Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Expression of a single transfected cDNA converts fibroblasts to myoblasts

Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388 · see citing works

Reprogramming of human somatic cells to pluripotency with defined factors

Park, I.-H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H.-G., Ince, T., Lerou, P., Lensch, M., & Daley, G. Q. (2008) · Nature · doi:10.1038/nature06534 · Cited by 3,028 · see citing works

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

5'-Triphosphate RNA Is the Ligand for RIG-I

Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474 · see citing works

Human induced pluripotent stem cells free of vector and transgene sequences

Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I. I., & Thomson, J. A. (2009) · Science · doi:10.1126/science.1172482 · Cited by 2,386 · see citing works

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210 · see citing works

A ROCK inhibitor permits survival of dissociated human embryonic stem cells

Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S.-I., Muguruma, K., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1310 · Cited by 2,055 · see citing works

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

Okita, K., Nakagawa, M., Hong, H., Ichisaka, T., & Yamanaka, S. (2008) · Science · doi:10.1126/science.1164270 · Cited by 2,002 · see citing works

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.200 · Cited by 1,930 · see citing works

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

Kim, D., Kim, C.-H., Moon, J.-I., Chung, Y.-G., Chang, M.-Y., Han, B.-S., Ko, S., Yang, E., Cha, K. Y., Lanza, R., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.005 · Cited by 1,814 · see citing works

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Woltjen, K., Michael, I. P., Mohseni, P., Desai, R., Mileikovsky, M., Hämäläinen, R. H., Cowling, R. A., Wang, W., Liu, P., Gertsenstein, M., et al. (2009) · Nature · doi:10.1038/nature07863 · Cited by 1,810 · see citing works

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

Zhou, H., Wu, S., Joo, J. Y., Zhu, S., Han, D. W., Lin, T., Trauger, S., Bien, G., Yao, S., Zhu, Y., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.005 · Cited by 1,788 · see citing works

Induced pluripotent stem cells generated without viral integration

Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., & Hochedlinger, K. (2008) · Science · doi:10.1126/science.1162494 · Cited by 1,683 · see citing works

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M. E., Chen, A. E., & Melton, D. (2008) · Nature Biotechnology · doi:10.1038/nbt1418 · Cited by 1,682 · see citing works

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

Randall, R. E., & Goodbourn, S. (2007) · Journal of General Virology · doi:10.1099/vir.0.83391-0 · Cited by 1,559 · see citing works

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

FUSAKI, N., BAN, H., NISHIYAMA, A., SAEKI, K., & HASEGAWA, M. (2009) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.85.348 · Cited by 1,411 · see citing works

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

Kaji, K., Norrby, K., Paca, A., Mileikovsky, M., Mohseni, P., & Woltjen, K. (2009) · Nature · doi:10.1038/nature07864 · Cited by 1,252 · see citing works

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works

Generation of human induced pluripotent stem cells from dermal fibroblasts

Lowry, W. E., Richter, L., Yachechko, R., Pyle, A. D., Tchieu, J., Sridharan, R., Clark, A. T., & Plath, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711983105 · Cited by 1,041 · see citing works

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

Hu, B., Weick, J. P., Yu, J., Ma, L., Zhang, X., Thomson, J. A., & Zhang, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910012107 · Cited by 1,007 · see citing works

Direct cell reprogramming is a stochastic process amenable to acceleration

Hanna, J. H., Saha, K., Pando, B., van Zon, J. S., Lengner, C. J., Creyghton, M. P., van Oudenaarden, A., & Jaenisch, R. (2009) · Nature · doi:10.1038/nature08592 · Cited by 1,006 · see citing works

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

Utikal, J., Polo, J., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J., & Hochedlinger, K. (2009) · Nature · doi:10.1038/nature08285 · Cited by 896 · see citing works

Variation in the safety of induced pluripotent stem cell lines

Miura, K., Okada, Y., Aoi, T., Okada, A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1554 · Cited by 870 · see citing works

Generation of Destabilized Green Fluorescent Protein as a Transcription Reporter

Li, X., Zhao, X., Fang, Y., Jiang, X., Duong, T., Fan, C., Huang, C.-C., & Kain, S. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34970 · Cited by 846 · see citing works

