Cited by 1,080

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, Lin, Zhang, Siyuan, Yao, Jun, Lowery, Frank J., Zhang, Qingling, Huang, Wen-Chien, Li, Ping, Li, Min +14 more·2015·Nature

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  1. [1]Quail DF Joyce JA Microenvironmental regulation of tumor progression and metastasis. Nat. Med 2013 19 1423 1437 24202395 PMC3954707
  2. [2]Park ES Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis. Proc. Natl. Acad. Sci 2011 108 17456 17461 21987811 PMC3198333
  3. [3]Joyce JA Pollard JW Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009 9 239 252 19279573 PMC3251309
  4. [4]Vanharanta S Massagué J Origins of Metastatic Traits. Cancer Cell 2013 24 410 421 24135279 PMC3998120
  5. [5]Gray J Cancer: Genomics of metastasis. Nature 2010 464 989 990 20393550
  6. [6]Friedl P Alexander S Cancer Invasion and the Microenvironment: Plasticity and Reciprocity. Cell 2011 147 992 1009 22118458
  7. [7]Zhang S Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat. Med 2011 17 461 469 21399647 PMC3877934
  8. [8]Gonzalez-Angulo AM PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol. Cancer Ther 2011 10 1093 1101 21490305 PMC3112276
  9. [9]Wikman H Relevance of PTEN loss in brain metastasis formation of breast cancer patients. Breast Cancer Res 2012 14 R49 22429330 PMC3446383
  10. [11]Hopkins BD A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival. Science 2013 341 399 402 23744781 PMC3935617
  11. [12]Miething C PTEN action in leukaemia dictated by the tissue microenvironment. Nature 2014 510 402 406 24805236 PMC4165899
  12. [13]Mecha M An easy and fast way to obtain a high number of glial cells from rat cerebral tissue: A beginners approach 2011 < http://dx.doi.org/10.1038/protex.2011.218> · DOI
  13. [14]Zhu H Han C Lu D Wu T miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. Am. J. Pathol 2014 184 2828 2839 25239565 PMC4188863
  14. [15]Liu S-Q Jiang S Li C Zhang B Li Q-J miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. J. Biol. Chem 2014 289 12446 12456 24644282 PMC4007439
  15. [16]Olive V miR-19 is a key oncogenic component of mir-17-92. Genes Dev 2009 23 2839 2849 20008935 PMC2800084
  16. [17]Olive V Jiang I He L mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int. J. Biochem. Cell Biol 2010 42 1348 1354 20227518 PMC3681296
  17. [18]Ventura A Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008 132 875 886 18329372 PMC2323338
  18. [19]Mittelbrunn M Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun 2011 2 282 21505438 PMC3104548
  19. [20]Suetsugu A Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv. Drug Deliv. Rev 2013 65 383 390 22921594
  20. [22]Kesimer M Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J 2009 23 1858 1868 19190083 PMC2698655
  21. [23]Peinado H Melanoma exosomes educate bone marrow progenitor cells toward a prometastatic phenotype through MET. Nat. Med 2012 18 883 891 22635005 PMC3645291
  22. [24]Conti I Rollins BJ CCL2 (monocyte chemoattractant protein-1) and cancer. Semin. Cancer Biol 2004 14 149 154 15246049
  23. [25]Qian B-Z CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011 475 222 225 21654748 PMC3208506
  24. [26]Bonapace L Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature 2014 515 130 133 25337873
  25. [27]Lu J 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 2009 16 195 207 19732720 PMC2754239
  26. [29]Zhang S Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases. Cancer Res 2013 73 5764 5774 23913825 PMC3781592
  27. [30]Gril B Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain. J. Natl. Cancer Inst 2008 100 1092 1103 18664652 PMC2575427

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Authors
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., Wang, H., Ellis, K., Cheerathodi, M., McCarty, J. H., Palmieri, D., Saunus, J., Lakhani, S., Huang, S., Sahin, A. A., Aldape, K. D., Steeg, P. S., & Yu, D.
Venue
Nature
Published
2015-10-19
Volume
527
Issue
7576
Pages
100-104
ISSN
  • 0028-0836
  • 1476-4687
Cited by
1,080
References
24
Language
en

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