The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
Open accessAbstract
PTEN is among the most frequently inactivated tumour suppressor genes in sporadic cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor activity is dependent on its lipid phosphatase activity, which negatively regulates the PI3K–AKT–mTOR pathway. Germline mutations in PTEN have been described in a variety of rare syndromes that are collectively known as the PTEN hamartoma tumour syndromes (PHTS). Cowden syndrome is the best-described syndrome within PHTS, with approximately 80% of patients having germline PTEN mutations. Patients with Cowden syndrome have an increased incidence of cancers of the breast, thyroid and endometrium, which correspond to sporadic tumour types that commonly exhibit somatic PTEN inactivation. Pten deletion in mice leads to Cowden syndrome-like phenotypes, and tissue-specific Pten deletion has provided clues to the role of PTEN mutation and loss in specific tumour types. Studying PTEN in the continuum of rare syndromes, common cancers and mouse models provides insight into the role of PTEN in tumorigenesis and will inform targeted drug development.
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Cites
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Cited by
Haugen, B. R., Alexander, E. K., Bible, K. C., Doherty, G. M., Mandel, S. J., Nikiforov, Y. E., Pacini, F., Randolph, G. W., Sawka, A. M., Schlumberger, M., et al. (2016) · Thyroid® · doi:10.1089/thy.2015.0020 · Cited by 16,535
The functions and regulation of the PTEN tumour suppressor
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
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PI3K/AKT signaling pathway and cancer: An updated review
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Metadata
- Authors
- Hollander, M. C., Blumenthal, G. M., & Dennis, P. A.
- Venue
- Nature Reviews Cancer
- Published
- 2011-03-24
- Volume
- 11
- Issue
- 4
- Pages
- 289-301
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1996222881
- Cited by
- 794
- References
- 20
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
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