently, it was assumed that human induced pluripotent stem cells (HiPSCs) would behave like their embryonic counterparts in respect to their tumorigenicity. However, a rapidly accumulating body of evidence suggests that there are important genetic and epigenetic differences between these two cell types, which seem to influence their tumorigenicity.
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Critical safety concerns remain regarding the use of viral vectors and the potential for teratoma formation, limiting the clinical application of iPSCs.
“However, critical safety concerns remain regarding the use of viral vectors and the potential for teratoma formation, limiting the clinical application of iPSCs [197,216].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [216]
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Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine
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Recent advances in liver engineering with decellularized scaffold
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“However, critical safety concerns remain regarding the use of viral vectors and the potential for teratoma formation, limiting the clinical application of iPSCs [197,216].”
BackgroundRole of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy
Li, Y., & Darabi, R. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30164 · Cited by 16 · see citing works
- Authors
- Ben-David, U., & Benvenisty, N.
- Affiliations
- Hebrew University of Jerusalem (IL)
- ORCID
- Benvenisty, Nissim
- Venue
- Nature Reviews Cancer
- Published
- 2011-03-10
- Volume
- 11
- Issue
- 4
- Pages
- 268-277
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1967467247
- Cited by
- 889
- References
- 8
- Citations by year
- 2026: 28 · 2025: 25 · 2024: 36 · 2023: 47 · 2022: 40 · 2021: 67 · 2020: 47 · 2019: 66 · 2018: 62 · 2017: 69 · 2016: 74 · 2015: 86 · 2014: 80 · 2013: 67 · 2012: 67
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- tumorigenicity, human embryonic stem cells, induced pluripotent stem cells, pluripotency, self-renewal, germ layer differentiation, genetic differences, epigenetic variation, clinical translation
- MeSH terms
- Cell Differentiation, Humans, Neoplasms, Regenerative Medicine, Embryonic Stem Cells, Induced Pluripotent Stem Cells, Epigenomics
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