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., & Yamanaka, S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.001 · Cited by 757 · see citing works

A nonviral minicircle vector for deriving human iPS cells

Jia, F., Wilson, K. D., Sun, N., Gupta, D. M., Huang, M., Li, Z., Panetta, N. J., Chen, Z. Y., Robbins, R. C., Kay, M. A., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1426 · Cited by 734 · see citing works

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works

Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

Chadwick, K., Wang, L., Li, L., Menéndez, P. R., Murdoch, B., Rouleau, A., & Bhatia, M. (2003) · Blood · doi:10.1182/blood-2003-03-0832 · Cited by 605 · see citing works

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

Chan, E., Ratanasirintrawoot, S., Park, I.-H., Manos, P. D., Loh, Y., Huo, H.-G., Miller, J. D., Hartung, O., Rho, J., Ince, T., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1580 · Cited by 529 · see citing works

Toll-like Receptors and Type I Interferons

Uematsu, S., & Akira, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700009200 · Cited by 497 · see citing works

Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

Symons, J. A., Alcamı́, A., & Smith, G. L. (1995) · Cell · doi:10.1016/0092-8674(95)90076-4 · Cited by 491 · see citing works

Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells

Van Tendeloo, V. F. I., Ponsaerts, P., Lardon, F., Nijs, G., Lenjou, M., Van Broeckhoven, C., Van Bockstaele, D. R., & Berneman, Z. N. (2001) · Blood · doi:10.1182/blood.v98.1.49 · Cited by 468 · see citing works

Antiviral Signaling Through Pattern Recognition Receptors

Kawai, T., & Akira, S. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvm032 · Cited by 452 · see citing works

Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration

Shea, K. L., Xiang, W., LaPorta, V. S., Licht, J. D., Keller, C., Basson, M. A., & Brack, A. S. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.12.015 · Cited by 351 · see citing works

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

Papapetrou, E. P., Tomishima, M. J., Chambers, S. M., Mica, Y., Reed, E., Menon, J., Tabar, V., Mo, Q., Studer, L., & Sadelain, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904825106 · Cited by 286 · see citing works

Polycistronic Lentiviral Vector for “Hit and Run” Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells

Chang, C.-W., Lai, Y.-S., Pawlik, K. M., Liu, K.-M., Sun, C.-W., Li, C., Schoeb, T., & Townes, T. (2009) · Stem Cells · doi:10.1002/stem.39 · Cited by 229 · see citing works

Dynamic single-cell imaging of direct reprogramming reveals an early specifying event

Smith, Z. D., Nachman, I., Regev, A., & Meissner, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1632 · Cited by 205 · see citing works

HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response

Weissman, D., Ni, H., Scales, D. A., Dude, A., Capodici, J., McGibney, K., Abdool, A. J., Isaacs, S. N., Cannon, G., & Karikó, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4710 · Cited by 178 · see citing works

[4] Synthesis of long, capped transcripts in Vitro by SP6 and T7 RNA polymerases

Yisraeli, J. K., & Melton, D. A. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(89)80090-4 · Cited by 156 · see citing works

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

Uzri, D., & Gehrke, L. (2009) · Journal of Virology · doi:10.1128/jvi.02449-08 · Cited by 155 · see citing works

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

Nallagatla, S. R., & Bevilacqua, P. C. (2008) · RNA · doi:10.1261/rna.1007408 · Cited by 137 · see citing works

Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.

Karikó, K., & Weissman, D. (2007) · PubMed · Cited by 130 · see citing works

Pluripotency: Toward a gold standard for human ES and iPS cells

Smith, K. P., Luong, M. X., & Stein, G. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21681 · Cited by 126 · see citing works

Cationic lipid-mediated transfection in vitro and in vivo

Audouy, D. H. S. (2001) · Molecular Membrane Biology · doi:10.1080/09687680110057237 · Cited by 101 · see citing works

A brilliant disguise for self RNA: 5’-end and internal modifications of primary transcripts suppress elements of innate immunity

Nallagatla, S. R., Toroney, R., & Bevilacqua, P. C. (2008) · RNA Biology · doi:10.4161/rna.5.3.6839 · Cited by 78 · see citing works

