Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
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Primary mouse astrocytes secrete exosomes containing miRNAs.
“Astrocytes secrete numerous miRNAs via exosomes”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [11]
Astrocytes secrete exosomes containing miR-19a, which regulates PTEN expression in brain tumor cells, thus influencing the outgrowth of brain metastases.
“Recently it has been demonstrated that astrocytes secrete exosomes containing miR-19a, which regulates PTEN expression in brain tumor cell, thus influencing the outgrowth of brain metastases [11].”
From Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes (2017) · cites this paper as [11]
Under pathological conditions, exosomes increase propagation of neurotoxic proteins in neurodegenerative diseases and aggravate brain tumor metastasis and progression.
“Under pathological conditions, exosomes have been found to increase the propagation of neurotoxic proteins in neurodegenerative diseases51,52,53, and aggravate brain tumor metastasis and progression14.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [14]
Diverse types of cells including neurons can secrete exosomes, which transfer functional proteins, mRNAs and/or microRNAs to recipient cells.
“Diverse types of cells including neurons can secrete exosomes, which transfer functional proteins11,12, mRNAs and/or microRNAs (miRNAs)13,14 to recipient cells.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [14]
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- Authors
- Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., Wang, H., Ellis, K., Cheerathodi, M., McCarty, J. H., Palmieri, D., Saunus, J., Lakhani, S., Huang, S., Sahin, A. A., Aldape, K. D., Steeg, P. S., & Yu, D.
- Venue
- Nature
- Published
- 2015-10-19
- Volume
- 527
- Issue
- 7576
- Pages
- 100-104
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC4819404
- Cited by
- 1,080
- References
- 24
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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