The Role of Myc-Induced Protein Synthesis in Cancer

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MYC oncogenes and human neoplastic disease

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

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Drosophila myc Regulates Cellular Growth during Development

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dMyc Transforms Cells into Super-Competitors

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

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The transcriptional program of a human B cell line in response to Myc.

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C-Myc 5′ untranslated region contains an internal ribosome entry segment

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Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

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Identification and Characterization of a Novel Cell Cycle–Regulated Internal Ribosome Entry Site

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Ribosomal protein L24 defect in Belly spot and tail (<i>Bst</i>), a mouse<i>Minute</i>

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Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

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Identification of c-myc responsive genes using rat cDNA microarray.

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14-3-3σ controls mitotic translation to facilitate cytokinesis

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Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

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MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

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A role for c-Myc in the regulation of ribosomal RNA processing

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Cell-cycle-dependent translational control.

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Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

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Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation

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The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

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Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

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Modulation of T‐lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

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Activation by c-Myc of transcription by RNA polymerases I, II and III

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Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels

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CDK11p58 is required for the maintenance of sister chromatid cohesion

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The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival

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Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2α

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A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors

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Loss of Protooncogene c-Myc Function Impedes G1 Phase Progression Both before and after the Restriction Point

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Experimental phenocopy of a Minute maternal-effect mutation alters blastoderm determination in embryos of Drosophila melanogaster

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c-Myc overexpression increases cell size and impairs cartilage differentiation during chick limb development.

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Molecular Genetics of Colorectal Cancer

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Transcriptional Amplification in Tumor Cells with Elevated c-Myc

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MYC, Metabolism, and Cancer

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The tumorigenicity of human embryonic and induced pluripotent stem cells

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Activation of mTORC2 by Association with the Ribosome

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The spliceosome is a therapeutic vulnerability in MYC-driven cancer

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ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

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Translational Control in Cancer EtiologyPreprint

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MYC and metabolism on the path to cancer

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Biomolecular Condensates and Cancer

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Ribosome biogenesis in disease: new players and therapeutic targets

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

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The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc

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AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

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Targeting the nucleolus for cancer intervention

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Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications

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Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review

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Molecular mechanisms of natural killer cell activation in response to cellular stress

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Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

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Myc proteins as therapeutic targets

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Regulation of let-7 and its target oncogenes (Review)

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Development of a stress response therapy targeting aggressive prostate cancer

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Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

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Polyamine synthesis as a target of MYC oncogenes

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Potential of Stem Cell-Based Therapy for Ischemic Stroke

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MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours

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Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

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Widespread Translational Remodeling during Human Neuronal Differentiation

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Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene

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Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling

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The ribosome, (slow) beating heart of cancer (stem) cell

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SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

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Ribosome biogenesis and cancer

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The cancerous translation apparatus

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p53 -Dependent and -Independent Nucleolar Stress Responses

Olausson, K. H., Nistér, M., & Lindström, M. S. (2012) · Cells · doi:10.3390/cells1040774 · Cited by 116 · see citing works

Role of let-7 family microRNA in breast cancer

Thammaiah, C. K., & Jayaram, S. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.10.003 · Cited by 110 · see citing works

MYC and Transcription ElongationPreprint

Rahl, P. B., & Young, R. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a020990 · Cited by 112 · see citing works

A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

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Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth

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c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

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Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

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MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and IIIPreprint

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eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

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Changes in ribosome biogenesis may induce cancer by down-regulating the cell tumor suppressor potential

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Translation factors and ribosomal proteins control tumor onset and progression: how?

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Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward

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Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma

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Regulation of Nucleolar Activity by MYC

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AKT signalling is required for ribosomal RNA synthesis and progression of E μ‐Myc B ‐cell lymphoma in vivo

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Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/β-Catenin Pathway

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Review The Role of Myc-Induced Protein Synthesis in Cancer

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Myc, Oncogenic Protein Translation, and the Role of Polyamines

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Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer

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Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

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