Cationic lipid-mediated transfection in vitro and in vivo

Audouy, S. A. L., & Hoekstra, D. (2001) · Molecular Membrane Biology · doi:10.1080/713816122 · Cited by 78 · see citing works

Synthetic Messenger RNA as a Tool for Gene Therapy

Rabinovich, P. M., Komarovskaya, M., Ye, Z.-J., Imai, C., Campana, D., Bahceci, E., & Weissman, S. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.1027 · Cited by 73 · see citing works

Chimeric Receptor mRNA Transfection as a Tool to Generate Antineoplastic Lymphocytes

Rabinovich, P., Komarovskaya, M., Wrzesinski, S. H., Alderman, J. L., Budak-Alpdogan, T., Karpikov, A., Guo, H., Flavell, R., Cheung, N.-K. V., Weissman, S., et al. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.068 · Cited by 62 · see citing works

Optimized transfection of mRNA transcribed from a d(A/T)100 tail-containing vector

Elango, N., Elango, S., Shivshankar, P., & Katz, M. S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.067 · Cited by 57 · see citing works

Simultaneous Activation of Viral Antigen-specific Memory CD4+ and CD8+ T-cells Using mRNA-electroporated CD40-activated Autologous B-cells

den Bosch, G. A. V., Gulck, E. R. V., Ponsaerts, P., Nijs, G., Lenjou, M., Apers, L., Kint, I., Heyndríckx, L., Vanham, G. L., Bockstaele, D. R. V., et al. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000210385.48327.1e · Cited by 14 · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

A more efficient method to generate integration-free human iPS cells

Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K.-I., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1591 · Cited by 2,061 · see citing works

Induced pluripotent stem cell technology: a decade of progress.

Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525 · see citing works

Somatic coding mutations in human induced pluripotent stem cells

Gore, A., Li, Z., Fung, H.-L., Young, J. E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M. A., Kiskinis, E., et al. (2011) · Nature · doi:10.1038/nature09805 · Cited by 1,273 · see citing works

Heart regeneration

Laflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,231 · see citing works

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

Anokye‐Danso, F., Trivedi, C. M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P. J., Epstein, J. A., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.001 · Cited by 1,206 · see citing works

Gene therapy clinical trials worldwide to 2012 – an update

Ginn, S., Alexander, I. E., Edelstein, M. L., Abedi, M. R., & Wixon, J. (2013) · Journal of Gene Medicine · doi:10.1002/jgm.2698 · Cited by 807 · see citing works

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Song, K., Nam, Y., Luo, X., Qi, X., Tan, W. H., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,141 · see citing works

The promise of induced pluripotent stem cells in research and therapy

Robinton, D., & Daley, G. (2012) · Nature · doi:10.1038/nature10761 · Cited by 1,152 · see citing works

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Squires, J. E., Patel, H. R., Nousch, M., Sibbritt, T., Humphreys, D. T., Parker, B. J., Suter, C. M., & Preiß, T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks144 · Cited by 1,011 · see citing works

Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

Bock, C., Kiskinis, E., Verstappen, G., Gu, H., Boulting, G., Smith, Z. D., Ziller, M., Croft, G. F., Amoroso, M. W., Oakley, D. H., et al. (2011) · Cell · doi:10.1016/j.cell.2010.12.032 · Cited by 1,009 · see citing works

Copy number variation and selection during reprogramming to pluripotency

Hussein, S. M. I., Batada, N., Vuoristo, S., Ching, R., Autio, R., Närvä, E., Ng, S., Sourour, M., Hämäläinen, R., Olsson, C., et al. (2011) · Nature · doi:10.1038/nature09871 · Cited by 992 · see citing works

RNA N 6 -methyladenosine methylation in post-transcriptional gene expression regulationPreprint

Yue, Y., Liu, J., & He, C. (2015) · Genes & Development · doi:10.1101/gad.262766.115 · Cited by 918 · see citing works

Gene therapy clinical trials worldwide to 2017: An update

Ginn, S. L., Amaya, A. K., Alexander, I. E., Edelstein, M., & Abedi, M. R. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3015 · Cited by 903 · see citing works

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Karikó, K., Muramatsu, H., Ludwig, J., & Weissman, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr695 · Cited by 898 · see citing works

mRNA capping: biological functions and applications

Ramanathan, A., Robb, G. B., & Chan, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw551 · Cited by 892 · see citing works

The tumorigenicity of human embryonic and induced pluripotent stem cells

Ben-David, U., & Benvenisty, N. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3034 · Cited by 889 · see citing works

In vitro and ex vivo strategies for intracellular delivery

Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885 · see citing works

A decade of transcription factor-mediated reprogramming to pluripotency

Takahashi, K., & Yamanaka, S. (2016) · Nature reviews. Molecular cell biology · doi:10.1038/nrm.2016.8 · Cited by 815 · see citing works

Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014)

Chen, C., Dubin, R., & Kim, M. C. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.920813 · Cited by 857 · see citing works

Induced Pluripotent Stem Cells: Past, Present, and Future

Yamanaka, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.005 · Cited by 846 · see citing works

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3545 · Cited by 837 · see citing works

Induced pluripotency: history, mechanisms, and applicationsPreprint

Stadtfeld, M., & Hochedlinger, K. (2010) · Genes & Development · doi:10.1101/gad.1963910 · Cited by 827 · see citing works

Knocking down disease: a progress report on siRNA therapeutics

Wittrup, A., & Lieberman, J. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3978 · Cited by 810 · see citing works

Tools for translation: non-viral materials for therapeutic mRNA delivery

Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799 · see citing works

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Sellgren, C. M., Gracias, J., Watmuff, B., Biag, J. D., Thanos, J. M., Whittredge, P. B., Fu, T., Worringer, K. A., Brown, H. E., Wang, J. P., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0334-7 · Cited by 784 · see citing works

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777 · see citing works

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

Miyoshi, N., Ishii, H., Nagano, H., Haraguchi, N., Dewi, D. L., Kano, Y., Nishikawa, S., Tanemura, M., Mimori, K., Tanaka, F., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.05.001 · Cited by 756 · see citing works

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 748 · see citing works

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733 · see citing works

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

Lee, A. S., Tang, C. Z., Rao, M. S., Weissman, I. L., & Wu, J. C. (2013) · Nature Medicine · doi:10.1038/nm.3267 · Cited by 720 · see citing works

The epitranscriptome beyond m6A

Wiener, D., & Schwartz, S. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00295-8 · Cited by 717 · see citing works

N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Andries, O., Mc Cafferty, S., De Smedt, S. C., Weiss, R., Sanders, N. N., & Kitada, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.051 · Cited by 701 · see citing works

Gene regulation in the immune system by long noncoding RNAs

Chen, Y. G., Satpathy, A. T., & Chang, H. Y. (2017) · Nature Immunology · doi:10.1038/ni.3771 · Cited by 686 · see citing works

Bright and stable near-infrared fluorescent protein for in vivo imaging

Filonov, G. S., Piatkevich, K. D., Ting, L.-M., Zhang, J., Kim, K., & Verkhusha, V. V. (2011) · Nature Biotechnology · doi:10.1038/nbt.1918 · Cited by 682 · see citing works

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646 · see citing works

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Mannion, N., Greenwood, S. M., Young, R., Cox, S. L., Brindle, J., Read, D. F., Nellåker, C., Vesely, C., Ponting, C. P., McLaughlin, P. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.041 · Cited by 644 · see citing works

Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses

Bahl, K., Senn, J. J., Yuzhakov, O., Bulychev, A., Brito, L. A., Hassett, K. J., Laska, M. E., Smith, M., Almarsson, Ö., Thompson, J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.035 · Cited by 642 · see citing works

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Patsch, C., Meylan, L. C., Thoma, E., Urich, E., Heckel, T., O’Sullivan, J., Grainger, S. J., Kapp, F., Sun, L., Christensen, K., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3205 · Cited by 628 · see citing works

Developing mRNA-vaccine technologies

Schlake, T., Thess, A., Fotin-Mleczek, M., & Kallen, K.-J. (2012) · RNA Biology · doi:10.4161/rna.22269 · Cited by 622 · see citing works

Unlocking the promise of mRNA therapeutics

Rohner, E., Yang, R., Foo, K. S., Goedel, A., & Chien, K. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01491-z · Cited by 612 · see citing works

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

Ban, H., Nishishita, N., Fusaki, N., Tabata, T., Saeki, K., Shikamura, M., Takada, N., Inoue, M., Hasegawa, M., Kawamata, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103509108 · Cited by 604 · see citing works

Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells

Ohi, Y., Qin, H., Hong, C., Blouin, L., Polo, J., Guo, T.-X., Qi, Z.-X., Downey, S. L., Manos, P. D., Rossi, D. J., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2239 · Cited by 604 · see citing works

Direct reprogramming of mouse fibroblasts to neural progenitors

Kim, J., Efe, J. A., Zhu, S., Talantova, M. V., Xu, Y., Wang, S., Lipton, S. A., Zhang, K., & Ding, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103113108 · Cited by 568 · see citing works

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

Huang, S. X. L., Islam, M. N., O’Neill, J. D., Hu, Z., Yang, Y., Chen, Y., Mumau, M. D., Green, M. D., Vunjak‐Novakovic, G., Bhattacharya, J., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2754 · Cited by 565 · see citing works

The tangled history of mRNA vaccines

Dolgin, E. (2021) · Nature · doi:10.1038/d41586-021-02483-w · Cited by 556 · see citing works

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108077108 · Cited by 546 · see citing works

Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications

Liu, G., David, B. T., Trawczynski, M., & Fessler, R. G. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09935-x · Cited by 527 · see citing works

Deterministic direct reprogramming of somatic cells to pluripotency

Rais, Y., Zviran, A., Geula, S., Gafni, O., Chomsky, E., Viukov, S., Mansour, A. A., Caspi, I., Krupalnik, V., Zerbib, M., et al. (2013) · Nature · doi:10.1038/nature12587 · Cited by 522 · see citing works

Self-assembled mRNA vaccines

Kim, J., Eygeris, Y., Gupta, M., & Sahay, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.014 · Cited by 514 · see citing works

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

Han, D., Tàpia, N., Hermann, A., Hemmer, K., Höing, S., Araúzo-Bravo, M. J., Zaehres, H., Wu, G., Frank, S., Moritz, S., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.021 · Cited by 514 · see citing works

Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals

Thess, A., Grund, S., Mui, B. L., Hope, M. J., Baumhof, P., Fotin-Mleczek, M., & Schlake, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.103 · Cited by 513 · see citing works

A comparison of non-integrating reprogramming methods

Schlaeger, T. M., Daheron, L. M., Brickler, T., Entwisle, S. W., Chan, K., Cianci, A. L., DeVine, A. L., Ettenger, A., Fitzgerald, K. N., Godfrey, M., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3070 · Cited by 512 · see citing works

Methods for making induced pluripotent stem cells: reprogramming à la carte

Gonzãlez, F., Boué, S., & Belmonte, J. C. I. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2937 · Cited by 504 · see citing works

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

Ding, Q., Lee, Y., Schaefer, E. A. K., Peters, D., Veres, A., Kim, K. J., Kuperwasser, N., Motola, D., Meissner, T. B., Hendriks, W. T. J., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.11.011 · Cited by 501 · see citing works

Induced Pluripotent Stem Cells Meet Genome Editing

Hockemeyer, D., & Jaenisch, R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.013 · Cited by 499 · see citing works

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

Thier, M. C., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M. M., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.03.003 · Cited by 485 · see citing works

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

Chou, B.-K., Mali, P., Huang, X., Ye, Z., Dowey, S. N., Resar, L. M. S., Zou, C., Zhang, Y. A., Tong, J., & Cheng, L. (2011) · Cell Research · doi:10.1038/cr.2011.12 · Cited by 482 · see citing works

Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice

Darabi, R., Arpke, R. W., Irion, S., Dimos, J. T., Grskovic, M., Kyba, M., & Perlingeiro, R. C. R. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.015 · Cited by 481 · see citing works

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.022 · Cited by 475 · see citing works

Induced pluripotent stem cells — opportunities for disease modelling and drug discovery

Grs̆ković, M., Javaherian, A., Strulovici, B., & Daley, G. Q. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3577 · Cited by 474 · see citing works

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

Nance, K. D., & Meier, J. L. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00197 · Cited by 466 · see citing works

Pluripotent stem cells in regenerative medicine: challenges and recent progress

Tabar, V. S., & Studer, L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3563 · Cited by 458 · see citing works

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452 · see citing works

Induced pluripotent stem cells: the new patient?

Bellin, M., Marchetto, M. C., Gage, F. H., & Mummery, C. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3448 · Cited by 432 · see citing works

Generation of induced pluripotent stem cells from urine

Zhou, T., Benda, C., Duzinger, S., Huang, Y., Li, X., Li, Y., Guo, X., Cao, G., Chen, S., Hao, L., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011010106 · Cited by 421 · see citing works

Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery

Singh, V. K., Kalsan, M., Kumar, N., Saini, A., & Chandra, R. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00002 · Cited by 421 · see citing works

A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability

Burridge, P. W., Thompson, S. A., Millrod, M. A., Weinberg, S. H., Yuan, X., Peters, A., Mahairaki, V., Koliatsos, V. E., Tung, L., & Zambidis, E. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018293 · Cited by 420 · see citing works

The challenge and prospect of mRNA therapeutics landscape

Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107534 · Cited by 417 · see citing works

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Okano, H., Nakamura, M., Yoshida, K., Okada, Y., Tsuji, O., Nori, S., Ikeda, E., Yamanaka, S., & Miura, K. (2013) · Circulation Research · doi:10.1161/circresaha.111.256149 · Cited by 413 · see citing works

Synthetic Biology Moving into the Clinic

Ruder, W. C., Lu, T., & Collins, J. J. (2011) · Science · doi:10.1126/science.1206843 · Cited by 410 · see citing works

mir-17–92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts

Chen, J., Huang, Z., Seok, H., Ding, J., Kataoka, M., Zhang, Z., Hu, X., Wang, G., Lin, Z., Wang, S., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300658 · Cited by 398 · see citing works

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

Liang, F., Lindgren, G., Lin, A., Thompson, E. A., Ols, S., Röhss, J., John, S., Hassett, K., Yuzhakov, O., Bahl, K., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.006 · Cited by 395 · see citing works

New Modalities for Challenging Targets in Drug Discovery

Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., Grossmann, T. N., & Plowright, A. T. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201611914 · Cited by 382 · see citing works

Synthetic Biology and Personalized Medicine

Jain, K. (2012) · Medical Principles and Practice · doi:10.1159/000341794 · Cited by 380 · see citing works

Stem cells in dentistry – Part I: Stem cell sources

Egusa, H., Sonoyama, W., Nishimura, M., Atsuta, I., & Akiyama, K. (2012) · Journal of Prosthodontic Research · doi:10.1016/j.jpor.2012.06.001 · Cited by 374 · see citing works

Development of Defective and Persistent Sendai Virus Vector

Nishimura, K., Sano, M., Ohtaka, M., Furuta, B., Umemura, Y., Nakajima, Y., Ikehara, Y., Kobayashi, T., Segawa, H., Takayasu, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183780 · Cited by 368 · see citing works

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

Karagiannis, P., Takahashi, K., Saito, M. K., Yoshida, Y., Okita, K., Watanabe, A., Inoue, H., Yamashita, J. K., Todani, M., Nakagawa, M., et al. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2017 · Cited by 367 · see citing works

Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

Orlandini von Niessen, A. G., Poleganov, M. A., Rechner, C., Plaschke, A., Kranz, L. M., Fesser, S., Diken, M., Löwer, M., Vallazza, B., Beissert, T., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.011 · Cited by 365 · see citing works

A Review of the Methods for Human iPSC Derivation

Malik, N., & Rao, M. S. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-348-0_3 · Cited by 355 · see citing works

Bioengineering human myocardium on native extracellular matrix

Guyette, J. P., Charest, J. M., Mills, R. W., Jank, B. J., Moser, P. T., Gilpin, S. E., Gershlak, J. R., Okamoto, T., Gonzalez, G., Milan, D. J., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.306874 · Cited by 343 · see citing works

Realistic control of network dynamics

Cornelius, S. P., Kath, W. L., & Motter, A. E. (2013) · Nature Communications · doi:10.1038/ncomms2939 · Cited by 340 · see citing works

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

Islam, M. A., Xu, Y., Tao, W., Ubellacker, J. M., Lim, M., Aum, D., Lee, G. Y., Zhou, K., Zope, H., Yu, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0284-0 · Cited by 339 · see citing works

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

Mou, H., Zhao, R., Sherwood, R. I., Ahfeldt, T., Lapey, A., Wain, J. R., Sicilian, L., Izvolsky, K. I., Lau, F. H., Musunuru, K., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.018 · Cited by 316 · see citing works

Efficient generation of human iPSCs by a synthetic self-replicative RNA

Yoshioka, N., Gros, E., Li, H.-R., Kumar, S., Deacon, D. C., Maron, C., Muotri, A. R., Chi, N. C., Fu, X.-D., Yu, B. D., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.001 · Cited by 312 · see citing works

Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

Hajj, K. A., Ball, R. L., Deluty, S. B., Singh, S. R., Strelkova, D., Knapp, C. M., & Whitehead, K. A. (2019) · Small · doi:10.1002/smll.201805097 · Cited by 312 · see citing works

In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases

Sebastiano, V., Maeder, M. L., Angstman, J. F., Haddad, B., Khayter, C., Yeo, D. T., Goodwin, M. J., Hawkins, J. S., Ramirez, C. L., Batista, L. F. Z., et al. (2011) · Stem Cells · doi:10.1002/stem.718 · Cited by 307 · see citing works

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Gaj, T., Guo, J., Kato, Y., Sirk, S. J., & Barbas, C. F. (2012) · Nature Methods · doi:10.1038/nmeth.2030 · Cited by 306 · see citing works

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

Douvaras, P., Wang, J., Zimmer, M., Hanchuk, S., O’Bara, M. A., Sadiq, S., Sim, F. J., Goldman, J., & Fossati, V. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.06.012 · Cited by 302 · see citing works

A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

Sun, K., Li, Y., & Jin, J. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00455-6 · Cited by 301 · see citing works

5-Methylcytosine RNA Methylation in Arabidopsis Thaliana

Cui, X., Liang, Z., Shen, L., Zhang, Q., Bao, S., Geng, Y., Zhang, B., Leo, V. I., Vardy, L. A., Lu, T., et al. (2017) · Molecular Plant · doi:10.1016/j.molp.2017.09.013 · Cited by 296 · see citing works

Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.014 · Cited by 293 · see citing works

Progress in understanding reprogramming to the induced pluripotent state

Plath, K., & Lowry, W. (2011) · Nature reviews genetics · doi:10.1038/nrg2955 · Cited by 306 · see citing works

Turning straw into gold: directing cell fate for regenerative medicine

Cohen, D. E., & Melton, D. (2011) · Nature reviews genetics · doi:10.1038/nrg2938 · Cited by 283 · see citing works

Translation of Human-Induced Pluripotent Stem Cells

Sayed, N., Liu, C., & Wu, J. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.083 · Cited by 284 · see citing works

Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications

Yoshihara, M., Hayashizaki, Y., & Murakawa, Y. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9680-6 · Cited by 283 · see citing works

Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells

Itoh, M., Kiuru, M., Cairo, M. S., & Christiano, A. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100332108 · Cited by 282 · see citing works

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Svitkin, Y. V., Cheng, Y. M., Chakraborty, T., Presnyak, V., John, M., & Sonenberg, N. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx135 · Cited by 278 · see citing works

In Brief

(2010) · Nature Reviews Genetics · doi:10.1038/nrg2894

Application of Modified mRNA in Somatic Reprogramming to Pluripotency and Directed Conversion of Cell Fate

Wang, A. Y. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158148 · Cited by 33 · see citing works

Generation of Human iPSCs by Reprogramming with the Unmodified Synthetic mRNA

Annand, R. R. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1084-8_11 · Cited by 3 · see citing works

Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA

Steinle, H., Weber, M., Behring, A., Mau-Holzmann, U. A., Schlensak, C., Wendel, H. P., & Avci‐Adali, M. (2019) · Stem Cells International · doi:10.1155/2019/7641767 · Cited by 38 · see citing works

Reprogramming to Pluripotency and Differentiation of Cells with Synthetic mRNA

Wang, P., & Na, J. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_14 · Cited by 7 · see citing works